Recombinant monoclonal antibody to IFNAR-1. This antibody intended for the prophylaxis and treatment of Inflammatory Bowel Diseas.
Figure 1 Inhibition of tyrosine phosphorylation of the components of the signaling pathway in CD34⁺ cells following IFNα activation inthe presence of the 64G12 mAb.
Highly purified (< 95% purity) freshly isolated (day 0) CD34⁺ cells (5 ×10⁵ per lane) were treated (+) or not(−) with anti-IFNAR1 mAb 64G12 (100μg/ml) followed by the addition of IFNα2 (1000 IU/ml) for 15 min at 37°C.
Giron-Michel, J., Weill, D., Bailly, G., Legras, S., Nardeux, P. C., Azzarone, B., ... & Eid, P. (2002). Direct signal transduction via functional interferon-αβ receptors in CD34+ hematopoietic stem cells. Leukemia, 16(6), 1135.
Figure 2 Effect of IFNα2 on nuclear translocation of STAT2 and IRF1 in CD34⁺ cells.
Freshly isolated (day 0), and highly purified (>95%) CD34⁺ cells were fixed, permeabilized, and stained with anti-STAT2, or anti-IRF-1 (green spots) and propidium iodide (for nucleal staining, redspots). Yellow spots indicate nuclear localization. CD34⁺ cells 30min after treatment with neutralizing anti-IFNARI antibodies followed by 30 min treatment with IFNα2.
Giron-Michel, J., Weill, D., Bailly, G., Legras, S., Nardeux, P. C., Azzarone, B., ... & Eid, P. (2002). Direct signal transduction via functional interferon-αβ receptors in CD34+ hematopoietic stem cells. Leukemia, 16(6), 1135.
Figure 3 Effect of IFNα on colony formation by CD34⁺ cells inthe absence or presence of the anti-IFNα receptor mAb 64G12.
Four hundred purified CD34⁺ cells (purity 80 ±5%) were incubated in thepresence of 1 μg/ml of the 64G12 mAb for 1 h at 37 °C then seeded in the presence of IFNα(1000 IU/ml) or IFNγ (1000 IU/ml) and plated in methylcellulose medium. The data presented are representative from a total of three independent experiments. Colonies werecounted on day 14 to determine the number of CFU-GM and BFU-E. The data are presented as the number of coloniesformed per 10³ cells and expressed as mean ±s.d. of triplicate plates.
Giron-Michel, J., Weill, D., Bailly, G., Legras, S., Nardeux, P. C., Azzarone, B., ... & Eid, P. (2002). Direct signal transduction via functional interferon-αβ receptors in CD34+ hematopoietic stem cells. Leukemia, 16(6), 1135.
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CAT | Product Name | Application | Type |
---|---|---|---|
MOB-1305z | Mouse Anti-IFNAR1 Recombinant Antibody (MOB-1305z) | ELISA, WB, IP, IF, IHC, FC | Mouse IgG1, κ |
HPAB-0203CQ | Human Anti-IFNAR1 Recombinant Antibody (clone H3K1) | ELISA, FC, Inhib | Humanized IgG1 |
HPAB-0204CQ | Human Anti-IFNAR1 Recombinant Antibody (HPAB-0204CQ) | ELISA, WB, FC, Inhib, FuncS | Human IgG1 |
MRO-0811-CN | Mouse Anti-IFNAR1 Recombinant Antibody (clone A5-A3) | WB, IHC, IF | Mouse IgG1 |
MRO-0812-CN | Rabbit Anti-IFNAR1 Recombinant Antibody (clone CBACN-299) | WB, IP, IHC, FC | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
MOB-1305z-S(P) | Recombinant Anti-Human IFNAR1 Antibody scFv Fragment | RIA, ELISA, FuncS | scFv |
PSBL-228 | Human Anti-IFNAR1 Recombinant Antibody (clone MEDI546); scFv Fragment | WB, ELISA, FuncS | Human scFv |
HPAB-0203CQ-S(P) | Human Anti-IFNAR1 Recombinant Antibody (clone H3K1); scFv Fragment | ELISA, FC, Inhib | Humanized scFv |
HPAB-J0126-YC-S(P) | Human Anti-IFNAR1 Recombinant Antibody (clone ch64G12); scFv Fragment | ELISA, FC | Mouse scFv |
HPAB-J0127-YC-S(P) | Human Anti-IFNAR1 Recombinant Antibody (clone H2K1); scFv Fragment | ELISA, FC | Humanized (mouse/human) scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-131CT | Anti-Human IFNAR-1 Recombinant Antibody (CPI-1697) | ELISA, FC | Humanized antibody |
TAB-131CT-S(P) | Anti-Human IFNAR-1 Recombinant Antibody scFv Fragment (CPI-1697) | ELISA, FC | Humanized antibody |
TAB-131CT-F(E) | Anti-Human IFNAR-1 Recombinant Antibody Fab Fragment (CPI-1697) | ELISA, FC | Humanized antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-130CT-S(P) | Anti-Human IFNAR-1 Recombinant Antibody scFv Fragment (64G12) | ELISA, FC | |
TAB-130CT-F(E) | Anti-Human IFNAR-1 Recombinant Antibody Fab Fragment (64G12) | ELISA, FC |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-976CQ | Mouse Anti-Ifnar1 Recombinant Antibody (clone MAR1-5A3) | FC, Neut, IP, WB, B | Mouse IgG1 |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-1740 | Rabbit Anti-IFNAR1 Recombinant Antibody (clone DS1740AB) | WB, FC, IP | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
AFC-TAB-722 | Afuco™ Anti-IFNAR ADCC Recombinant Antibody (Anifrolumab), ADCC Enhanced | FuncS, IF, Neut, ELISA, FC, IP | ADCC enhanced antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-M0362-YC-F(E) | Human Anti-IFNAR1 Recombinant Antibody (clone H15D10+L8C3); Fab Fragment | ELISA | Human Fab |
HPAB-M0363-YC-F(E) | Human Anti-IFNAR1 Recombinant Antibody (clone H19B7+L8C3); Fab Fragment | ELISA | Human Fab |
HPAB-M0364-YC-F(E) | Human Anti-IFNAR1 Recombinant Antibody (clone H15D10+L16C11); Fab Fragment | ELISA | Human Fab |
HPAB-M0365-YC-F(E) | Human Anti-IFNAR1 Recombinant Antibody (clone H19B7+L16C11); Fab Fragment | ELISA | Human Fab |
HPAB-J0126-YC-F(E) | Human Anti-IFNAR1 Recombinant Antibody (clone ch64G12); Fab Fragment | ELISA, FC | Chimeric (mouse/human) Fab |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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