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Anti-IAV PB2 Intrabody [Tat] (IAB-B068(T))

Recombinant anti-IAV PB2 intrabody in fusion with HIV Tat works within cells to bind IAV PB2, expressed in CHO cells. The anti-PB2 intrabody is potentially able to interfere with the effective nuclear transporscFv-HIV-Tation of PB2 protein, resulting in the observed resistance to influenza A virus infection in vitro.      

Specifications
Immunogen
IAV influenza A virus polymerase basic 2
Host
human
Type
scFv-Tat
Cell Penetrating Peptide
TAT
TAT was able to deliver different proteins, such as horseradish peroxidase and RNase A across cell membrane into the cytoplasm in different cell lines in vitro. The size range of proteins with effective delivery is from 30kDa to 120-150kDa. In one study, TAT-fused proteins are rapidly internalized by lipid raft−dependent macropinocytosis using a transducible TAT−Cre recombinase reporter assay on live cells. In another study, a TAT-fused protein was delivered into mitochondria of breast cancer cells and decreased the survival of breast cancer cells, which showed capability of TAT-fusion proteins to modulate mitochondrial function and cell survival. However, very few in vivo studies have succeeded. In one study, in vivo delivery of TAT- or penetratin-crosslinked Fab fragments yielded varied organ distributions and an overall increase in organ retention, which showed tissue localization.
Species Reactivity
IAV
Applications
Antibody assay: Western blot; Neutralization; Functional studies
Target
Alternative Names
IAV PB2; influenza A virus polymerase basic 2

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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