Anti-Human IL23 Recombinant Antibody (Tildrakizumab) (CAT#: TAB-875)

Recombinant humanized (from mouse) antibody expressed in CHO binding to human IL23. Tildrakizumab is a monoclonal antibody designed for the treatment of immunologically mediated inflammatory disorders.


Specific Inquiry
  • Size:
  • Conjugation:
  • Endotoxin:
  • Purity:
  • Fc Engineering:
  • Published Data
  • Tested Data
  • Gene Expression
  • Datasheet
  • MSDS
  • COA

Figure 1 Tildrakizumab inhibits IL-23-associated psoriatic skin gene expression.

Figure 1 Tildrakizumab inhibits IL-23-associated psoriatic skin gene expression.

Four-millimetre lesional (filled circles) and non-lesional (open circles) punch biopsies were taken before dosing and after three tildrakizumab doses or placebo. Lysates were prepared from biopsy sections for analysis on the NanoString nCounter gene expression platform. Skin biopsies were analysed from patients on placebo, 3 mg kg 21 tildrakizumab or 10 mg kg 21 tildrakizumab.

Kopp, T. , Riedl, E. , Bangert, C. , Bowman, E. , Greisenegger, E. , & Horowitz, A. , et al. (2015). A rising multiple-dose tolerability, safety, and pharmacokinetic study of intravenous tildrakizumab in patients with psoriasis.


Specifications

  • Immunogen
  • The details of the immunogen for this antibody are not available.
  • Host Species
  • Mouse
  • Derivation
  • Humanized (from mouse)
  • Type
  • IgG1 - kappa
  • Species Reactivity
  • Human
  • Applications
  • Neut, ELISA, IF, IP, FuncS, FC, ICC
  • CAS
  • 1326244-10-3
  • Generic Name
  • Tildrakizumab
  • MW
  • 144.4 kDa
  • Related Disease
  • Psoriasis

Product Property

  • Purity
  • >95.0%. Determined by analysis by RP-HPLC & analysis by SDS-PAGE.
  • Storage
  • At -20°C for one year.

Applications

  • Application Notes
  • The IL23A antibody has been reported in applications of Inhib.

Target

  • Alternative Names
  • Tildrakizumab;1326244-10-3;MK-3222;SCH 900222;IL23A;interleukin 23, alpha subunit p19;interleukin-23 subunit alpha;IL 23;IL 23A;IL23P19;interleukin six;G CSF related factor;P19;SGRF;IL-23-A;IL-23p19;IL-23 subunit alpha;interleukin 23 p19 subunit;interleuk

Related Resources

  • Biosimilar Overview
Please refer to Tildrakizumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Tildrakizumab.

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "Tildrakizumab"

Afuco™ Anti-IL23A ADCC Recombinant Antibody (Tildrakizumab), ADCC Enhanced
This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant humanized (from mouse) antibody expressed in CHO binding to human IL23. Tildrakizumab is a monoclonal antibody designed for the treatment of immunologically mediated inflammatory disorders.

See other products for "IL23A"

Single-domain Antibody

CAT Product Name Application Type
NAB-1953-VHH Recombinant Anti-human IL23A VHH Single Domain Antibody WB, IP, ICC, FC, FA Llama VHH
TAB-005LC-VHH Anti-human IL23A Recombinant Antibody (119A3) (TAB-005LC-VHH) ELISA Single domain antibody

Chimeric Antibody

CAT Product Name Application Type
TAB-607LC Anti-human IL23A Recombinant Antibody (E11E7Chimera) (TAB-607LC) ELISA, Neut, FuncS Chimeric antibody (rat/human)
TAB-607LC-S(P) Anti-human IL23A scFv Fragment (E11E7Chimera) ELISA Chimeric antibody (rat/human)
TAB-607LC-F(E) Anti-human IL23A Fab Fragment (E11E7Chimera) ELISA Chimeric antibody (rat/human)

Humanized Antibody

CAT Product Name Application Type
TAB-616LC Anti-human IL23A Recombinant Antibody (A3M0) (TAB-616LC) ELISA, FC, Inhib, FuncS Humanized antibody
TAB-617LC Anti-human IL23A Recombinant Antibody (A3M1) (TAB-617LC) ELISA, FC, Inhib Humanized antibody
TAB-618LC Anti-human IL23A Recombinant Antibody (A3N1) (TAB-618LC) ELISA, FC, Inhib Humanized antibody
TAB-605LC-S(P) Anti-human IL23A scFv Fragment (FM303) ELISA Humanized antibody
TAB-608LC-S(P) Anti-human IL23A scFv Fragment (21-4) ELISA Humanized antibody

Rabbit Monoclonal Antibody

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-875 Afuco™ Anti-IL23A ADCC Recombinant Antibody (Tildrakizumab), ADCC Enhanced Neut, ELISA, IF, IP, FuncS, FC ADCC enhanced antibody
AFC-TAB-620LC Afuco™ Anti-IL23A ADCC Recombinant Antibody (Risankizumab), ADCC Enhanced ELISA ADCC enhanced antibody
AFC-TAB-008ML Afuco™ Anti-IL23A ADCC Recombinant Antibody (Brazikumab), ADCC Enhanced ELISA, IHC, FC, IP, IF, Inhib ADCC enhanced antibody

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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