Products

Anti-IL-18R1 or IL-18Rα (interleukin-18R1 or interleukin-18Rα) Therapeutic Antibody (2D11) (TAB-210CT)

Recombinant monoclonal antibody to interleukin-18Rα. This antibody intended for the prophylaxis and treatment of Chronic obstructive pulmonary disease (COPD).      

Specifications
Immunogen
DNA plasmid expressing both chains (alpha and beta) of human IL-18 receptor
Host
Mouse
Specificity
Human
Species Reactivity
Cynomolgus monkey
Clone
2D11
Applications
Used for immunoassay techniques such as: Flow Cytometry; Enzyme-linked Immunosorbent Assay; Ibhibition
Related Disease
Chronic obstructive pulmonary disease (COPD)
Target
Alternative Names
The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This receptor specifically binds interleukin 18 (IL18), and is essential for IL18 mediated signal transduction. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. This gene along with four other members of the interleukin 1 receptor family, including IL1R2, IL1R1, ILRL2 (IL-1Rrp2), and IL1RL1 (T1/ST2), form a gene cluster on chromosome 2q. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Entrez Gene ID
8809
UniProt ID
Q13478

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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