Human Anti-IL1B Recombinant Antibody (clone B1) (CAT#: HPAB-0030-YC)
lnterleukin-1 beta (IL-1 B), also known as catabolin, is a cytokine protein. IL-1 B is a member of the interleukin 1 family of cytokines and is also described as interleukin 1, beta; IL-1 b; IL-1 β; IL1 -BETA; IL1 F2. Anti-IL-1 B antagonist molecules, in particular anti-IL-1 B antagonist molecules, which have high binding affinity to IL-1 B. It can be used as therapeutic agents to treat diseases, in particular respiratory diseases in humans.
Specific Inquiry
ELISA
Figure 1 IL1B inhibits gastrin expression in AGS cells.
Treatment of AGS cells with increasing amount of recombinant IL1B protein for 2 h caused gradual decrease in endogenous gastrin as measured by ELISA.
Chakravorty, M., De, D. D., Choudhury, A., & Roychoudhury, S. (2009). IL1B promoter polymorphism regulates the expression of gastric acid stimulating hormone gastrin. The international journal of biochemistry & cell biology, 41(7), 1502-1510.
WB
Figure 2 Time course analysis of IKβ degradation in IL1B treated AGS cells.
One representative of at least three independent experiments with similar results is shown.
Chakravorty, M., De, D. D., Choudhury, A., & Roychoudhury, S. (2009). IL1B promoter polymorphism regulates the expression of gastric acid stimulating hormone gastrin. The international journal of biochemistry & cell biology, 41(7), 1502-1510.
Inhib
Figure 3 Release of IL1B mediated inhibition of gastrin expression by NFB inhibitor TPCK in AGS cells.
Cells were lysed and ELISA measured gastrin protein expression.
Chakravorty, M., De, D. D., Choudhury, A., & Roychoudhury, S. (2009). IL1B promoter polymorphism regulates the expression of gastric acid stimulating hormone gastrin. The international journal of biochemistry & cell biology, 41(7), 1502-1510.
Specifications
- Immunogen
- Recombinant human IL-1 B
- Host Species
- Human
- Derivation
- Humanized
- Type
- Humanized IgG1, κ
- Specificity
- Human IL1B
- Species Reactivity
- Human, Mouse, Cynomolgus
- Clone
- B1
- Applications
- Inhib, WB, ELISA
- Related Disease
- Respiratory disease
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- The IL1B antibody has been reported in applications of Enzyme-linked Immunosorbent Assay, Western Blot, Inhibition.
Target
Related Resources
Rheumatoid Arthritis
Maturity Onset Diabetes of the Young
TNF Signaling Pathway
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "Clone B1"
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scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBL-239 | Human Anti-IL1B Recombinant Antibody (clone YC129); scFv Fragment | WB, IHC, FuncS | Human scFv |
| HPAB-0729-FY-F(E) | Mouse Anti-IL1B Recombinant Antibody; Fab Fragment (HPAB-0729-FY-F(E)) | ELISA, Neut | Mouse Fab |
| HPAB-0730-FY-F(E) | Mouse Anti-IL1B Recombinant Antibody; Fab Fragment (HPAB-0730-FY-F(E)) | ELISA, Neut | Mouse Fab |
| HPAB-1266WJ-S(P) | Mouse Anti-IL1B Recombinant Antibody; scFv Fragment (HPAB-1266WJ-S(P)) | ELISA, WB | Mouse scFv |
| HPAB-1861-FY-F(E) | Human Anti-IL1B Recombinant Antibody (clone Hu007); scFv Fragment | Neut | Humanized scFv |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBL-239 | Human Anti-IL1B Recombinant Antibody (clone YC129); Fab Fragment | WB, IHC, FuncS | Human Fab |
| PFBC-082 | Mouse Anti-IL1B Recombinant Antibody (clone YC128); Fab Fragment | WB, ELISA | Mouse Fab |
| HPAB-0030-YC-F(E) | Human Anti-IL1B Recombinant Antibody (clone B1); Fab Fragment | FuncS | Humanized Fab |
| HPAB-0031-YC-F(E) | Human Anti-IL1B Recombinant Antibody (clone ABT2-76); Fab Fragment | ELISA, Neut | Human Fab |
| HPAB-0032-YC-F(E) | Human Anti-IL1B Recombinant Antibody (clone AAL160); Fab Fragment | Neut, Block | Human Fab |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-230CT | Mouse Anti-IL1B Recombinant Antibody (TAB-230CT) | ELISA | Mouse IgG |
| TAB-231CT | Anti-Human IL-1β (Interleukin 1 beta) Recombinant Antibody (47F11) | Inhibition | |
| TAB-234CT | Rabbit Anti-IL1B Recombinant Antibody (TAB-234CT) | FC, ELISA, Neut | Rabbit IgG |
| TAB-235CT | Anti-Human IL-1β (Interleukin 1 beta) Recombinant Antibody (SK48-E26) | ELISA, Neut | |
| TAB-542LC | Anti-human IL1B Recombinant Antibody (SK48-E26) (TAB-542LC) | ELISA, Neut |
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-233CT | Human Anti-IL1B Recombinant Antibody (TAB-233CT) | IF | Humanized IgG |
| TAB-233CT-S(P) | Human Anti-IL1B Recombinant Antibody; scFv Fragment (TAB-233CT-S(P)) | ELISA | Humanized scFv |
| TAB-236CT-S(P) | Anti-Human IL-1β (Interleukin 1 beta) Recombinant Antibody scFv Fragment (huSK48-E26) | ELISA, Neut | Humanized antibody |
| TAB-233CT-F(E) | Human Anti-IL1B Recombinant Antibody; Fab Fragment (TAB-233CT-F(E)) | ELISA | Humanized Fab |
| TAB-236CT-F(E) | Anti-Human IL-1β (Interleukin 1 beta) Recombinant Antibody Fab Fragment (huSK48-E26) | ELISA, Neut | Humanized antibody |
Chimeric Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-232CT-S(P) | Anti-Human IL-1β (Interleukin 1 beta) Recombinant Antibody scFv Fragment (ch47F11) | Inhibition | Chimeric antibody (mouse/human) |
| TAB-237CT-S(P) | Anti-Human IL-1β (Interleukin 1 beta) Recombinant Antibody scFv Fragment (chSK48-E26) | ELISA, Neut | Chimeric antibody (mouse/human) |
| TAB-232CT-F(E) | Anti-Human IL-1β (Interleukin 1 beta) Recombinant Antibody Fab Fragment (ch47F11) | Inhibition | Chimeric antibody (mouse/human) |
| TAB-237CT-F(E) | Anti-Human IL-1β (Interleukin 1 beta) Recombinant Antibody Fab Fragment (chSK48-E26) | ELISA, Neut | Chimeric antibody (mouse/human) |
| TAB-543LC-F(E) | Anti-human IL1B Fab Fragment, Chimeric | ELISA | Chimeric antibody (mouse/human) |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-550LC-F(E) | Anti-human IL1B Fab Fragment (9.5.2) | ELISA | Human antibody |
| TAB-551LC-F(E) | Anti-human IL1B Fab Fragment (5.5.1) | ELISA | Human antibody |
| TAB-552LC-F(E) | Anti-human IL1B Fab Fragment (8.18.1) | ELISA | Human antibody |
| TAB-553LC-F(E) | Anti-human IL1B Fab Fragment (6.20.1) | ELISA | Human antibody |
| TAB-554LC-F(E) | Anti-human IL1B Fab Fragment (6.33.1) | ELISA | Human antibody |
Chicken IgY Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0282MZ | Chicken Anti-Interleukin-1β Polyclonal IgY | WB, Indirect ELISA | Chicken antibody |
Blocking Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1274CQ | Mouse Anti-IL1B Recombinant Antibody (clone B-A15) | Block, FC | Mouse IgG1 |
| NEUT-1285CQ | Mouse Anti-IL1B Recombinant Antibody (clone H1b-27) | ELISA, ELISPOT, Block | Mouse IgG2b, κ |
Neutralizing Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1282CQ | Mouse Anti-IL1B Recombinant Antibody (clone CRM56) | FC, ELISA, Neut | Mouse IgG1 |
| NEUT-1283CQ | Mouse Anti-IL1B Recombinant Antibody (clone 4H5) | Neut | Mouse IgG1 |
| NEUT-1284CQ | Mouse Anti-IL1B Recombinant Antibody (clone 7E3) | Neut | Mouse IgG1 |
| NEUT-1286CQ | Hamster Anti-Il1b Recombinant Antibody (clone B122) | WB, IP, Neut | Hamster IgG |
| NEUT-1287CQ | Rat Anti-Il1b Recombinant Antibody (clone CBL448) | ELISA, Neut | Rat IgG1 |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1798 | Rabbit Anti-IL1B Recombinant Antibody (clone DS1798AB) | WB | Rabbit IgG |
| MOR-4237 | Rabbit Anti-IL1B Recombinant Antibody (clone SI316DS) | ELISA | Rabbit IgG |
| MOR-4238 | Rabbit Anti-IL1B Recombinant Antibody (clone SI317DS) | ELISA | Rabbit IgG |
| MOR-4239 | Rabbit Anti-IL1B Recombinant Antibody (clone SI318DS) | ELISA | Rabbit IgG |
| MOR-4605 | Rabbit Anti-IL1B Recombinant Antibody (clone TH118DS) | WB | Rabbit IgG |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0031-YC | Human Anti-IL1B Recombinant Antibody (clone ABT2-76) | ELISA, Neut | Human IgG |
| HPAB-0032-YC | Human Anti-IL1B Recombinant Antibody (clone AAL160) | Neut, Block | Human IgG1, κ |
| HPAB-0916-WJ | Human Anti-IL1B Recombinant Antibody (HPAB-0916-WJ) | Neut | Humanized IgG |
| HPAB-0917-WJ | Human Anti-IL1B Recombinant Antibody (HPAB-0917-WJ) | WB, ELISA, Block | Humanized IgG |
| HPAB-0918-WJ | Human Anti-IL1B Recombinant Antibody (HPAB-0918-WJ) | ELISA | Humanized IgG |
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-021 | Afuco™ Anti-IL1B ADCC Recombinant Antibody (Canakinumab), ADCC Enhanced | ELISA, IP, FC, FuncS, Neut | ADCC enhanced antibody |
| AFC-TAB-161 | Afuco™ Anti-IL1B ADCC Recombinant Antibody (Gevokizumab), ADCC Enhanced | ELISA, FC, IP, FuncS, IF, Neut | ADCC enhanced antibody |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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