Anti-Human IgE Fc Recombinant Antibody (Talizumab) (CAT#: TAB-886)

Recombinant humanized (from mouse) antibody expressed in CHO binding to human IgE Fc. Talizumab is a humanized monoclonal antibody as a new-concept therapeutic for allergic diseases. The unique anti-IgE antibody was designed to target immunoglobulin E (IgE) and IgE-expressing B lymphocytes specifically, without binding to IgE already bound by the high affinity IgE receptors on mast cells and basophils.


Specific Inquiry
  • Size:
  • Conjugation:
  • Endotoxin:
  • Purity:
  • Fc Engineering:
  • Tested Data
  • Datasheet
  • MSDS
  • COA
WB

Figure 1 Anti-Human IgE Fc Antibody (TAB-886) in WB

Figure 1 Anti-Human IgE Fc Antibody (TAB-886) in WB

Western blot analysis of TAB-886 was performed by loading recombinant human IgE Fc protein in reduced condition Lane 1, Lane 2 and Lane 3 (0.1 μg, 0.3 μg and 0.6 μg respectively) onto a 12% Tris-HCl polyacrylamide gel. Proteins were transferred to a CN membrane and blocked with 5% skim milk for at least one hour. Membranes were probed with TAB-886 (2 μg/mL) and HRP-conjugated goat anti-Human IgG (H&L) as a secondary antibody (1: 5000). Chemiluminescent detection was performed.

DB

Figure 2 Anti-Human IgE Fc Antibody (TAB-886) in DB

Figure 2 Anti-Human IgE Fc Antibody (TAB-886) in DB

Dot Blot analysis of TAB-886 was performed by coating with recombinant human IgE Fc protein.
TAB-886 incubation concentration: 2 μg/mL.
HRP-conjugated goat anti-Human IgG (H&L) as a secondary antibody (1: 5000)
NC: Negative Control PC: Positive Control

ELISA

Figure 3 Anti-Human IgE Fc Antibody (TAB-886) in ELISA

Figure 3 Anti-Human IgE Fc Antibody (TAB-886) in ELISA

ELISA analysis of TAB-886 was performed by coating with recombinant human IgE Fc protein. Then blocked with BSA and incubated with TAB-886. The HRP-conjugated goat anti-Human IgG as a secondary antibody (1: 5000). Detection was performed using TMB substrate and stopped with sulfuric acid. The absorbances were read on a spectrophotometer at 450 nm.


Specifications

  • Immunogen
  • The details of the immunogen for this antibody are not available.
  • Host Species
  • Mouse
  • Derivation
  • Humanized (from mouse)
  • Type
  • IgG1
  • Species Reactivity
  • Human
  • Applications
  • Suitable for use in IF, IP, Neut, FuncS, ELISA, FC, ICC and most other immunological methods.
  • CAS
  • 380610-22-0
  • Generic Name
  • Talizumab
  • UNII
  • 9591BL735Z
  • Related Disease
  • Peanut allergy (severe)

Product Property

  • Purity
  • Purity >95% by SDS-PAGE.
  • Storage
  • Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

  • Alternative Names
  • Talizumab;380610-22-0;TNX-901;Hu901;CGP-5101;CL-5I;TNX-901;IgE Fc;IgE;Immunoglobulin E;Immunoglobulin E Fc

Related Resources

  • Biosimilar Overview
Please refer to Talizumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Talizumab.

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "Talizumab"

Afuco™ Anti-IgE Fc ADCC Recombinant Antibody (Talizumab), ADCC Enhanced
This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant humanized (from mouse) antibody expressed in CHO binding to human IgE Fc. Talizumab is a humanized monoclonal antibody as a new-concept therapeutic for allergic diseases. The unique anti-IgE antibody was designed to target immunoglobulin E (IgE) and IgE-expressing B lymphocytes specifically, without binding to IgE already bound by the high affinity IgE receptors on mast cells and basophils.

See other products for "IgE Fc"

Single-domain Antibody

CAT Product Name Application Type
NAB-1378-VHH Recombinant Anti-Human IgE Fc VHH Single Domain Antibody IHC, IP, FC, Neut, FUNC Llama VHH
PABC-586 Recombinant Llama Anti-IgE Fc Single Domain Antibody (026) ELISA, FC, SPR Llama VHH

Recombinant Antibody

CAT Product Name Application Type
PABL-230 Human Anti-IgE Fc Recombinant Antibody (clone MEDI4212) ELISA, WB, Neut, FuncS Human IgG
PABC-341 Human Anti-IgE Fc Recombinant Antibody (clone 8D6) FC Human IgG

scFv Fragment Antibody

Fab Fragment Antibody

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-886 Afuco™ Anti-IgE Fc ADCC Recombinant Antibody (Talizumab), ADCC Enhanced IF, IP, Neut, FuncS, ELISA, FC ADCC enhanced antibody

Customer Reviews and Q&As

Submit a review or a question
There are currently no Customer reviews or questions for TAB-886. Click the button above to contact us or submit your feedback about this product.
View the frequently asked questions answered by Creative Biolabs Support.

For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Send Inquiry

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

© 2024 Creative Biolabs.
  • 0
  • 0
Cart

    Go to compare