Recombinant Human Antibody (65C6) is capable of binding to IAV HA, expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-IAV HA mAb and CH1-3 region of human IgG1 and a light chain (LC) encoding VL from anti-IAV HA mAb and CL of human kappa light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition.
Figure 1 Bound antibodies 65C6 and 100F4 are internalized and block low-pH-induced fusion.
(C) Blockage of low-pH-triggered, wild-type H5 HA-mediated fusion by antibodies 65C6 and 100F4 but not PG16 control. Mean and standard deviation of fusion percentage in each image is shown below. (D) Blockage of low-pH-triggered, escape A of H5 HA-mediated fusion by antibody 65C6 but not by antibody 100F4 and PG16 control.
Qian, M., Hu, H., Zuo, T., Wang, G., Zhang, L., & Zhou, P. (2013). Unraveling of a neutralization mechanism by two human antibodies against conserved epitopes in the globular head of H5 hemagglutinin. Journal of virology, 87(6), 3571-3577.
Figure 2 Neutralization activity against H5N1 pseudotype A/Shenzhen/406H/06 by indicated concentrations of antibodies 65C6, 100F4, AVIg03, F10, and PG16. The neutralization activity was calculated as follows: relative luciferase activity (RLA) of pseudotype with a given concentration of an antibody/RLA of pseudotype alone without antibodies.
Qian, M., Hu, H., Zuo, T., Wang, G., Zhang, L., & Zhou, P. (2013). Unraveling of a neutralization mechanism by two human antibodies against conserved epitopes in the globular head of H5 hemagglutinin. Journal of virology, 87(6), 3571-3577.
Figure 3 (B) Effects of indicated concentrations of antibodies 65C6, 100F4, AVIg03, F10, and PG16 on binding of H5N1 pseudotype. A/Shenzhen/406H/06 to MDCK cells compared to binding of pseudotype alone (without antibodies). (C) Effects of indicated concentrations of antibodies 65C6, 100F4, AVIg03, F10, and PG16 on postattachment entry of H5N1 pseudotype A/Shenzhen/406H/06 into MDCK cells compared to entry of pseudotype alone (without antibodies).
Qian, M., Hu, H., Zuo, T., Wang, G., Zhang, L., & Zhou, P. (2013). Unraveling of a neutralization mechanism by two human antibodies against conserved epitopes in the globular head of H5 hemagglutinin. Journal of virology, 87(6), 3571-3577.
Figure 4 (D) Effects of antibodies 65C6, 100F4, AVIg03, F10, and PG16 on pH 5.0-triggered, HA-mediated cell-cell fusion among influenza H5 HA-transduced HeLa cells. (E) Mean and standard deviation of fusion percentages in each image in panel D.
Qian, M., Hu, H., Zuo, T., Wang, G., Zhang, L., & Zhou, P. (2013). Unraveling of a neutralization mechanism by two human antibodies against conserved epitopes in the globular head of H5 hemagglutinin. Journal of virology, 87(6), 3571-3577.
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• Increased sensitivity
• Confirmed specificity
• High repeatability
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• Animal-free production
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CAT | Product Name | Application | Type |
---|---|---|---|
PFBL-203 | Recombinant Human Anti-IAV HA Antibody Fab Fragment (3.1) | WB, ELISA, FuncS | Fab |
PFBL-204 | Recombinant Human Anti-IAV HA Antibody Fab Fragment (39.29) | Neut, FuncS | Fab |
PFBL-205 | Recombinant Human Anti-IAV HA Antibody Fab Fragment (1957) | WB, Neut, FuncS | Fab |
PFBL-206 | Recombinant Human Anti-IAV HA Antibody Fab Fragment (1F1) | WB, ELISA, FuncS | Fab |
PFBL-207 | Recombinant Human Anti-IAV HA Antibody Fab Fragment (5J8) | WB, ELISA, FuncS | Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
PABL-482 | Recombinant Human Anti-H1N1 HA Antibody (CH65) | FuncS, Neut, WB | IgG |
PABL-483 | Recombinant Human Anti-H1N1 HA Antibody (CH67) | IF, FC | IgG |
PABL-484 | Recombinant Human Anti-H1N1 HA Antibody (I2) | Neut | IgG |
PABL-485 | Recombinant Mouse Anti-H1N1 HA Antibody | WB, ELISA, FuncS | IgG |
PABL-487 | Recombinant Human Anti-H2N2 HA Antibody (2G1 ) | FuncS | IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
PFBC-160 | Human Anti-HA Recombinant Antibody; Fab Fragment (PFBC-160) | Neut, ELISA, FC | Human Fab |
FAMAB-0254-YC-S(P) | Recombinant Mouse Anti-HA Antibody scFv Fragment (H153-70A12) | ELISA | Mouse scFv |
FAMAB-0277-YC-S(P) | Recombinant Mouse Anti-HA Antibody scFv Fragment (T1-107) | ELISA | Mouse scFv |
HPAB-0373-YJ-S(P) | Mouse Anti-HA Recombinant Antibody; scFv Fragment (HPAB-0373-YJ-S(P)) | ELISA, Neut, IF, FuncS | Mouse scFv |
HPAB-S0058-YC-S(P) | Mouse Anti-HA Recombinant Antibody (clone HC19); scFv Fragment | Neut | Mouse scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-274CT | Anti-IAV HA Recombinant Antibody (HC31) | ELISA, Funcs, IP, Neut | |
MRO-275CT | Anti-IAV HA Recombinant Antibody (HC100) | Funcs, IP, Neut | |
PABX-068-F (E) | Recombinant Mouse Anti-Hemagglutinin(HA) Antibody Fab Fragment (1F1) | WB, ELISA, FuncS | Fab |
PABX-069-F (E) | Recombinant Mouse Anti-Hemagglutinin(HA) Antibody Fab Fragment (S139/1 ) | ELISA, Neut, FuncS | Fab |
PABX-070-F (E) | Recombinant Mouse Anti-HA1 Antibody Fab Fragment (Fab17/9) | WB, ELISA, Neut, FuncS | Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-262CT-S(P) | Anti-IAV HA Recombinant Antibody scFv Fragment (D3-4) | WB, FC, IP | Human antibody |
MRO-263CT-S(P) | Anti-IAV HA Recombinant Antibody scFv Fragment (D4-2) | WB, FC, IP | Human antibody |
MRO-264CT-S(P) | Anti-IAV HA Recombinant Antibody scFv Fragment (D4-3) | WB, FC, IP | Human antibody |
MRO-265CT-S(P) | Anti-IAV HA Recombinant Antibody scFv Fragment (D4-4) | WB, FC, IP | Human antibody |
MRO-273CT-F(E) | Anti-IAV HA Recombinant Antibody Fab Fragment (IgG 316) | WB, Neut | Human antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
PABX-070-S (P) | Recombinant Mouse Anti-HA1 Antibody scFv Fragment (Fab17/9) | WB, ELISA, Neut, FuncS | scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-4209 | Hi-Affi™ Recombinant Rabbit Anti-HA Monoclonal Antibody (SI287DS) | ELISA, ICC/IF, IF, FC | IgG |
MOR-4210 | Hi-Affi™ Recombinant Rabbit Anti-HA Monoclonal Antibody (SI288DS) | ELISA, ICC/IF, IF, FC | IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-1169-FY | Llama Anti-HA Recombinant Single Domain Antibody (HPAB-1169-FY) | Neut | Llama VHH |
HPAB-1170-FY | Llama Anti-HA Recombinant Single Domain Antibody (HPAB-1170-FY) | Neut | Llama VHH |
HPAB-1171-FY | Llama Anti-HA Recombinant Single Domain Antibody (HPAB-1171-FY) | Neut | Llama VHH |
HPAB-1172-FY | Llama Anti-HA Recombinant Single Domain Antibody (HPAB-1172-FY) | Neut | Llama VHH |
HPAB-1173-FY | Llama Anti-HA Recombinant Single Domain Antibody (HPAB-1173-FY) | Neut | Llama VHH |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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