Recombinant Humanized (from mouse) antibody to Human MET
Figure 1 Waterfall plot for best response and treatment duration.
A, Waterfall plot of maximum percent change in sum of target lesions relative to baseline for emibetuzumab monotherapy. aThe patient had colorectal cancer. bThe patient had ovarian cancer. cThe patient had adenocarcinoma of colon. Progressive disease due to appearance of new lesions. dThe patient had transitional cell carcinoma. B, Waterfall plot of maximum percent change in sum of target lesions relative to baseline for emibetuzumab + erlotinib. aBoth patients were enrolled to this study immediately following progression on erlotinib monotherapy, having only recorded stable disease during this prior erlotinib treatment. Immunohistochemical analysis of available tumor tissue samples from both patients was positive for MET expression.
Rosen, L. S., Goldman, J. W., Algazi, A. P., Turner, P. K., Moser, B., Hu, T.,... & Banck, M. (2017). A first-in-human phase I study of a bivalent MET antibody, emibetuzumab (LY2875358), as monotherapy and in combination with erlotinib in advanced cancer. Clinical Cancer Research, 23(8), 1910-1919.
Figure 2 MET kinase inhibitors but not emibetuzumab inhibited MET signaling pathway in Hs746t cells in vitro by western blot analysis.
Hs746t cells were treated for 24 h with 133 nM (20 μg/ml) or 667 nM (100 μg/ml) emibetuzumab or MET kinase inhibitors (merestinib, PF04217903, crizotinib, cabozantinib) at 15.6, 62.5, 250 or 1000 Nm.
Rosen, L. S., Goldman, J. W., Algazi, A. P., Turner, P. K., Moser, B., Hu, T.,... & Banck, M. (2017). A first-in-human phase I study of a bivalent MET antibody, emibetuzumab (LY2875358), as monotherapy and in combination with erlotinib in advanced cancer. Clinical Cancer Research, 23(8), 1910-1919.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
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Afuco™ Anti-MET ADCC Recombinant Antibody (Emibetuzumab), ADCC EnhancedThis product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant Humanized (from mouse) antibody to Human MET
CAT | Product Name | Application | Type |
---|---|---|---|
AGTO-G049E | Anti-MET immunotoxin (Fab)-PE | Cytotoxicity assay, Function study |
CAT | Product Name | Application | Type |
---|---|---|---|
PABZ-155 | Afuco™ Anti-MET ADCC Recombinant Antibody (Onartuzumab), ADCC Enhanced | ELISA, Neut | ADCC enhanced antibody |
AFC-TAB-H24 | Afuco™ Anti-MET ADCC Recombinant Antibody (Emibetuzumab), ADCC Enhanced | FuncS, IF, Neut, ELISA, FC, IP | ADCC enhanced antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-002MZ | Anti-Human MET Recombinant Antibody (MvDN30) | IHC, PET imaging | Chimeric antibody (mouse/human) |
TAB-002MZ-S(P) | Anti-Human MET Recombinant Antibody scFv Fragment (MvDN30) | IHC, PET imaging | Chimeric antibody (mouse/human) |
TAB-002MZ-F(E) | Anti-Human MET Recombinant Antibody Fab Fragment (MvDN30) | IHC, PET imaging | Chimeric antibody (mouse/human) |
TAB-0880CLV | Human Anti-MET Recombinant Antibody (TAB-0880CLV) | ELISA, FuncS | Chimeric (mouse/human) IgG1 |
TAB-0880CLV-S(P) | Mouse Anti-MET Recombinant Antibody; scFv Fragment (TAB-0880CLV-S(P)) | ELISA, FuncS | Mouse scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-011MZ | Mouse Anti-MET Recombinant Antibody (TAB-011MZ) | ELISA, WB, FC | Mouse IgG |
TAB-012MZ | Mouse Anti-MET Recombinant Antibody (TAB-012MZ) | ELISA, WB, FC | Mouse IgG |
TAB-027MZ-S(P) | Mouse Anti-MET Recombinant Antibody; scFv Fragment (TAB-027MZ-S(P)) | FC, WB, ELISA | Mouse scFv |
TAB-028MZ-S(P) | Mouse Anti-MET Recombinant Antibody; scFv Fragment (TAB-028MZ-S(P)) | FC, WB, ELISA | Mouse scFv |
TAB-029MZ-S(P) | Mouse Anti-MET Recombinant Antibody; scFv Fragment (TAB-029MZ-S(P)) | FC, WB, ELISA | Mouse scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-017MZ-S(P) | Human Anti-MET Recombinant Antibody; scFv Fragment (TAB-017MZ-S(P)) | ELISA | Human scFv |
TAB-018MZ-S(P) | Human Anti-MET Recombinant Antibody; scFv Fragment (TAB-018MZ-S(P)) | ELISA | Human scFv |
TAB-019MZ-S(P) | Human Anti-MET Recombinant Antibody; scFv Fragment (TAB-019MZ-S(P)) | ELISA | Human scFv |
TAB-020MZ-S(P) | Human Anti-MET Recombinant Antibody; scFv Fragment (TAB-020MZ-S(P)) | ELISA | Human scFv |
TAB-021MZ-S(P) | Human Anti-MET Recombinant Antibody; scFv Fragment (TAB-021MZ-S(P)) | ELISA | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-0885CLV | Human Anti-MET Recombinant Antibody (TAB-0885CLV) | ELISA, FuncS | Humanized IgG1 |
TAB-0881CLV-F(E) | Human Anti-MET Recombinant Antibody; Fab Fragment (TAB-0881CLV-F(E)) | ELISA, FuncS | Humanized Fab |
TAB-0883CLV-F(E) | Human Anti-MET Recombinant Antibody; Fab Fragment (TAB-0883CLV-F(E)) | ELISA, FuncS | Humanized Fab |
TAB-0881CLV-S(P) | Human Anti-MET Recombinant Antibody; scFv Fragment (TAB-0881CLV-S(P)) | ELISA, FuncS | Humanized scFv |
TAB-0883CLV-S(P) | Human Anti-MET Recombinant Antibody; scFv Fragment (TAB-0883CLV-S(P)) | ELISA, FuncS | Humanized scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-1726CQ | Recombinant Rabbit Anti-MET Antibody (CBL1008) | Neut | IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-2216 | Hi-Affi™ Recombinant Rabbit Anti-MET Monoclonal Antibody (DS2216AB) | ICC/IF, IHC-P, WB | IgG |
MOR-4519 | Hi-Affi™ Recombinant Rabbit Anti-MET Monoclonal Antibody (TH27DS) | WB, IF, ICC | IgG |
MOR-4645 | Hi-Affi™ Recombinant Rabbit Anti-MET Monoclonal Antibody (TH158DS) | WB, IF, ICC, FC, ELISA | IgG |
MOR-4694 | Hi-Affi™ Recombinant Rabbit Anti-MET Monoclonal Antibody (TH208DS) | WB, ELISA | IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0071-YC-S(P) | Mouse Anti-MET Recombinant Antibody; scFv Fragment (HPAB-0071-YC-S(P)) | ELISA | Mouse scFv |
HPAB-0072-YC-S(P) | Human Anti-MET Recombinant Antibody; scFv Fragment (HPAB-0072-YC-S(P)) | ELISA | Humanized scFv |
HPAB-0073-YC-S(P) | Human Anti-MET Recombinant Antibody; scFv Fragment (HPAB-0073-YC-S(P)) | ELISA | Human scFv |
HPAB-N0176-YC-S(P) | Mouse Anti-MET Recombinant Antibody; scFv Fragment (HPAB-N0176-YC-S(P)) | ELISA, FC | Mouse scFv |
HPAB-N0177-YC-S(P) | Human Anti-MET Recombinant Antibody; scFv Fragment (HPAB-N0177-YC-S(P)) | ELISA, FC | Humanized scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0071-YC-F(E) | Mouse Anti-MET Recombinant Antibody; Fab Fragment (HPAB-0071-YC-F(E)) | ELISA | Mouse Fab |
HPAB-0072-YC-F(E) | Human Anti-MET Recombinant Antibody; Fab Fragment (HPAB-0072-YC-F(E)) | ELISA | Humanized Fab |
HPAB-0073-YC-F(E) | Human Anti-MET Recombinant Antibody; Fab Fragment (HPAB-0073-YC-F(E)) | ELISA | Human Fab |
HPAB-0077-YC-F(E) | Mouse Anti-MET Recombinant Antibody (clone LMH 89); Fab Fragment | ELISA, FC, Stim, FuncS | Mouse Fab |
HPAB-0760-CN-F(E) | Mouse Anti-MET Recombinant Antibody; Fab Fragment (HPAB-0760-CN-F(E)) | WB, ELISA, IHC, IP | Mouse Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0760-CN | Mouse Anti-MET Recombinant Antibody (HPAB-0760-CN) | WB, ELISA, IHC, IP | Mouse IgG |
HPAB-0761-CN | Human Anti-MET Recombinant Antibody (HPAB-0761-CN) | WB, ELISA, IHC, IP | Chimeric (mouse/human) IgG1, κ |
HPAB-0762-CN | Human Anti-MET Recombinant Antibody (HPAB-0762-CN) | WB, ELISA, IHC, IP | Humanized IgG1, κ |
HPAB-0030-WJ | Human Anti-MET Recombinant Antibody (HPAB-0030-WJ) | ELISA, WB | Human IgG |
HPAB-1298LY | Human Anti-MET Recombinant Antibody (HPAB-1298LY) | ELISA, IP | Human IgG2 |
CAT | Product Name | Application | Type |
---|---|---|---|
MHC-YF474 | A*02:01/Human Hepatocyte growth factor receptor (YVDPVITSI) MHC Pentamer | FCM |
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