Anti-Human IL17A Recombinant Antibody (Secukinumab) (CAT#: TAB-069)

Recombinant monoclonal antibody to IL17A. Secukinumab is a human monoclonal antibody designed for the treatments of uveitis, rheumatoid arthritis, and psoriasis. It targets member A from the cytokine family of interleukin 17.


Specific Inquiry
  • Size:
  • Conjugation:
  • Endotoxin:
  • Purity:
  • Fc Engineering:
  • Published Data
  • Tested Data
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
IHC

Figure 1 The Immunostaining of IL17 receptors are expressed in human astrocytes.

Figure 1 The Immunostaining of IL17 receptors are expressed in human astrocytes.

Scale bar 20 um, Hoechst was used as nuclear stain.

Elain, G., Jeanneau, K., Rutkowska, A., Mir, A. K., & Dev, K. K. (2014). The selective anti‐IL17A monoclonal antibody secukinumab (AIN457) attenuates IL17A‐induced levels of IL6 in human astrocytes. Glia, 62(5), 725-735.

FC

Figure 2 FACs analysis of IL17 receptors are expressed in human astrocytes.

Figure 2 FACs analysis of IL17 receptors are expressed in human astrocytes.

The data showed expression of IL17RA and IL17RC in human astrocytes.

Elain, G., Jeanneau, K., Rutkowska, A., Mir, A. K., & Dev, K. K. (2014). The selective anti‐IL17A monoclonal antibody secukinumab (AIN457) attenuates IL17A‐induced levels of IL6 in human astrocytes. Glia, 62(5), 725-735.

ELISA

Figure 3 ELISA analysis of IL17A expression in mouse astrocytes.

Figure 3 ELISA analysis of IL17A expression in mouse astrocytes.

IL17A increases the levels of IL6 in mouse astrocytes.

Elain, G., Jeanneau, K., Rutkowska, A., Mir, A. K., & Dev, K. K. (2014). The selective anti‐IL17A monoclonal antibody secukinumab (AIN457) attenuates IL17A‐induced levels of IL6 in human astrocytes. Glia, 62(5), 725-735.

IF

Figure 4 Effects of Secukinumab on IL17A/TNFa-induced NF-jB activation.

Figure 4 Effects of Secukinumab on IL17A/TNFa-induced NF-jB activation.

The differences between treated and nontreated cells can be more easily seen in the black
and white "co-localizing pixels" where only the nuclei can be seen and the intensity of white is proportional to the amount of NFkB
present in these nuclei.

Elain, G., Jeanneau, K., Rutkowska, A., Mir, A. K., & Dev, K. K. (2014). The selective anti‐IL17A monoclonal antibody secukinumab (AIN457) attenuates IL17A‐induced levels of IL6 in human astrocytes. Glia, 62(5), 725-735.


Specifications

  • Immunogen
  • HuIL-17 coupled 10 KLH mixed 1:1 with huIL-17 in Gerbu adjuvant.
  • Host Species
  • Human
  • Derivation
  • Human
  • Type
  • IgG1 - kappa
  • Specificity
  • Tested positive against native human antigen.
  • Species Reactivity
  • Human
  • Applications
  • IF, IHC, ELISA, FC
  • Trade name
  • Cosentyx
  • CAS
  • 875356-43-7
  • Generic Name
  • Secukinumab
  • ATC Code
  • L04AC10
  • DrugBank
  • DB09029
  • MW
  • 147.94 kDa
  • Related Disease
  • Psoriatic arthritis (PSA)

Product Property

  • Purity
  • >95.0% as determined by Analysis by RP-HPLC & analysis by SDS-PAGE.
  • Storage
  • At -20°C for one year.

Applications

  • Application Notes
  • The IL17A antibody has been reported in applications of Immunofluorescence, Immunohistochemistry, Enzyme-linked Immunosorbent Assay, Flow Cytometry. FC: The isotype, IL17RA AlexaFluor 647 and IL17RC AlexaFluor 488 antibodies were used at 4mg/ml and 10mg/ml respectively for FACs analysis.

Target

  • Alternative Names
  • Secukinumab;Cosentyx;875356-43-7;AIN457;DB09029IL17A;interleukin 17A;CTLA8, IL17, interleukin 17 (cytotoxic T lymphocyte associated serine esterase 8);interleukin-17A;cytotoxic T lymphocyte associated protein 8;IL 17;IL 17A;CTLA-8;cytotoxic T-lymphocyte-a

Related Resources

  • Biosimilar Overview
  • Related Diseases
Please refer to Secukinumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Secukinumab.

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "Secukinumab"

Afuco™ Anti-IL17A ADCC Recombinant Antibody (Secukinumab), ADCC Enhanced
This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to IL17A. Secukinumab is a human monoclonal antibody designed for the treatments of uveitis, rheumatoid arthritis, and psoriasis. It targets member A from the cytokine family of interleukin 17.

See other products for "IL17A"

Humanized Antibody

CAT Product Name Application Type
TAB-H57 Anti-Human IL17A Recombinant Antibody (Perakizumab) WB, ELISA, IP, FC, FuncS, Neut, IF IgG1 - kappa
TAB-H08 Anti-Human IL17A Recombinant Antibody (Bimekizumab) ELISA, FC, IP, FuncS, IF, Neut, WB IgG1 - kappa
TAB-048ZJ Human Anti-IL17A Recombinant Antibody (TAB-048ZJ) ELISA, Neut Humanized antibody
TAB-048ZJ-S(P) Human Anti-IL17A Recombinant Antibody; scFv Fragment (TAB-048ZJ-S(P)) ELISA, Neut Human scFv
TAB-458CQ Anti-Human IL17A Recombinant Antibody (Vunakizumab) ELISA, IHC, FC, IP, IF, Inhib IgG1, κ

Rat Antibody

CAT Product Name Application Type
TAB-399CL Human Anti-IL17A Recombinant Antibody (TAB-399CL) ELISA Human IgG

Fc Glycosylation

CAT Product Name Application Type
Gly-077LC Recombinant Anti-Human IL17A Antibody (Fc glycosylation) ELISA Humanized antibody

Chicken IgY Antibody

CAT Product Name Application Type
BRD-0289MZ Chicken Anti-Interleukin-17a Polyclonal IgY Indirect ELISA, WB Chicken antibody

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-458CQ Afuco™ Anti-IL17A ADCC Recombinant Antibody (Vunakizumab), ADCC Enhanced ELISA, IHC, FC, IP, IF, Inhib ADCC enhanced antibody
AFC-TAB-069 Afuco™ Anti-IL17A ADCC Recombinant Antibody (Secukinumab), ADCC Enhanced FC, IP, ELISA, Neut, FuncS, IF ADCC enhanced antibody
AFC-TAB-H08 Afuco™ Anti-IL17A ADCC Recombinant Antibody (Bimekizumab), ADCC Enhanced ELISA, FC, IP, FuncS, IF, Neut ADCC enhanced antibody
AFC-TAB-H57 Afuco™ Anti-IL17A ADCC Recombinant Antibody (Perakizumab), ADCC Enhanced ELISA, IP, FC, FuncS, Neut ADCC enhanced antibody

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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