Products

Edrecolomab (TAB-701)

Recombinant mouse monoclonal antibody expressed in Sp2/0 mouse myeloma cells binding to human EpCAM/17-1A. Edrecolomab is a mouse-derived monoclonal antibody targeting the cell-surface glycoprotein EpCAM/17-1A, which is expressed on epithelial tissues and on various carcinomas. Preliminary studies had shown promise of a possible use in patients with stage III colorectal carcinoma. However, when put to a phase III study it did not provide any benefit when compared to conventional chemotherapeutic agents. Edrecolomab was well tolerated in these studies and as such research has now concentrated on whether it can be of any use in other forms of cancer.      

Specifications
Immunogen
The details of the immunogen for this antibody are not available.
Host
Mouse
Derivation
Mouse
Type
IgG2a - kappa
Species Reactivity
Human
Applications
Suitable for use in ELISA, IP, FC, FuncS, IF, Neut and most other immunological methods.
Trade name
panorex
CAS NO.
156586-89-9
Generic Name
Edrecolomab
ATC Code
L01XC01
Related Disease
Colon cancers
Target
Alternative Names
Edrecolomab; panorex; 156586-89-9; 17-1A; MAb17-1A; Panorex; EPCAM; epithelial cell adhesion molecule
Entrez Gene ID
4072
UniProt ID
P16422

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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