Recombinant Anti-IAV PB2 Intrabody [(D-Arg)9] (CAT#: IAB-B068(A))

Recombinant anti-IAV PB2 intrabody linked to (D-Arg)9 works within cells to bind IAV PB2, expressed in CHO cells. The anti-PB2 intrabody is potentially able to interfere with the effective nuclear transporscFv-HIV-Tation of PB2 protein, resulting in the observed resistance to influenza A virus infection in vitro.


Specific Inquiry
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  • Datasheet
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Specifications

  • Immunogen
  • IAV influenza A virus polymerase basic 2
  • Host Species
  • human
  • Type
  • scFv-(D-Arg)9
  • Cell Penetrating Peptide
  • (D-Arg)9
    It has been proven that polyarginine peptides composed of nine arginine amino acids (Arg-9) are able to translocate across cells very efficiently. This raises the question if molecular dynamics simulations would show a similar pathway for this highly hydrophilic and charged peptide as predicted for the Tat peptide. The simplicity of Arg-9 over other CPPs also helps isolate the role of the Arg sidechain on the translocation without the effect of other sidechains. Therefore, in this work we study computationally the translocation of Arg-9 through a lipid bilayer and show that the translocation mechanism is the same as for the Tat peptide.
  • Species Reactivity
  • IAV
  • Applications
  • Can be useful in applications such as: Western blot; Immunocytochemistry; Neutralization; Functional studies

Product Property

  • Purity
  • 95% by HPLC
  • Storage
  • ≥1 year at -20°C. If the reconstituted antibody cannot be used within two weeks, it should be aliquoted into smaller vials and stored at -20°C

Target

  • Alternative Names
  • IAV PB2; influenza A virus polymerase basic 2

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

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See other products for "IAV PB2"

Intrabody

CAT Product Name Application Type
IAB-B068(G) Recombinant Anti-IAV PB2 Intrabody [+36 GFP] PCA, Neut, FuncS scFv-(+36GFP)
IAB-B068(T) Recombinant Anti-IAV PB2 Intrabody [Tat] WB, Neut, FuncS scFv-Tat

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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