Anti-Human IFNG Recombinant Antibody (Fontolizumab) (CAT#: TAB-041)
Recombinant monoclonal antibody to IFNG. Fontolizumab (planned trade name HuZAF) is a humanized monoclonal antibody and an immunosuppressive drug for the treatment of auto-immune diseases like Crohn's disease.
Specific Inquiry
Activ
Figure 1 Mean (SEM) Crohn’s disease activity index (CDAI) for patients receiving two doses of study drug.
Comparison is change from baseline value for each fontolizumab group versus placebo group.
Hommes, D. W., Mikhajlova, T. L., Stoinov, S., Štimac, D., Vucelic, B., Lonovics, J.,... & Lee, S. (2006). Fontolizumab, a humanised anti-interferon γ antibody, demonstrates safety and clinical activity in patients with moderate to severe Crohn’s disease. Gut, 55(8), 1131-1137.
Specifications
- Immunogen
- The details of the immunogen for this antibody are not available.
- Host Species
- Mouse
- Derivation
- Humanized (from mouse)
- Type
- IgG1
- Specificity
- Tested positive against native human antigen.
- Species Reactivity
- Human
- Applications
- IP, IF, FuncS, FC, Neut, ELISA, IHC, Activ
- Trade name
- huzaf
- CAS
- 326859-36-3
- Generic Name
- Fontolizumab
- UNII
- 6J92H2439Z
- MW
- 150 kDa
- Related Disease
- Crohn's disease (CD)
Product Property
- Purity
- >95.0%, determined by analysis by RP-HPLC & analysis by SDS-PAGE.
- Storage
- Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing of samples.
Applications
- Application Notes
- The IFNG antibody has been reported in applications of IP, IF, FuncS, FC, Neut, ELISA, IHC, Activ.
Target
- Alternative Names
- Fontolizumab;huzaf;326859-36-3;HuZAF;flintozumab;IFNG;interferon, gamma;interferon gamma;IFN-gamma;immune interferon;IFG;IFI;
- Gene ID
- 3458
- UniProt ID
- P01579
Related Resources
Please refer to Fontolizumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Fontolizumab.
Inflammatory Bowel Diseases
Rheumatoid Arthritis
Systemic Lupus Erythematosus
Primary Immunodeficiency
Maturity Onset Diabetes of the Young
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "Fontolizumab"
Afuco™ Anti-IFNG ADCC Recombinant Antibody (Fontolizumab), ADCC EnhancedThis product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to IFNG. Fontolizumab (planned trade name HuZAF) is a humanized monoclonal antibody and an immunosuppressive drug for the treatment of auto-immune diseases like Crohn's disease.
See other products for "IFNG"
Single-domain Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NABL-090 | Recombinant Anti-human IFNG VHH Single Domain Antibody | WB, ELISA, IHC, FC, FuncS | Llama VHH |
| TAB-140CT | Anti-Human IFN-γ Therapeutic Single Domain Antibody (TAB-140CT) | ELISA | Single domain antibody |
| TAB-141CT | Anti-Human IFN-γ Therapeutic Single Domain Antibody (TAB-141CT) | ELISA | Single domain antibody |
| TAB-142CT | Anti-Human IFN-γ Therapeutic Single Domain Antibody (TAB-142CT) | ELISA | Single domain antibody |
| TAB-143CT | Anti-Human IFN-γ Therapeutic Single Domain Antibody (TAB-143CT) | ELISA | Single domain antibody |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0289MC | Recombinant Anti-Canine IFN-gamma Antibody. | WB, ELISA |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABX-112 | Recombinant Human Anti-IFN Antibody (ScFv01) | Neut, FuncS | IgG |
| PABX-112-S (P) | Recombinant Human Anti-IFN Antibody scFv Fragment (ScFv01) | Neut, FuncS | scFv |
| PABX-113-S (P) | Recombinant Human Anti-IFN-gamma Antibody scFv Fragment (HuZAF) | WB, ELISA, FuncS | scFv |
| PABX-112-F (E) | Recombinant Human Anti-IFN Antibody Fab Fragment (ScFv01) | Neut, FuncS | Fab |
| TAB-423CQ | Anti-Human IFNG Recombinant Antibody (Emapalumab) | ELISA, IHC, FC, IP, IF, FuncS | IgG1, λ1 |
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABX-113 | Recombinant Human Anti-IFN-gamma Antibody (HuZAF) | WB, ELISA, FuncS | IgG |
| PABX-113-F (E) | Recombinant Human Anti-IFN-gamma Antibody Fab Fragment (HuZAF) | WB, ELISA, FuncS | Fab |
Blocking Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1002CQ | Mouse Anti-IFNG Recombinant Antibody (clone CBL253) | Inhib, IHC, IP | Mouse IgG1 |
| NEUT-1008CQ | Mouse Anti-IFNG Recombinant Antibody (clone B133.5) | Block | Mouse IgG1 |
| NEUT-1013CQ | Mouse Anti-IFNG Recombinant Antibody (clone B-B1) | Block, FC | Mouse IgG1 |
| NEUT-1014CQ | Mouse Anti-IFNG Recombinant Antibody (clone D9D10) | Block, FC, ELISA, WB | Mouse IgG1 |
| NEUT-1033CQ | Mouse Anti-IFNG Recombinant Antibody (clone SN-6) | ELISA, Block | Mouse IgG1, κ |
Neutralizing Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1017CQ | Mouse Anti-IFNG Recombinant Antibody (clone MD-1) | ELISA, ELISPOT, Neut, WB, FC, IHC-Fr | Mouse IgG1 |
| NEUT-1018CQ | Mouse Anti-IFNG Recombinant Antibody (clone NIB42) | ELISA, Neut, IP, RIA | Mouse IgG1 |
| NEUT-1019CQ | Mouse Anti-Ifng Recombinant Antibody (clone CBL981) | ELISA, Neut, WB | Mouse IgG1 |
| NEUT-1020CQ | Rat Anti-Ifng Recombinant Antibody (clone mAb0854) | IHC-Fr, Neut | Rat IgG1 |
| NEUT-1021CQ | Rat Anti-Ifng Recombinant Antibody (clone R4-6A2) | ELISA, IHC, IHC-Fr, Neut, WB | Rat IgG1 |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1742 | Rabbit Anti-IFNG Recombinant Antibody (clone DS1742AB) | WB | Rabbit IgG |
| MOR-4228 | Rabbit Anti-IFNG Recombinant Antibody (clone SI307DS) | FC | Rabbit IgG |
| MOR-4229 | Rabbit Anti-IFNG Recombinant Antibody (clone SI308DS) | FC | Rabbit IgG |
| MOR-4230 | Rabbit Anti-IFNG Recombinant Antibody (clone SI309DS) | FC | Rabbit IgG |
| MOR-4600 | Rabbit Anti-IFNG Recombinant Antibody (clone TH113DS) | WB | Rabbit IgG |
Epitope-Specific Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| EPAF-0882LC | Mouse Anti-IFNG Recombinant Antibody (clone MIF3009) | ELISA | Mouse IgG1 |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0040-YC-F(E) | Human Anti-IFNG Recombinant Antibody; Fab Fragment (HPAB-0040-YC-F(E)) | Neut | Human Fab |
| HPAB-0041-YC-F(E) | Human Anti-IFNG Recombinant Antibody; Fab Fragment (HPAB-0041-YC-F(E)) | Neut | Human Fab |
| HPAB-0042-YC-F(E) | Human Anti-IFNG Recombinant Antibody; Fab Fragment (HPAB-0042-YC-F(E)) | ELISA, Neut | Human Fab |
| FAMAB-0176-YC-F(E) | Mouse Anti-IFNG Recombinant Antibody (clone D9DlO); Fab Fragment | ELISA, WB | Mouse Fab |
| FAMAB-0162-CN-F(E) | Human Anti-IFNG Recombinant Antibody (clone 41ms4G); Fab Fragment | ELISA | Human Fab |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-083CQ | Mouse Anti-IFNG Recombinant Antibody (clone YC117) | FC | Mouse IgG2b |
| MOB-084CQ | Mouse Anti-IFNG Recombinant Antibody (clone YC116) | ELISA, FC | Mouse IgG1 |
| MOB-085CQ | Rabbit Anti-Guinea Pig IFNG Polyclonal Antibody | ICC, IHC, WB, IP | Rabbit IgG |
| MOB-083LC | Mouse Anti-IFNG Recombinant Antibody (clone YC114) | FC, IP, WB | Mouse IgG |
| MRO-0858-CN | Rabbit Anti-IFNG Recombinant Antibody (clone JM10-10) | WB, IHC, FC | Rabbit IgG |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0176-YC-S(P) | Mouse Anti-IFNG Recombinant Antibody (clone D9DlO); scFv Fragment | ELISA, WB | Mouse scFv |
| HPAB-0640-WJ-S(P) | Human Anti-IFNG Recombinant Antibody; scFv Fragment (HPAB-0640-WJ-S(P)) | Neut | Human scFv |
| HPAB-0642-WJ-S(P) | Human Anti-IFNG Recombinant Antibody; scFv Fragment (HPAB-0642-WJ-S(P)) | Neut | Human scFv |
| HPAB-S0067-YC-S(P) | Human Anti-IFNG Recombinant Antibody (clone chAF2); scFv Fragment | ELISA, Neut | Mouse scFv |
| HPAB-S0068-YC-S(P) | Human Anti-IFNG Recombinant Antibody (clone Haf25); scFv Fragment | ELISA, Neut | Humanized scFv |
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-041 | Afuco™ Anti-IFNG ADCC Recombinant Antibody (Fontolizumab), ADCC Enhanced | IP, IF, FuncS, FC, Neut, ELISA | ADCC enhanced antibody |
| AFC-TAB-423CQ | Afuco™ Anti-IFNG ADCC Recombinant Antibody (Emapalumab), ADCC Enhanced | ELISA, IHC, FC, IP, IF, FuncS | ADCC enhanced antibody |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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