Anti-Human CD3 Recombinant Antibody (Muromonab-CD3) (CAT#: TAB-019)
Recombinant monoclonal antibody to Human CD3. Muromonab-CD3 (trade name Orthoclone OKT3,) is an immunosuppressant drug given to reduce acute rejection in patients with organ transplants. It is a monoclonal antibody targeted at the CD3 receptor, a membrane protein on the surface of T cells. It was the first monoclonal antibody to be approved for clinical use in humans.
Specific Inquiry
DB
Figure 1 Anti-Human CD3 Therapeutic Antibody (TAB-019) in DB
Dot Blot analysis of TAB-019 was performed by coating with human CD3 protein (His tag).
TAB-019 incubation concentration: 2 μg/mL.
HRP-conjugated goat anti-mouse IgG was used as a secondary antibody (1: 2000)
WB
Figure 2 Anti-Human CD3 Therapeutic Antibody (TAB-019) in WB
Western blot analysis of TAB-019 was performed with human CD3 protein onto a 12% Tris-HCl polyacrylamide gel. Proteins were transferred to a CN membrane and blocked with 5% skim milk for at least one hour. Membranes were probed with TAB-019 and HRP goat anti-mouse IgG was used as a secondary antibody (1: 2000). Chemiluminescent detection was performed.
Lane 1: Reduced antigen (0.5 μg)
Lane 2: Reduced antigen (1.0 μg)
Lane 3: Reduced antigen (1.5 μg)
Specifications
- Immunogen
- The details of the immunogen for this antibody are not available.
- Host Species
- Mouse
- Derivation
- Mouse
- Type
- IgG2a - kappa
- Specificity
- Tested positive against native human antigen
- Species Reactivity
- Human
- Applications
- Suitable for use in FC, IP, ELISA, Neut, FuncS, IF, WB and most other immunological methods.
- Trade name
- orthoclone okt3
- CAS
- 140608-64-6
- Generic Name
- muromonab-CD3
- ATC Code
- L04AA02
- DrugBank
- DB00075
- UNII
- JGA39ICE2V
- ChEMBL
- CHEMBL1201608
- MW
- 146.091 kDa
- Related Disease
- Acute kidney transplant rejection, Acute kidney transplant rejection (reversal)
Product Property
- Purity
- >95.0% as determined by Analysis by RP-HPLC & analysis by SDS-PAGE.
- Storage
- Store at 4°C for up to 3 months. For longer term storage aliquot into small volumes and store at -20°C.
Target
- Alternative Names
- muromonab-CD3;orthoclone okt3;140608-64-6;Orthoclone OKT3;DB00075 CD3E;CD3e molecule, epsilon (CD3-TCR complex);CD3e antigen, epsilon polypeptide (TiT3 complex);T-cell surface glycoprotein CD3 epsilon chain;CD3-epsilon;T-cell surface antigen T3/Leu-4 epsi
- Gene ID
- 916
- UniProt ID
- P07766
Related Resources
Please refer to Muromonab-CD3 Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Muromonab-CD3.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "Muromonab-Cd3"
Afuco™ Anti-CD3E ADCC Recombinant Antibody (Muromonab-Cd3), ADCC EnhancedThis product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to Human CD3. Muromonab-CD3 (trade name Orthoclone OKT3,) is an immunosuppressant drug given to reduce acute rejection in patients with organ transplants. It is a monoclonal antibody targeted at the CD3 receptor, a membrane protein on the surface of T cells. It was the first monoclonal antibody to be approved for clinical use in humans.
See other products for "CD3E"
Rat Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-H28 | Anti-Human CD3E Recombinant Antibody (Ertumaxomab) | ELISA, FC, IP, FuncS, IF, Neut, ICC | IgG2a / G2b |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| DrMAB-988 | Mouse Anti-CD3E Recombinant Antibody (clone UCHT1) | FC, IHC, WB, FuncS, IF | Mouse IgG1 F(ab')2 |
| DrMAB-989 | Mouse Anti-CD3E Recombinant Antibody (clone UCHT1); Fab Fragment | FC, Cyt, Stim, PP, Agonist | Mouse Fab |
| PFBL-643 | Mouse Anti-CD3E Recombinant Antibody (clone 2C11); Fab Fragment | WB, IHC, IF, FuncS | Mouse Fab |
| FAMAB-0049-YC-F(E) | Hamster Anti-CD3E Recombinant Antibody (clone 145-2C11); Fab Fragment | FC, FuncS | Hamster Fab |
| HPAB-0347-YJ-F(E) | Rat Anti-CD3E Recombinant Antibody (clone 1Ab); Fab Fragment | FC, WB, Inhib | Rat Fab |
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-714 | Anti-CD3E Recombinant Antibody (Visilizumab) | FuncS, IF, Neut, ELISA, FC, IP, ICC | IgG2 |
| TAB-H52 | Anti-Human CD3E Recombinant Antibody (Otelixizumab) | FC, IP, ELISA, Neut, FuncS, IF, WB | IgG1 - lambda |
| TAB-420CQ | Anti-Human CD3E Recombinant Antibody (Visilizumab) | ELISA, IHC, FC, IP, IF, FuncS | IgG2, κ |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-245 | Anti-Human CD3 epsilon Recombinant Antibody (Foralumab) | WB, ELISA, FC, IP, FuncS, IF, Neut | IgG1 - kappa |
| TAB-124CL | Human Anti-CD3E Recombinant Antibody (TAB-124CL) | ELISA | Human IgG |
Immunotoxin
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AGTO-G010E | Anti-CD3E immunotoxin UCHT1 (scFv)-PE | Cytotoxicity assay, Function study | |
| AGTO-G010D | Anti-CD3E immunotoxin UCHT1 (scFv)-DT | Cytotoxicity assay, Function study | |
| AGTO-G010R | Anti-CD3E immunotoxin UCHT1 (scFv)-RTA | Cytotoxicity assay, Function study | |
| AGTO-L049E | anti-CD3E immunotoxin UCHT1 (IgG)-PE | Cytotoxicity assay, Functional assay | |
| AGTO-L049D | anti-CD3E immunotoxin UCHT1 (IgG)-DT | Cytotoxicity assay, Functional assay |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-600NL | Recombinant Anti-mouse CD3e Antibody. | IP, IHC-Fr, FuncS, ICC, FACS | |
| FAMAB-0047CQ | Mouse Anti-CD3E Recombinant Antibody (clone CLB-T3/4.1) | ELISA, IF, IP | Mouse IgG1 |
| FN-264CQ | Rat Anti-CD3E Recombinant Antibody (clone KT3) | FC, IHC | Rat IgG2a |
| HPAB-0347-YJ | Rat Anti-CD3E Recombinant Antibody (clone 1Ab) | FC, WB, Inhib, FuncS | Rat IgG |
| HPAB-A1283-YJ | Hamster Anti-CD3E Recombinant Antibody (clone 145.2c11) | ELISA, WB, IP, FC, FuncS, Inhib | Hamster IgG |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBL-643 | Mouse Anti-CD3E Recombinant Antibody (clone 2C11); scFv Fragment | WB, IHC, IF, FuncS | Mouse scFv |
| FAMAB-0049-YC-S(P) | Hamster Anti-CD3E Recombinant Antibody (clone 145-2C11); scFv Fragment | FC, FuncS | Hamster scFv |
| FAMAB-0052-YC-S(P) | Hamster Anti-CD3E Recombinant Antibody (clone 500A2); scFv Fragment | ELISA | Hamster scFv |
| FAMAB-0047CQ-S(P) | Mouse Anti-CD3E Recombinant Antibody (clone CLB-T3/4.1); scFv Fragment | ELISA, IF, IP | Mouse scFv |
| HPAB-0263-YJ-S(P) | Rabbit Anti-CD3E Recombinant Antibody (clone 645); scFv Fragment | ELISA, FC, FuncS | Rabbit scFv |
Chimeric Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABX-032 | Recombinant Grey hamster Anti-CD3E Antibody (2C11) | WB, ELISA, FuncS, IP | IgG |
| PABX-033 | Recombinant Grey hamster Anti-CD3E Antibody (17A2) | WB, ELISA, FuncS | IgG |
| PABX-032-F (E) | Recombinant Grey hamster Anti-CD3E Antibody Fab Fragment (2C11) | WB, ELISA, FuncS | Fab |
| PABX-033-F (E) | Recombinant Grey hamster Anti-CD3E Antibody Fab Fragment (17A2) | WB, ELISA, FuncS | Fab |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABX-032-S (P) | Recombinant Grey hamster Anti-CD3E Antibody scFv Fragment (2C11) | WB, ELISA, FuncS | scFv |
| PABX-033-S (P) | Recombinant Grey hamster Anti-CD3E Antibody scFv Fragment (17A2) | WB, ELISA, FuncS | scFv |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0558 | Hi-Affi™ Rabbit Anti-CD3E Recombinant Antibody (clone DS558AB) | IHC-P | Rabbit IgG |
| MOR-0058-FY | Rabbit Anti-CD3E Recombinant Antibody (clone AFY0029) | FC, ICC, IF, IHC-P, WB | Rabbit IgG |
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-245 | Afuco™ Anti-CD3E ADCC Recombinant Antibody (Foralumab), ADCC Enhanced | ELISA, FC, IP, FuncS, IF | ADCC enhanced antibody |
| AFC-TAB-H52 | Afuco™ Anti-CD3E ADCC Recombinant Antibody (Otelixizumab), ADCC Enhanced | FC, IP, ELISA, Neut, FuncS, IF | ADCC enhanced antibody |
| AFC-TAB-714 | Afuco™ Anti-CD3E ADCC Recombinant Antibody (Visilizumab), ADCC Enhanced | FuncS, IF, Neut, ELISA, FC, IP | ADCC enhanced antibody |
| AFC-TAB-019 | Afuco™ Anti-CD3E ADCC Recombinant Antibody (Muromonab-Cd3), ADCC Enhanced | FC, IP, ELISA, Neut, FuncS, IF | ADCC enhanced antibody |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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