Anti-Human IL-1R1 (Interleukin 1 receptor type 1) Therapeutic Single Domain Antibody (DOM4-130) (CAT#: TAB-216CT)

Recombinant single domain antibody to Interleukin 1 receptor type 1. DOM4-130 is a single domain antibody intended for the prophylaxis and treatment of lung inflammation or a respiratory disease.


Specific Inquiry
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  • Purity:
  • Published Data
  • Gene Expression
  • Datasheet
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  • COA
Inhib

Figure 1 The results of in vitro assays in which dAbs were tested for the ability to inhibit IL-1-induced IL-8 release from cultured MRC-5 cells.

Figure 1 The results of in vitro assays in which dAbs were tested for the ability to inhibit IL-1-induced IL-8 release from cultured MRC-5 cells.

A typical dose-response curve for an anti-IL-1R1 dAb referred to as DOM4-130 in such a cell assay. The ND50 of DOM4-130 in the assay was approximately 500-1000 nM.


Specifications

  • Host Species
  • Llama
  • Derivation
  • 4G-K2 library of VK dAbs
  • Type
  • Single domain antibody
  • Specificity
  • Human
  • Species Reactivity
  • Human
  • Clone
  • DOM4-130
  • Applications
  • Inhibition
  • Related Disease
  • Lung inflammation, Respiratory disease

Applications

  • Application Notes
  • The antibody was validated for Inhibition. For details, refer to Published Data.

Target

  • Alternative Names
  • This gene encodes a cytokine receptor that belongs to the interleukin-1 receptor family. The encoded protein is a receptor for interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor antagonist. It is an important mediator involved in many cytokine-induced immune and inflammatory responses. This gene is located in a cluster of related cytokine receptor genes on chromosome 2q12.

Related Resources

  • Related Diseases

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "IL1R1"

Immunotoxin

CAT Product Name Application Type
AGTO-L026P anti-IL1R1 immunotoxin TP3 (IgG)-PAP Cytotoxicity assay, Functional assay

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-392CL Afuco™ Anti-IL1R1 Recombinant Antibody (AFC-392CL), ADCC Enhanced ELISA, WB Human IgG1

Single-domain Antibody

Neutralizing Antibody

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-1799 Rabbit Anti-IL1R1 Recombinant Antibody (clone DS1799AB) WB, FC, IP Rabbit IgG

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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