Recombinant monoclonal antibody to IL17A. Secukinumab is a human monoclonal antibody designed for the treatments of uveitis, rheumatoid arthritis, and psoriasis. It targets member A from the cytokine family of interleukin 17.
Figure 1 The Immunostaining of IL17 receptors are expressed in human astrocytes.
Scale bar 20 um, Hoechst was used as nuclear stain.
Elain, G., Jeanneau, K., Rutkowska, A., Mir, A. K., & Dev, K. K. (2014). The selective anti‐IL17A monoclonal antibody secukinumab (AIN457) attenuates IL17A‐induced levels of IL6 in human astrocytes. Glia, 62(5), 725-735.
Figure 2 FACs analysis of IL17 receptors are expressed in human astrocytes.
The data showed expression of IL17RA and IL17RC in human astrocytes.
Elain, G., Jeanneau, K., Rutkowska, A., Mir, A. K., & Dev, K. K. (2014). The selective anti‐IL17A monoclonal antibody secukinumab (AIN457) attenuates IL17A‐induced levels of IL6 in human astrocytes. Glia, 62(5), 725-735.
Figure 3 ELISA analysis of IL17A expression in mouse astrocytes.
IL17A increases the levels of IL6 in mouse astrocytes.
Elain, G., Jeanneau, K., Rutkowska, A., Mir, A. K., & Dev, K. K. (2014). The selective anti‐IL17A monoclonal antibody secukinumab (AIN457) attenuates IL17A‐induced levels of IL6 in human astrocytes. Glia, 62(5), 725-735.
Figure 4 Effects of Secukinumab on IL17A/TNFa-induced NF-jB activation.
The differences between treated and nontreated cells can be more easily seen in the black
and white "co-localizing pixels" where only the nuclei can be seen and the intensity of white is proportional to the amount of NFkB
present in these nuclei.
Elain, G., Jeanneau, K., Rutkowska, A., Mir, A. K., & Dev, K. K. (2014). The selective anti‐IL17A monoclonal antibody secukinumab (AIN457) attenuates IL17A‐induced levels of IL6 in human astrocytes. Glia, 62(5), 725-735.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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Afuco™ Anti-IL17A ADCC Recombinant Antibody (Secukinumab), ADCC EnhancedThis product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to IL17A. Secukinumab is a human monoclonal antibody designed for the treatments of uveitis, rheumatoid arthritis, and psoriasis. It targets member A from the cytokine family of interleukin 17.
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-H57 | Anti-Human IL17A Recombinant Antibody (Perakizumab) | WB, ELISA, IP, FC, FuncS, Neut, IF | IgG1 - kappa |
TAB-H08 | Anti-Human IL17A Recombinant Antibody (Bimekizumab) | ELISA, FC, IP, FuncS, IF, Neut, WB | IgG1 - kappa |
TAB-048ZJ | Human Anti-IL17A Recombinant Antibody (TAB-048ZJ) | ELISA, Neut | Humanized antibody |
TAB-048ZJ-S(P) | Human Anti-IL17A Recombinant Antibody; scFv Fragment (TAB-048ZJ-S(P)) | ELISA, Neut | Human scFv |
TAB-458CQ | Anti-Human IL17A Recombinant Antibody (Vunakizumab) | ELISA, IHC, FC, IP, IF, Inhib | IgG1, κ |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-399CL | Human Anti-IL17A Recombinant Antibody (TAB-399CL) | ELISA | Human IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
PABL-237 | Human Anti-IL17A Recombinant Antibody (clone CNTO7357) | WB, IHC, FuncS | Human IgG |
PABL-238 | Human Anti-IL17A Recombinant Antibody (clone Fab6785) | WB, ELISA, FuncS | Human IgG |
PABW-176 | Human Anti-IL17A Recombinant Antibody (PABW-176) | Neut, ELISA, WB | Human IgG |
MOB-1196MZ | Recombinant Mouse Anti-Human IL17A Antibody (clone 2I7) | WB | Mouse antibody |
HPAB-0207-LSX | Human Anti-IL17A Recombinant Antibody (HPAB-0207-LSX) | ELISA | Human IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
PFBL-237 | Human Anti-IL17A Recombinant Antibody (clone CNTO7357); Fab Fragment | WB, IHC, FuncS | Human Fab |
PFBL-238 | Human Anti-IL17A Recombinant Antibody (clone Fab6785); Fab Fragment | WB, ELISA, FuncS | Human Fab |
HPAB-0207-LSX-F(E) | Human Anti-IL17A Recombinant Antibody; Fab Fragment (HPAB-0207-LSX-F(E)) | ELISA | Human Fab |
HPAB-0208-LSX-F(E) | Human Anti-IL17A Recombinant Antibody; Fab Fragment (HPAB-0208-LSX-F(E)) | ELISA | Human Fab |
HPAB-0209-LSX-F(E) | Human Anti-IL17A Recombinant Antibody; Fab Fragment (HPAB-0209-LSX-F(E)) | ELISA | Chimeric Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-030ZJ | Mouse Anti-IL17A Recombinant Antibody (TAB-030ZJ) | ELISA, Neut | Mouse IgG |
TAB-030ZJ-S(P) | Mouse Anti-IL17A Recombinant Antibody; scFv Fragment (TAB-030ZJ-S(P)) | ELISA, Neut | Mouse scFv |
TAB-030ZJ-F(E) | Mouse Anti-IL17A Recombinant Antibody; Fab Fragment (TAB-030ZJ-F(E)) | ELISA, Neut | Mouse Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-078ZJ-F(E) | Human Anti-IL17A Recombinant Antibody; Fab Fragment (TAB-078ZJ-F(E)) | ELISA, Block, Neut | Human Fab |
TAB-079ZJ-F(E) | Human Anti-IL17A Recombinant Antibody; Fab Fragment (TAB-079ZJ-F(E)) | ELISA, Block, Neut | Human Fab |
TAB-080ZJ-F(E) | Human Anti-IL17A Recombinant Antibody; Fab Fragment (TAB-080ZJ-F(E)) | ELISA, Block, Neut | Human Fab |
PABX-116 | Recombinant Human Anti-Il-17A Antibody (CAT-2200) | WB, ELISA, FuncS | IgG |
PABX-116-S (P) | Recombinant Human Anti-Il-17A Antibody scFv Fragment (CAT-2200) | WB, ELISA, FuncS | scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
Gly-077LC | Recombinant Anti-Human IL17A Antibody (Fc glycosylation) | ELISA | Humanized antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
BRD-0289MZ | Chicken Anti-Interleukin-17a Polyclonal IgY | Indirect ELISA, WB | Chicken antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-1203CQ | Mouse Anti-IL17A Recombinant Antibody (clone M273) | Neut | Mouse IgG1 |
NEUT-1204CQ | Mouse Anti-IL17A Recombinant Antibody (clone 403D10.01) | Neut, FC | Mouse IgG1 |
NEUT-1205CQ | Mouse Anti-IL17A Recombinant Antibody (clone 408H6.01) | Neut, ELISA, FC | Mouse IgG2a |
NEUT-1206CQ | Mouse Anti-IL17A Recombinant Antibody (clone 409H7.05) | Neut, FC | Mouse IgG1 |
NEUT-1207CQ | Mouse Anti-IL17A Recombinant Antibody (clone 412G6.06) | Neut, ELISA, FC | Mouse IgG1 |
CAT | Product Name | Application | Type |
---|---|---|---|
NS-042CN | Mouse Anti-IL17A Recombinant Antibody (NS-042CN) | ELISA, FC | Mouse IgG |
NS-042CN-F(E) | Mouse Anti-IL17A Recombinant Antibody; Fab Fragment (NS-042CN-F(E)) | ELISA, FC | Mouse Fab |
NS-042CN-S(P) | Mouse Anti-IL17A Recombinant Antibody; scFv Fragment (NS-042CN-S(P)) | ELISA, FC | Mouse scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
AFC-TAB-458CQ | Afuco™ Anti-IL17A ADCC Recombinant Antibody (Vunakizumab), ADCC Enhanced | ELISA, IHC, FC, IP, IF, Inhib | ADCC enhanced antibody |
AFC-TAB-069 | Afuco™ Anti-IL17A ADCC Recombinant Antibody (Secukinumab), ADCC Enhanced | FC, IP, ELISA, Neut, FuncS, IF | ADCC enhanced antibody |
AFC-TAB-H08 | Afuco™ Anti-IL17A ADCC Recombinant Antibody (Bimekizumab), ADCC Enhanced | ELISA, FC, IP, FuncS, IF, Neut | ADCC enhanced antibody |
AFC-TAB-H57 | Afuco™ Anti-IL17A ADCC Recombinant Antibody (Perakizumab), ADCC Enhanced | ELISA, IP, FC, FuncS, Neut | ADCC enhanced antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0586-WJ-S(P) | Human Anti-IL17A Recombinant Antibody; scFv Fragment (HPAB-0586-WJ-S(P)) | ELISA | Human scFv |
HPAB-0459-YJ-S(P) | Human Anti-IL17A Recombinant Antibody (clone A13M); scFv Fragment | ELISA, FC, Neut, FuncS | Human scFv |
HPAB-0460-YJ-S(P) | Mouse Anti-IL17A Recombinant Antibody; scFv Fragment (HPAB-0460-YJ-S(P)) | ELISA, Inhib | Mouse scFv |
HPAB-0461-YJ-S(P) | Human Anti-IL17A Recombinant Antibody; scFv Fragment (HPAB-0461-YJ-S(P)) | ELISA, Inhib | Humanized scFv |
HPAB-1747-FY-F(E) | Mouse Anti-IL17A Recombinant Antibody; Fab Fragment (HPAB-1747-FY-F(E)) | WB, ELISA | Mouse Fab |
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