Anti-Human IL12+IL23 Recombinant Antibody (Ustekinumab) (CAT#: TAB-063)

Recombinant monoclonal antibody to IL12+IL23. Ustekinumab (INN, experimental name CNTO 1275, proprietary commercial name Stelara, Centocor) is a human monoclonal antibody. It is directed against interleukin 12 and interleukin 23, naturally occurring proteins that regulate the immune system and immune-mediated inflammatory disorders.


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  • Purity:
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  • Published Data
  • Tested Data
  • Datasheet
  • MSDS
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Figure 1 Skin group population assessments.

Figure 1 Skin group population assessments.

a) Skin Physician Global Assessment Responders at week 28. b) Change from baseline in the Sarcoidosis Activity and Severity Index (ΔSASI) score over time. c) Skin domain of the extrapulmonary Physician Organ Severity Tool (ePOST) defined as the percentage of patients with a score improvement of ≥2 points over time. d) Change from baseline in ePOST (ΔePOST) over time. #: nominal p-value versus placebo.

Judson, M. A., Baughman, R. P., Costabel, U., Drent, M., Gibson, K. F., Raghu, G., ... & Wijsenbeek, M. S. (2014). Safety and efficacy of ustekinumab or golimumab in patients with chronic sarcoidosis. European Respiratory Journal, erj00009-2014.

Figure 2 Mutational analyses of ustekinumab epitope.

Figure 2 Mutational analyses of ustekinumab epitope.

(a) Binding of human p40 and epitope variants to ustekinumab. Amino acids E45, E59, D62, M23, L40, and S43 are important IL-12/IL-23p40 residues for ustekinumab binding by ELISA. (b) Ustekinumab binding of p40 mutants (E45A, E59A, D62A, and triple combination) that disrupt antibody/antigen salt bridges by competition ELISA. Hu p40,wild-type humanp40; C177S, chimeric human/mouse p40 protein (hybrid D1-mouseD2-humanD3)with the free Cys177 mutated to Ser. The hybrid D1 domain is a mouse sequence, with all ustekinumab epitope residues substituted at the corresponding positions. (c) Ustekinumab binding of human/mouse swap mutants by competition ELISA. Hu p40 and C177S are the same as (b). P1, P2, and P3 represent human-to-mouse changes in the C177S hybrid D1 domain (G61L, 40LDQSSEVL47→40SDQRHGVI47, and M23T/Q56T, respectively). P1+P2 is a combination of P1 and P2 mutations.

Luo, J., Wu, S. J., Lacy, E. R., Orlovsky, Y., Baker, A., Teplyakov, A., ... & Benson, J. (2010). Structural basis for the dual recognition of IL-12 and IL-23 by ustekinumab. Journal of molecular biology, 402(5), 797-812.


Specifications

  • Immunogen
  • The details of the immunogen for this antibody are not available.
  • Host Species
  • Human
  • Derivation
  • Human
  • Type
  • IgG1 - kappa
  • Specificity
  • Tested positive against native human antigen.
  • Species Reactivity
  • Human
  • Applications
  • WB, FuncS, IF, Neut, ELISA, FC, IP
  • Trade name
  • stelara
  • CAS
  • 815610-63-0
  • Generic Name
  • Ustekinumab
  • Biological Half-Life
  • 15–32 days (average 3 weeks)
  • ATC Code
  • L04AC05
  • UNII
  • FU77B4U5Z0
  • ChEMBL
  • CHEMBL1201835
  • MW
  • 145.64 kDa
  • Related Disease
  • Inflammatory diseases

Product Property

  • Purity
  • >95%, by SDS-PAGE with silver staining, under reducing conditions.
  • Storage
  • Store at 4°C for up to 3 months. For longer term storage aliquot into small volumes and store at -20°C.

Applications

  • Application Notes
  • The IL12+IL23 antibody has been reported in applications of Activ, ELISA.

Target

  • Alternative Names
  • Ustekinumab;stelara;815610-63-0;CNTO 1275;TT-20;C01275;CNTO 1275;Centocor;Stelara;CNTO 1275;IL12B;interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40);NKSF2;interleukin-12 subunit beta;CLMF;CLMF2;cytoto

Related Resources

  • Biosimilar Overview
Please refer to Ustekinumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Ustekinumab.

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "Ustekinumab"

Afuco™ Anti-IL12+IL23 ADCC Recombinant Antibody (Ustekinumab), ADCC Enhanced
This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to IL12+IL23. Ustekinumab (INN, experimental name CNTO 1275, proprietary commercial name Stelara, Centocor) is a human monoclonal antibody. It is directed against interleukin 12 and interleukin 23, naturally occurring proteins that regulate the immune system and immune-mediated inflammatory disorders.

See other products for "IL12+IL23"

Single-domain Antibody

CAT Product Name Application Type
NAB-1410-VHH Recombinant Anti-Human IL12+IL23 VHH Single Domain Antibody WB, IP, ChiP, Neut, ELISA Llama VHH

Human Antibody

CAT Product Name Application Type
TAB-103 Anti-Human IL12+IL23 Recombinant Antibody (Briakinumab) WB, FC, IP, ELISA, Neut, FuncS, IF IgG1 - lambda

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-063 Afuco™ Anti-IL12+IL23 ADCC Recombinant Antibody (Ustekinumab), ADCC Enhanced FuncS, IF, Neut, ELISA, FC ADCC enhanced antibody
AFC-TAB-103 Afuco™ Anti-IL12+IL23 ADCC Recombinant Antibody (Briakinumab), ADCC Enhanced FC, IP, ELISA, Neut, FuncS ADCC enhanced antibody

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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