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Anti-Human VEGF Receptor 2 Recombinant Antibody (Ramucirumab)

Anti-Human VEGF Receptor 2 Recombinant Antibody (Ramucirumab) (CAT#: TAB-079)

Recombinant monoclonal antibody to VEGF Receptor 2. Ramucirumab (IMC-1121B) is a fully human monoclonal antibody (IgG1) for the treatment of solid tumors. It is directed against the vascular endothelial growth factor receptor 2 (VEGFR2). By binding to VEGFR2 it works as a receptor antagonist blocking the binding of vascular endothelial growth factor (VEGF) to VEGFR2. VEGFR2 is known to mediate the majority of the downstream effects of VEGF in angiogenesis.

See more Engineered Antibody products for KDR

Published Data
Gene Expression
Datasheet
MSDS
COA

FC

Figure 1 Impact of anti-VEGFR2 blockade on PBMCs in vitro.

Figure 1 Impact of anti-VEGFR2 blockade on PBMCs in vitro.

VEGFR2 expression in several T-cell subsets.

Tada, Y., Togashi, Y., Kotani, D., Kuwata, T., Sato, E., Kawazoe, A., ... & Shitara, K. (2018). Targeting VEGFR2 with Ramucirumab strongly impacts effector/activated regulatory T cells and CD8+ T cells in the tumor microenvironment. Journal for immunotherapy of cancer, 6(1), 1-14.

Subcellular Location

Figure 1 IF staining of human cell line HEL

Figure 1 IF staining of human cell line HEL
(Immunofluorescent staining of human cell line HEL shows localization to nuclear membrane & vesicles.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/73577/1825_D8_31_cr5ac340707076b_selected.jpg

Normal Tissue

Figure 2 Placenta

Figure 2 Placenta
(High expression)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4028/11467_A_2_7_val_selected.jpg

Figure 3 Colon

Figure 3 Colon
(Endothelial cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4028/11467_A_8_3.jpg

Figure 4 Kidney

Figure 4 Kidney
(Cells in glomeruli Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4028/11467_A_7_5.jpg

Figure 5 Testis

Figure 5 Testis
(Leydig cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4028/11467_A_6_6.jpg

RNA Expression

Figure 6 RNA cell line category: Group enriched (HUVEC TERT2, TIME)

Figure 6 RNA cell line category: Group enriched (HUVEC TERT2, TIME)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000128052-KDR

MSDS

Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number

Specifications

Immunogen
The details of the immunogen for this antibody are not available.

Host Species
Human

Derivation
Human

Type
IgG1 - kappa

Specificity
Tested positive against native human antigen.

Species Reactivity
Human

Applications
FC, IHC

Trade name
Cyramza

CAS
947687-13-0

Generic Name
Ramucirumab

UNII
D99YVK4L0X

MW
143.6 kDa

Related Disease
Non-small cell lung cancers (NSCLC)

Product Property

Purity
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.

Storage
4°C. For long term storage, aliquot and store at -20°C. Repeated thawing and freezing must be avoided.

Applications

Application Notes
The VEGF Receptor 2 antibody has been reported in applications of Immunohistochemistry, Flow Cytometry.

Target

Alternative Names
Ramucirumab;Cyramza;947687-13-0;IMC-1121B;LY3009806;IMC-1121B;Cyramza;KDR;kinase insert domain receptor (a type III receptor tyrosine kinase);vascular endothelial growth factor receptor 2;CD309;FLK1;VEGFR;VEGFR2;soluble VEGFR2;fetal liver kinase 1;fetal l

Gene ID
3791

UniProt ID
P35968

Related Resources

Biosimilar Overview

Please refer to Ramucirumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Ramucirumab.

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "Ramucirumab"

Afuco™ Anti-KDR ADCC Recombinant Antibody (Ramucirumab), ADCC Enhanced
This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to VEGF Receptor 2. Ramucirumab (IMC-1121B) is a fully human monoclonal antibody (IgG1) for the treatment of solid tumors. It is directed against the vascular endothelial growth factor receptor 2 (VEGFR2). By binding to VEGFR2 it works as a receptor antagonist blocking the binding of vascular endothelial growth factor (VEGF) to VEGFR2. VEGFR2 is known to mediate the majority of the downstream effects of VEGF in angiogenesis.

See other products for "KDR"

Intrabody

CAT	Product Name	Application	Type
IAB-B066(A)	Recombinant Anti-human KDR Intrabody [(D-Arg)₉]	FC, IF, FuncS	scFv-(D-Arg)₉
IAB-B066(G)	Recombinant Anti-human KDR Intrabody [+36 GFP]	CO-IP, FuncS	scFv-(+36GFP)
IAB-B066(T)	Recombinant Anti-human KDR Intrabody [Tat]	IF, ELISA, FuncS	scFv-Tat

Humanized Antibody

CAT	Product Name	Application	Type
TAB-202	Humanized Anti-KDR Recombinant Antibody (clone Alacizumab); di - Fab' Fragment	IF, IP, Neut, FuncS, ELISA, FC, ICC	Humanized (from mouse) di - Fab'
TAB-411CQ	Anti-Human KDR Recombinant Antibody (HLX06)	ELISA	Humanized antibody
TAB-411CQ-S(P)	Anti-Human KDR Recombinant Antibody scFv Fragment (HLX06)	ELISA	Humanized antibody
TAB-411CQ-F(E)	Anti-Human KDR Recombinant Antibody Fab Fragment (HLX06)	ELISA	Humanized antibody

Immunotoxin

CAT	Product Name	Application	Type
AGTO-G047E	Anti-KDR immunotoxin (IgG1)-PE	Cytotoxicity assay, Function study

Fab Fragment Antibody

CAT	Product Name	Application	Type
PFBC-204	Human Anti-KDR Recombinant Antibody (clone mAb6.64); Fab Fragment	Neut, Block	Chimeric (mouse/human) Fab
HPAB-0097-YC-F(E)	Rabbit Anti-KDR Recombinant Antibody; Fab Fragment (HPAB-0097-YC-F(E))	ELISA, FuncS	Rabbit Fab
HPAB-0098-YC-F(E)	Rabbit Anti-KDR Recombinant Antibody; Fab Fragment (HPAB-0098-YC-F(E))	ELISA, FuncS	Rabbit Fab
HPAB-0099-YC-F(E)	Rabbit Anti-KDR Recombinant Antibody; Fab Fragment (HPAB-0099-YC-F(E))	ELISA, FuncS	Rabbit Fab
HPAB-0141-WJ-F(E)	Human Anti-KDR Recombinant Antibody (clone 2G1C12); Fab Fragment	ELISA	Human Fab

Mouse Antibody

CAT	Product Name	Application	Type
TAB-326CQ	Rat Anti-Kdr Recombinant Antibody (TAB-326CQ)	ELISA, IHC	Rat IgG
TAB-331CQ	Anti-Human KDR Recombinant Antibody (6.64)	IHC, ELISA	Mouse IgG1
TAB-332CQ	Anti-Human KDR Recombinant Antibody (4.13)	ELISA, FC, IHC
TAB-326CQ-S(P)	Rat Anti-Kdr Recombinant Antibody; scFv Fragment (TAB-326CQ-S(P))	ELISA, FC, WB	Rat scFv
TAB-331CQ-S(P)	Anti-Human KDR Recombinant Antibody scFv Fragment (6.64)	ELISA, FC, IHC

Human Antibody

CAT	Product Name	Application	Type
TAB-322CQ-F(E)	Anti-Human KDR Recombinant Antibody Fab Fragment (AK404R)	ELISA, WB	Human antibody
TAB-325CQ-F(E)	Human Anti-KDR Recombinant Antibody; Fab Fragment (TAB-325CQ-F(E))	ELISA, FC	Human Fab
TAB-329CQ-F(E)	Human Anti-KDR Recombinant Antibody; Fab Fragment (TAB-329CQ-F(E))	ELISA, WB, Neut	Human Fab
TAB-330CQ-F(E)	Mouse Anti-KDR Recombinant Antibody; Fab Fragment (TAB-330CQ-F(E))	ELISA, WB, Neut	Mouse Fab
TAB-333CQ-F(E)	Human Anti-KDR Recombinant Antibody; Fab Fragment (TAB-333CQ-F(E))	ELISA, FC	Human Fab

Chicken IgY Antibody

CAT	Product Name	Application	Type
BRD-0624MZ	Chicken Anti-VEGFR-2 Polyclonal IgY	IHC, WB	Chicken antibody
BRD-0709MZ	Chicken Anti-KDR Polyclonal IgY	WB	Chicken antibody

Neutralizing Antibody

CAT	Product Name	Application	Type
NEUT-1619CQ	Recombinant Mouse Anti-KDR Antibody (23B31)	WB, IP, FC, Neut
NEUT-1620CQ	Recombinant Rat Anti-Kdr Antibody (CBL840)	ELISA(Cap), Neut	IgG2a
NEUT-1621CQ	Recombinant Rat Anti-Kdr Antibody (CBL880)	Neut, WB	IgG2
NEUT-1622CQ	Recombinant Mouse Anti-KDR Antibody (6B11)	WB, Neut	IgG1
NEUT-1623CQ	Recombinant Mouse Anti-KDR Antibody (CBL505)	FC, CyTOF, Neut	IgG1

Rabbit Monoclonal Antibody

CAT	Product Name	Application	Type
MOR-1927	Hi-Affi™ Recombinant Rabbit Anti-KDR Monoclonal Antibody (DS1927AB)	IHC-P	IgG

Recombinant Antibody

CAT	Product Name	Application	Type
MOB-032CQ	Mouse Anti-KDR Antibody	WB, ELISA Capture	Mouse IgG1
MOB-033CQ	Goat Anti-KDR Polyclonal Antibody	WB, ELISA(Det)	Goat IgG
MRO-1580-CN	Recombinant Rabbit Anti-KDR Monoclonal Antibody (SU03-42)	WB, IF, IHC, IP	Rabbit IgG
HPAB-0251-FY	Human Anti-KDR Recombinant Antibody (clone 043HAb-1)	ELISA	Human IgG1
HPAB-0252-FY	Human Anti-KDR Recombinant Antibody (clone 043HAb-2)	ELISA	Human IgG1

ADCC Enhanced Antibody

CAT	Product Name	Application	Type
AFC-TAB-079	Afuco™ Anti-KDR ADCC Recombinant Antibody (Ramucirumab), ADCC Enhanced	IP, IF, FuncS, FC, Neut, ELISA	ADCC enhanced antibody

Single-domain Antibody

CAT	Product Name	Application	Type
HPAB-0298-YJ-VHH	Recombinant Human Anti-KDR Nano Antibody (NTV1)	Inhib	Human VHH

scFv Fragment Antibody

CAT	Product Name	Application	Type
HPAB-1288-FY-F(E)	Mouse Anti-KDR Recombinant Antibody; Fab Fragment (HPAB-1288-FY-F(E))	ELISA, FC, Inhib	Mouse Fab
HPAB-1289-FY-F(E)	Mouse Anti-KDR Recombinant Antibody; Fab Fragment (HPAB-1289-FY-F(E))	ELISA, FC, Inhib	Mouse Fab
HPAB-1290-FY-F(E)	Mouse Anti-KDR Recombinant Antibody; Fab Fragment (HPAB-1290-FY-F(E))	ELISA, FC, Inhib	Mouse Fab
HPAB-0502-YJ-S(P)	Human Anti-KDR Recombinant Antibody (clone 1); scFv Fragment	ELISA, FC	Human scFv
HPAB-0503-YJ-S(P)	Human Anti-KDR Recombinant Antibody (clone 6); scFv Fragment	ELISA, FC	Human scFv

MHC Tetramer for Cancer

CAT	Product Name	Application	Type
MHC-YF304	A*24:02/Human VEGFR (SYGVLLWEI) MHC Monomer	MHC Multimer
MHC-YF772	H-2Db/Human VEGFR2/KDR fragment 1 (FSNSTNDILI) MHC Pentamer	FCM

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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