Products

anti-IL1R1 immunotoxin TP3 (IgG)-PAP (AGTO-L026P)

This immunotoxin was achieved by conjugating/fusing the Anti-IL1R1 monoclonal antibody to Pokeweed antiviral protein. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to osteosarcoma cells and the toxin enters cells by receptor-mediated endocytosis. Then PAP is introduced into the cytoplasm where it eventually causes cell death by inactivating ribosomes. It was designed for treatment of osteosarcoma.      

Specifications
Host
Mouse
Species Reactivity
Human
Clone
TP3
Molecule Class
IgG-PAP
Toxin Description
Pokeweed antiviral protein (PAP) is a type I ribosome inactivating protein isolated from the pokeweed plant, Phytolacca americana. The toxin is introduced into the cytoplasm where it eventually causes cell death by inactivating ribosomes.
Applications
This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
Related Disease
Osteosarcoma
Target
Alternative Names
IL1R1; interleukin 1 receptor, type I; P80; IL1R; IL1RA; CD121A; D2S1473; IL-1R-alpha
Entrez Gene ID
3554
UniProt ID
P14778

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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