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Anti-IL-19 (interleukin-19) Therapeutic Antibody (1BB1) (TAB-212CT)

Monoclonal antibody 1BB1, specific to human IL-19, effectively inhibits breast cancer cell proliferation and breast tumor growth, and prolongs survival of mice bearing breast cancer.      

Specifications
Host
Mouse
Specificity
Human
Species Reactivity
Mouse
Clone
1BB1
Applications
Used for immunoassay techniques such as: Enzyme-linked Immunosorbent Assay; Western Blot
Related Disease
Breast Cancer
Target
Alternative Names
The protein encoded by this gene is a cytokine that belongs to the IL10 cytokine subfamily. This cytokine is found to be preferentially expressed in monocytes. It can bind the IL20 receptor complex and lead to the activation of the signal transducer and activator of transcription 3 (STAT3). A similar cytokine in mouse is reported to up-regulate the expression of IL6 and TNF-alpha and induce apoptosis, which suggests a role of this cytokine in inflammatory responses. Alternatively spliced transcript variants encoding the distinct isoforms have been described.
Entrez Gene ID
29949
UniProt ID
Q9UHD0

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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