Recombinant humanized (from mouse) antibody expressed in CHO binding to human IgE Fc. Talizumab is a humanized monoclonal antibody as a new-concept therapeutic for allergic diseases. The unique anti-IgE antibody was designed to target immunoglobulin E (IgE) and IgE-expressing B lymphocytes specifically, without binding to IgE already bound by the high affinity IgE receptors on mast cells and basophils.
Figure 1 Anti-Human IgE Fc Antibody (TAB-886) in WB
Western blot analysis of TAB-886 was performed by loading recombinant human IgE Fc protein in reduced condition Lane 1, Lane 2 and Lane 3 (0.1 μg, 0.3 μg and 0.6 μg respectively) onto a 12% Tris-HCl polyacrylamide gel. Proteins were transferred to a CN membrane and blocked with 5% skim milk for at least one hour. Membranes were probed with TAB-886 (2 μg/mL) and HRP-conjugated goat anti-Human IgG (H&L) as a secondary antibody (1: 5000). Chemiluminescent detection was performed.
Figure 2 Anti-Human IgE Fc Antibody (TAB-886) in DB
Dot Blot analysis of TAB-886 was performed by coating with recombinant human IgE Fc protein.
TAB-886 incubation concentration: 2 μg/mL.
HRP-conjugated goat anti-Human IgG (H&L) as a secondary antibody (1: 5000)
NC: Negative Control PC: Positive Control
Figure 3 Anti-Human IgE Fc Antibody (TAB-886) in ELISA
ELISA analysis of TAB-886 was performed by coating with recombinant human IgE Fc protein. Then blocked with BSA and incubated with TAB-886. The HRP-conjugated goat anti-Human IgG as a secondary antibody (1: 5000). Detection was performed using TMB substrate and stopped with sulfuric acid. The absorbances were read on a spectrophotometer at 450 nm.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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Afuco™ Anti-IgE Fc ADCC Recombinant Antibody (Talizumab), ADCC EnhancedThis product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant humanized (from mouse) antibody expressed in CHO binding to human IgE Fc. Talizumab is a humanized monoclonal antibody as a new-concept therapeutic for allergic diseases. The unique anti-IgE antibody was designed to target immunoglobulin E (IgE) and IgE-expressing B lymphocytes specifically, without binding to IgE already bound by the high affinity IgE receptors on mast cells and basophils.
CAT | Product Name | Application | Type |
---|---|---|---|
NAB-1378-VHH | Recombinant Anti-Human IgE Fc VHH Single Domain Antibody | IHC, IP, FC, Neut, FUNC | Llama VHH |
PABC-586 | Recombinant Llama Anti-IgE Fc Single Domain Antibody (026) | ELISA, FC, SPR | Llama VHH |
CAT | Product Name | Application | Type |
---|---|---|---|
PABL-230 | Human Anti-IgE Fc Recombinant Antibody (clone MEDI4212) | ELISA, WB, Neut, FuncS | Human IgG |
PABC-341 | Human Anti-IgE Fc Recombinant Antibody (clone 8D6) | FC | Human IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
PSBL-230 | Human Anti-IgE Fc Recombinant Antibody (clone MEDI4212); scFv Fragment | ELISA, WB, Neut, FuncS | Human scFv |
PSBC-341 | Human Anti-IgE Fc Recombinant Antibody (clone 8D6); scFv Fragment | FC, Inhib | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
PFBL-230 | Human Anti-IgE Fc Recombinant Antibody (clone MEDI4212); Fab Fragment | ELISA, WB, Neut, FuncS | Human Fab |
PFBC-341 | Human Anti-IgE Fc Recombinant Antibody (clone 8D6); Fab Fragment | FC, Inhib | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
AFC-TAB-886 | Afuco™ Anti-IgE Fc ADCC Recombinant Antibody (Talizumab), ADCC Enhanced | IF, IP, Neut, FuncS, ELISA, FC | ADCC enhanced antibody |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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