Anti-Human IL1Beta Recombinant Antibody (Canakinumab) (CAT#: TAB-021)
Recombinant monoclonal antibody to Human IL1 beta. Canakinumab (INN, trade name Ilaris, previously ACZ885) is a human monoclonal antibody targeted at interleukin-1 beta. It has no cross-reactivity with other members of the interleukin-1 family, including interleukin-1 alpha.
Canakinumab was for the treatment of rheumatoid arthritis. Canakinumab is as a possible treatment for chronic obstructive pulmonary disease, gout and coronary artery disease.
Specific Inquiry
ELISA
Figure 1 Human IL1 Beta Therapeutic Antibody (TAB-021) in ELISA
ELISA analysis of TAB-021 was performed by coating with Recombinant Human IL1 Beta.
WB
Figure 2 Human IL1 Beta Therapeutic Antibody (TAB-021) in WB
Western blot analysis of TAB-021 was performed with Recombinant Human IL1 Beta.
Lane 1: Non-Reducing Antigen (1ug)
Lane 2: Reducing Antigen (1ug)
Specifications
- Immunogen
- Recombinant human ILI beta
- Host Species
- Human
- Derivation
- Human
- Type
- IgG1 - kappa
- Specificity
- Tested positive against native human antigen
- Species Reactivity
- Human
- Applications
- Suitable for use in FC, IP, ELISA, Neut, FuncS, IF, IHC and most other immunological methods.
- Trade name
- ilaris
- CAS
- 914613-48-2
- Generic Name
- Canakinumab
- ATC Code
- L04AC08
- DrugBank
- DB06168
- UNII
- 37CQ2C7X93
- ChEMBL
- CHEMBL1201834
- MW
- 145.2 kDa
- Related Disease
- Rheumatoid arthritis (RA)
Product Property
- Purity
- Purity >95% by SDS-PAGE.
- Storage
- Store at -20°C. Avoid multiple freeze/thaw cycles.
Target
- Alternative Names
- Canakinumab;ilaris;914613-48-2;ACZ885;DB06168Catabolin;H1;Hematopoietin 1;IFN beta inducing factor;IL 1;IL 1 beta;IL 1B;IL-1 beta;IL1 BETA;IL1F2;Interleukin 1 beta;Interleukin 1 beta precursor;Interleukin-1 beta;LAF;OAF;Osteoclast activating factor;OTTHUM
- Gene ID
- 3553
Related Resources
Please refer to Canakinumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Canakinumab.
Rheumatoid Arthritis
Maturity Onset Diabetes of the Young
TNF Signaling Pathway
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "Canakinumab"
Afuco™ Anti-IL1B ADCC Recombinant Antibody (Canakinumab), ADCC EnhancedThis product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to Human IL1 beta. Canakinumab (INN, trade name Ilaris, previously ACZ885) is a human monoclonal antibody targeted at interleukin-1 beta. It has no cross-reactivity with other members of the interleukin-1 family, including interleukin-1 alpha.
Canakinumab was for the treatment of rheumatoid arthritis. Canakinumab is as a possible treatment for chronic obstructive pulmonary disease, gout and coronary artery disease.
See other products for "IL1B"
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-161 | Anti-Human IL1 beta Recombinant Antibody (Gevokizumab) | ELISA, FC, IP, FuncS, IF, Neut, ICC | IgG2 - kappa |
| TAB-233CT-S(P) | Human Anti-IL1B Recombinant Antibody; scFv Fragment (TAB-233CT-S(P)) | ELISA | Humanized scFv |
| TAB-236CT-S(P) | Anti-Human IL-1β (Interleukin 1 beta) Recombinant Antibody scFv Fragment (huSK48-E26) | ELISA, Neut | Humanized antibody |
| TAB-233CT-F(E) | Human Anti-IL1B Recombinant Antibody; Fab Fragment (TAB-233CT-F(E)) | ELISA | Humanized Fab |
| TAB-236CT-F(E) | Anti-Human IL-1β (Interleukin 1 beta) Recombinant Antibody Fab Fragment (huSK48-E26) | ELISA, Neut | Humanized antibody |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBL-603 | Human Anti-IL1B Recombinant Antibody (clone ACZ885); Fab Fragment | Neut | Human Fab |
| HPAB-0241CQ-F(E) | Human Anti-IL1B Recombinant Antibody; Fab Fragment (HPAB-0241CQ-F(E)) | ELISA, FC, Neut | Humanized Fab |
| HPAB-0242CQ-F(E) | Human Anti-IL1B Recombinant Antibody; Fab Fragment (HPAB-0242CQ-F(E)) | ELISA, FC, Neut | Humanized Fab |
| HPAB-0243CQ-F(E) | Human Anti-IL1B Recombinant Antibody; Fab Fragment (HPAB-0243CQ-F(E)) | ELISA, FC, Neut | Humanized Fab |
| HPAB-0244CQ-F(E) | Human Anti-IL1B Recombinant Antibody; Fab Fragment (HPAB-0244CQ-F(E)) | ELISA, FC, Neut | Humanized Fab |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBC-082 | Mouse Anti-IL1B Recombinant Antibody (clone YC128); scFv Fragment | WB, ELISA | Mouse scFv |
| PSBL-603 | Human Anti-IL1B Recombinant Antibody (clone Canakinumab(ACZ885)); scFv Fragment | Neut | Human scFv |
| HPAB-0035-WJ-S(P) | Human Anti-IL1B Recombinant Antibody; scFv Fragment (HPAB-0035-WJ-S(P)) | ELISA | Human scFv |
| HPAB-1266WJ-S(P) | Mouse Anti-IL1B Recombinant Antibody; scFv Fragment (HPAB-1266WJ-S(P)) | ELISA, WB | Mouse scFv |
| HPAB-1861-FY-F(E) | Human Anti-IL1B Recombinant Antibody (clone Hu007); scFv Fragment | Neut | Humanized scFv |
Chimeric Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-232CT | Anti-Human IL-1β (Interleukin 1 beta) Recombinant Antibody (ch47F11) | Inhibition | Chimeric antibody (mouse/human) |
| TAB-237CT | Anti-Human IL-1β (Interleukin 1 beta) Recombinant Antibody (chSK48-E26) | ELISA, Neut | Chimeric antibody (mouse/human) |
| TAB-543LC | Anti-human IL1B Recombinant Antibody, Chimeric (TAB-543LC) | ELISA | Chimeric antibody (mouse/human) |
| TAB-543LC-S(P) | Anti-human IL1B scFv Fragment, Chimeric | ELISA | Chimeric antibody (mouse/human) |
| TAB-543LC-F(E) | Anti-human IL1B Fab Fragment, Chimeric | ELISA | Chimeric antibody (mouse/human) |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-230CT-S(P) | Mouse Anti-IL1B Recombinant Antibody; scFv Fragment (TAB-230CT-S(P)) | ELISA | Mouse scFv |
| TAB-231CT-S(P) | Anti-Human IL-1β (Interleukin 1 beta) Recombinant Antibody scFv Fragment (47F11) | Inhibition | |
| TAB-234CT-S(P) | Rabbit Anti-IL1B Recombinant Antibody; scFv Fragment (TAB-234CT-S(P)) | FC, ELISA, Neut | Rabbit scFv |
| TAB-235CT-S(P) | Anti-Human IL-1β (Interleukin 1 beta) Recombinant Antibody scFv Fragment (SK48-E26) | ELISA, Neut | |
| TAB-234CT-F(E) | Rabbit Anti-IL1B Recombinant Antibody; Fab Fragment (TAB-234CT-F(E)) | FC, ELISA, Neut | Rabbit Fab |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-550LC-S(P) | Anti-human IL1B scFv Fragment (9.5.2) | ELISA | Human antibody |
| TAB-551LC-S(P) | Anti-human IL1B scFv Fragment (5.5.1) | ELISA | Human antibody |
| TAB-552LC-S(P) | Anti-human IL1B scFv Fragment (8.18.1) | ELISA | Human antibody |
| TAB-553LC-S(P) | Anti-human IL1B scFv Fragment (6.20.1) | ELISA | Human antibody |
| TAB-554LC-S(P) | Anti-human IL1B scFv Fragment (6.33.1) | ELISA | Human antibody |
Chicken IgY Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0282MZ | Chicken Anti-Interleukin-1β Polyclonal IgY | WB, Indirect ELISA | Chicken antibody |
Neutralizing Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1271CQ | Recombinant Mouse Anti-IL1B Antibody (CBL665) | Neut | IgG1 |
| NEUT-1272CQ | Mouse Anti-IL1B Recombinant Antibody (clone 4M27) | IHC, Neut, WB | Mouse IgG2 |
| NEUT-1273CQ | Mouse Anti-IL1B Recombinant Antibody (clone 8516.311) | ELISA, WB, Neut | Mouse IgG1 |
| NEUT-1275CQ | Mouse Anti-IL1B Recombinant Antibody (clone 2805R) | ELISA, Neut, WB, ICC | Mouse IgG1 |
| NEUT-1276CQ | Mouse Anti-IL1B Recombinant Antibody (clone CBL697) | Neut, ELISA | Mouse IgG |
Blocking Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1274CQ | Mouse Anti-IL1B Recombinant Antibody (clone B-A15) | Block, FC | Mouse IgG1 |
| NEUT-1285CQ | Mouse Anti-IL1B Recombinant Antibody (clone H1b-27) | ELISA, ELISPOT, Block | Mouse IgG2b, κ |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1798 | Rabbit Anti-IL1B Recombinant Antibody (clone DS1798AB) | WB | Rabbit IgG |
| MOR-4237 | Rabbit Anti-IL1B Recombinant Antibody (clone SI316DS) | ELISA | Rabbit IgG |
| MOR-4238 | Rabbit Anti-IL1B Recombinant Antibody (clone SI317DS) | ELISA | Rabbit IgG |
| MOR-4239 | Rabbit Anti-IL1B Recombinant Antibody (clone SI318DS) | ELISA | Rabbit IgG |
| MOR-4605 | Rabbit Anti-IL1B Recombinant Antibody (clone TH118DS) | WB | Rabbit IgG |
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-021 | Afuco™ Anti-IL1B ADCC Recombinant Antibody (Canakinumab), ADCC Enhanced | ELISA, IP, FC, FuncS, Neut | ADCC enhanced antibody |
| AFC-TAB-161 | Afuco™ Anti-IL1B ADCC Recombinant Antibody (Gevokizumab), ADCC Enhanced | ELISA, FC, IP, FuncS, IF, Neut | ADCC enhanced antibody |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1228-FY | Human Anti-IL1B Recombinant Antibody (HPAB-1228-FY) | Inhib, WB, Neut | Humanized IgG |
| HPAB-1266WJ | Mouse Anti-IL1B Recombinant Antibody (HPAB-1266WJ) | Inhib, WB | Mouse IgG |
| PABS-0021 | Human Anti-IL1B Recombinant Antibody (Clone 4AB007) | ELISA, FuncS | Human IgG |
| ZG-0152U | Mouse Anti-IL1B Recombinant Antibody (clone 5B6H7) | ELISA | Mouse IgG1 |
| VS3-CJ265 | Rabbit Anti-IL1B Recombinant Antibody (VS3-CJ265) | WB, ICC, IF, IHC, FC | Rabbit IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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