Anti-Human DLL4 Recombinant Antibody (Demcizumab) (CAT#: TAB-204)
Recombinant monoclonal antibody to DLL4. Demcizumab is a humanized monoclonal antibody designed for the treatment of cancer.
Specific Inquiry
Normal Tissue
RNA Expression
Figure 1 IHC staining of human small intestine
(Immunohistochemical staining of human small intestine shows strong membranous positivity in glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/23392/51479_A_4_2_selected.jpg
(Immunohistochemical staining of human small intestine shows strong membranous positivity in glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/23392/51479_A_4_2_selected.jpg
Figure 2 Colon
(Endothelial cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/23392/51479_A_9_3.jpg
(Endothelial cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/23392/51479_A_9_3.jpg
Figure 3 Liver
(Cholangiocytes Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Hepatocytes Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/23392/51479_A_8_4.jpg
(Cholangiocytes Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Hepatocytes Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/23392/51479_A_8_4.jpg
Figure 4 Kidney
(Cells in tubules Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/23392/51479_A_8_5.jpg
(Cells in tubules Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/23392/51479_A_8_5.jpg
Figure 5 Testis
(Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/23392/51479_A_4_6.jpg
(Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/23392/51479_A_4_6.jpg
Figure 6 RNA cell line category: Group enriched (BJ hTERT+, HUVEC TERT2, SCLC-21H)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000128917-DLL4
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000128917-DLL4
Specifications
- Immunogen
- Partial recombinant DLL4 ragment.
- Host Species
- Mouse
- Derivation
- Humanized (from mouse)
- Type
- IgG2 - kappa
- Specificity
- Tested positive against native human antigen.
- Species Reactivity
- Human
- Applications
- Suitable for use in ELISA, FC, IP, FuncS, IF, Neut, WB and most other immunological methods.
- CAS
- 1243262-17-0
- Generic Name
- Demcizumab
- MW
- 145.3 kDa
- Related Disease
- Cancers
Product Property
- Purity
- >97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
- Storage
- Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing of samples.
Target
- Alternative Names
- Demcizumab;1243262-17-0;OMP-21M18;DLL4;delta-like 4 (Drosophila);delta like 4 homolog (Drosophila);delta-like protein 4;delta4;delta 4;delta ligand 4;notch ligand DLL4;delta-like 4 homolog;delta-like 4 protein;notch ligand delta-2;drosophila Delta homolog
- Gene ID
- 54567
- UniProt ID
- Q9NR61
Related Resources
Please refer to Demcizumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Demcizumab.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "Demcizumab"
Afuco™ Anti-DLL4 ADCC Recombinant Antibody (Demcizumab), ADCC EnhancedThis product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to DLL4. Demcizumab is a humanized monoclonal antibody designed for the treatment of cancer.
See other products for "DLL4"
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-744 | Anti-DLL4 Recombinant Antibody | WB, Neut, ELISA, IF, IP, FuncS, FC | IgG1 - kappa |
| TAB-218MZ | Human Anti-DLL4 Recombinant Antibody (TAB-218MZ) | ELISA, FC, Neut | Human IgG |
| TAB-219MZ | Human Anti-DLL4 Recombinant Antibody (TAB-219MZ) | ELISA, FC, Neut, WB | Human IgG |
| TAB-220MZ | Human Anti-DLL4 Recombinant Antibody (TAB-220MZ) | ELISA, FC, Neut | Human IgG |
| TAB-221MZ | Human Anti-DLL4 Recombinant Antibody (TAB-221MZ) | ELISA, FC, Neut | Human IgG |
Rat Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-217CL | Human Anti-DLL4 Recombinant Antibody (TAB-217CL) | WB, IHC, IF, FC, Inhib | Human IgG |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-216MZ | Mouse Anti-DLL4 Recombinant Antibody (TAB-216MZ) | FC, FuncS | Mouse IgG |
| TAB-216MZ-S(P) | Mouse Anti-DLL4 Recombinant Antibody; scFv Fragment (TAB-216MZ-S(P)) | FC | Mouse scFv |
| TAB-227MZ-F(E) | Anti-Human DLL4 Recombinant Antibody Fab Fragment (1C1) | ELISA, FC | |
| TAB-232MZ-F(E) | Rat Anti-DLL4 Recombinant Antibody; Fab Fragment (TAB-232MZ-F(E)) | ELISA, FC | Rat Fab |
| TAB-233MZ-F(E) | Rat Anti-DLL4 Recombinant Antibody; Fab Fragment (TAB-233MZ-F(E)) | ELISA, FC | Rat Fab |
Chimeric Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-217MZ | Human Anti-DLL4 Recombinant Antibody (TAB-217MZ) | FC, FuncS | Chimeric (mouse/human) IgG |
| TAB-217MZ-S(P) | Mouse Anti-DLL4 Recombinant Antibody; scFv Fragment (TAB-217MZ-S(P)) | FC | Mouse scFv |
| TAB-217MZ-F(E) | Human Anti-DLL4 Recombinant Antibody; Fab Fragment (TAB-217MZ-F(E)) | FC | Chimeric antibody (mouse/human) |
Blocking Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-707CQ | Hamster Anti-Dll4 Recombinant Antibody (clone HMD4-2) | Block | Hamster IgG |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-4140 | Hi-Affi™ Rabbit Anti-DLL4 Recombinant Antibody (clone SI213DS) | ELISA | Rabbit IgG |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0207-CN | Human Anti-DLL4 Recombinant Antibody (HPAB-0207-CN) | ELISA, WB, FC, IHC, IF, ICC | Chimeric (mouse/human) IgG1, κ |
| MRO-1817-CN | Rabbit Anti-DLL4 Polyclonal Antibody (MRO-1817-CN) | WB, IF, IHC, FC | Rabbit IgG |
| MRO-1818-CN | Rabbit Anti-DLL4 Polyclonal Antibody (MRO-1818-CN) | WB, IF, IHC, FC | Rabbit IgG |
| FN-220CQ | Hamster Anti-Dll4 Recombinant Antibody (clone HMD4-1) | FC, FuncS, IF | Hamster IgG |
| HPAB-0211-WJ | Mouse Anti-DLL4 Recombinant Antibody (clone MMGZ01) | ELISA | Mouse IgG |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0075-CN-S(P) | Human Anti-DLL4 Recombinant Antibody; scFv Fragment (HPAB-0075-CN-S(P)) | ELISA, WB, FC | Human scFv |
| HPAB-0076-CN-S(P) | Human Anti-DLL4 Recombinant Antibody; scFv Fragment (HPAB-0076-CN-S(P)) | ELISA, WB, FC | Human scFv |
| HPAB-0142-FY-S(P) | Human Anti-DLL4 Recombinant Antibody (clone 12.3 1 C1); scFv Fragment | ELISA | Human scFv |
| HPAB-0156CQ-S(P) | Human Anti-DLL4 Recombinant Antibody (clone YW26.82); scFv Fragment | ELISA, FC, IHC, Block | Human scFv |
| HPAB-0211-WJ-S(P) | Mouse Anti-DLL4 Recombinant Antibody (clone MMGZ01); scFv Fragment | ELISA | Mouse scFv |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0203-CN-F(E) | Human Anti-DLL4 Recombinant Antibody; Fab Fragment (HPAB-0203-CN-F(E)) | ELISA, WB, FC, IP | Human Fab |
| HPAB-0204-CN-F(E) | Human Anti-DLL4 Recombinant Antibody; Fab Fragment (HPAB-0204-CN-F(E)) | ELISA, WB, FC, IP | Human Fab |
| HPAB-0205-CN-F(E) | Human Anti-DLL4 Recombinant Antibody; Fab Fragment (HPAB-0205-CN-F(E)) | ELISA, WB, FC, IP | Human Fab |
| HPAB-0206-CN-F(E) | Mouse Anti-DLL4 Recombinant Antibody; Fab Fragment (HPAB-0206-CN-F(E)) | ELISA, WB, FC, IHC, IF, ICC | Mouse Fab |
| HPAB-0208-CN-F(E) | Human Anti-DLL4 Recombinant Antibody; Fab Fragment (HPAB-0208-CN-F(E)) | ELISA, WB, FC, IHC, IF, ICC | Humanized Fab |
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-204 | Afuco™ Anti-DLL4 ADCC Recombinant Antibody (Demcizumab), ADCC Enhanced | ELISA, FC, IP, FuncS, IF, Neut | ADCC enhanced antibody |
Single-domain Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1512-FY | Recombinant Llama Anti-DLL4 Single Domain Antibody (56A09) | Block, ELISA, FC | Llama VHH |
| HPAB-1513-FY | Recombinant Llama Anti-DLL4 Single Domain Antibody (56H08) | Block, ELISA, FC | Llama VHH |
| HPAB-1514-FY | Recombinant Llama Anti-DLL4 Single Domain Antibody (104G01) | Block, ELISA, FC | Llama VHH |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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