Anti-Human Nogo-A Recombinant Antibody (Ozanezumab) (CAT#: TAB-903)
Recombinant humanized (from mouse) antibody expressed in CHO binding to human Nogo-A. Ozanezumab is a monoclonal antibody designed for the treatment of ALS and multiple sclerosis. Ozanezumab targets a protein called Neurite Outgrowth Inhibitor (NOGO-A) or Reticulon 4. NOGO-A is a protein that in humans is encoded by the RTN4 gene that has been identified as an inhibitor of neurite outgrowth specific to the central nervous system. NOGO-A is found at higher than normal levels in persons with MND.
Specific Inquiry
SDS-PAGE
Figure 1 Anti-Human Nogo-A Recombinant Antibody (TAB-903) in SDS-PAGE
SDS-PAGE analysis of TAB-903 in non-reduced (Lane 1) and reduced (Lane 2) conditions.
SEC-HPLC
Figure 2 Anti-Human Nogo-A Recombinant Antibody (TAB-903) in HPLC
HPLC analysis of TAB-903 shows the purity is>95%.
Specifications
- Immunogen
- The details of the immunogen for this antibody are not available.
- Host Species
- Mouse
- Derivation
- Humanized (from mouse)
- Type
- IgG1
- Species Reactivity
- Human
- Applications
- Suitable for use in IF, IP, Neut, FuncS, ELISA, FC, ICC and most other immunological methods.
- CAS
- 1310680-64-8
- Generic Name
- Ozanezumab
- MW
- 145.2 kDa
- Related Disease
- Multiple sclerosis (MS)
Product Property
- Purity
- >95.0%. Determined by analysis by RP-HPLC & analysis by SDS-PAGE.
- Storage
- Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing of samples.
Target
- Alternative Names
- Ozanezumab;1310680-64-8;RTN4;reticulon 4;reticulon-4;ASY;KIAA0886;NOGO;NSP CL;foocen;Human NogoA;reticulon 5;My043 protein;neurite outgrowth inhibitor;neurite growth inhibitor 220;neuroendocrine-specific protein C homolog;NSP;NOGOC;
- Gene ID
- 57142
- UniProt ID
- Q9NQC3
Related Resources
Please refer to Ozanezumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Ozanezumab.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "Ozanezumab"
Afuco™ Anti-RTN4 ADCC Recombinant Antibody (Ozanezumab), ADCC EnhancedThis product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant humanized (from mouse) antibody expressed in CHO binding to human Nogo-A. Ozanezumab is a monoclonal antibody designed for the treatment of ALS and multiple sclerosis. Ozanezumab targets a protein called Neurite Outgrowth Inhibitor (NOGO-A) or Reticulon 4. NOGO-A is a protein that in humans is encoded by the RTN4 gene that has been identified as an inhibitor of neurite outgrowth specific to the central nervous system. NOGO-A is found at higher than normal levels in persons with MND.
See other products for "RTN4"
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2437z | Mouse Anti-RTN4 Recombinant Antibody (clone 28B12) | WB, ELISA, IF, IP | Mouse IgM, κ |
| MOB-2424CT | Recombinant Mouse anti-Human RTN4 Monoclonal antibody (9XH27) | WB, IHC-P, IHC-Fr | |
| MOB-186CQ | Mouse Anti-RTN4 Antibody | ELISA, WB | Mouse IgG1 |
| MRO-1101-CN | Recombinant Rabbit Anti-RTN4 Monoclonal Antibody (JM02-34) | WB, IF, IHC, IP, FC | Rabbit IgG |
| HPAB-0901-FY | Human Anti-RTN4 Recombinant Antibody (HPAB-0901-FY) | ELISA, Neut | Humanized IgG |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-242 | Anti-Human RTN-4 Recombinant Antibody (Atinumab) | ELISA, FC, IP, FuncS, IF, Neut, ICC | IgG4 - kappa |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-531MZ | Anti-Human RTN4 Recombinant Antibody (11C7) | ELISA, ICC | |
| TAB-532MZ | Mouse Anti-RTN4 Recombinant Antibody (TAB-532MZ) | ELISA, FC | Mouse IgG |
| TAB-531MZ-S(P) | Anti-Human RTN4 Recombinant Antibody scFv Fragment (11C7) | ELISA, ICC | |
| TAB-531MZ-F(E) | Anti-Human RTN4 Recombinant Antibody Fab Fragment (11C7) | ELISA, ICC | |
| TAB-532MZ-F(E) | Mouse Anti-RTN4 Recombinant Antibody; Fab Fragment (TAB-532MZ-F(E)) | ELISA, FC | Mouse Fab |
Chimeric Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-533MZ | Human Anti-RTN4 Recombinant Antibody (TAB-533MZ) | ELISA, FC | Chimeric (mouse/human) IgG |
| TAB-533MZ-S(P) | Mouse Anti-RTN4 Recombinant Antibody; scFv Fragment (TAB-533MZ-S(P)) | ELISA, FC | Mouse scFv |
| TAB-533MZ-F(E) | Human Anti-RTN4 Recombinant Antibody; Fab Fragment (TAB-533MZ-F(E)) | ELISA, FC | Chimeric (mouse/human) Fab |
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-534MZ | Human Anti-RTN4 Recombinant Antibody (TAB-534MZ) | ELISA, FC | Humanized IgG |
| TAB-535MZ | Human Anti-RTN4 Recombinant Antibody (TAB-535MZ) | ELISA, FC | Humanized IgG |
| TAB-536MZ | Human Anti-RTN4 Recombinant Antibody (TAB-536MZ) | ELISA, FC | Humanized IgG |
| TAB-537MZ | Human Anti-RTN4 Recombinant Antibody (TAB-537MZ) | ELISA, FC | Humanized IgG |
| TAB-534MZ-F(E) | Human Anti-RTN4 Recombinant Antibody; Fab Fragment (TAB-534MZ-F(E)) | ELISA, FC | Humanized Fab |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3139 | Hi-Affi™ Recombinant Rabbit Anti-RTN4 Monoclonal Antibody (DS3139AB) | WB, FC | IgG |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0294CQ-F(E) | Mouse Anti-RTN4 Recombinant Antibody (clone mAb 3A6); Fab Fragment | ELISA, WB | Mouse Fab |
| HPAB-0295CQ-F(E) | Human Anti-RTN4 Recombinant Antibody (clone h3A6); Fab Fragment | ELISA, WB | Human Fab |
| HPAB-0047-WJ-F(E) | Mouse Anti-RTN4 Recombinant Antibody (clone 6F2); Fab Fragment | ELISA, WB | Mouse Fab |
| HPAB-0901-FY-S(P) | Human Anti-RTN4 Recombinant Antibody; scFv Fragment (HPAB-0901-FY-S(P)) | ELISA, Neut | Humanized scFv |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0294CQ-S(P) | Mouse Anti-RTN4 Recombinant Antibody (clone mAb 3A6); scFv Fragment | ELISA, WB | Mouse scFv |
| HPAB-0295CQ-S(P) | Human Anti-RTN4 Recombinant Antibody (clone h3A6); scFv Fragment | ELISA, WB | Human scFv |
| HPAB-0047-WJ-S(P) | Mouse Anti-RTN4 Recombinant Antibody (clone 6F2); scFv Fragment | ELISA, WB | Mouse scFv |
| HPAB-0901-FY-F(E) | Human Anti-RTN4 Recombinant Antibody; Fab Fragment (HPAB-0901-FY-F(E)) | ELISA, Neut | Humanized Fab |
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-903 | Afuco™ Anti-RTN4 ADCC Recombinant Antibody (Ozanezumab), ADCC Enhanced | IF, IP, Neut, FuncS, ELISA, FC | ADCC enhanced antibody |
| AFC-TAB-242 | Afuco™ Anti-RTN4 ADCC Recombinant Antibody (Atinumab), ADCC Enhanced | ELISA, FC, IP, FuncS, IF, Neut | ADCC enhanced antibody |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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