Anti-Human IL23A Recombinant Antibody (BI 655066) (CAT#: TAB-420CL)

Recombinant Humanized monoclonal antibody expressed in CHO binding to Human IL23A. BI 655066 is a fully human IgG1 mAb specific for the IL-23 p19 subunit. IL-23 is associated with plaque psoriasis susceptibility and pathogenesis. BI 655066 was well tolerated and associated with rapid, substantial, and durable clinical improvement in patients with moderate-to-severe psoriasis, supporting a central role for IL-23 in psoriasis pathogenesis.


Specific Inquiry
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  • Purity:
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  • Published Data
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
FuncS

Figure 1 Pharmacokinetics of BI 655066 in cynomolgus monkeys follow ing a single 1 mg/kg intravenous (IM) or subcutaneous (SC) dose.

Figure 1 Pharmacokinetics of BI 655066 in cynomolgus monkeys follow ing a single 1 mg/kg intravenous (IM) or subcutaneous (SC) dose.

Serum concentrations were measured using an IL23-capture ELISA. Data are the mean ± SD of three monkeys per dose route. Bioavailability was estimated to be>70%, and the half-life (9-12 days) was similar after intrave nous or subcutaneous administration.

Singh, S., Kroe-Barrett, R. R., Canada, K. A., Zhu, X., Sepulveda, E., Wu, H., ... & Amodeo, L. M. (2015, July). Selective targeting of the IL23 pathway: generation and characterization of a novel high-affinity humanized anti-IL23A antibody. In MAbs (Vol. 7, No. 4, pp. 778-791). Taylor & Francis.


Specifications

  • Derivation
  • Human
  • Type
  • Antibody
  • Species Reactivity
  • Human
  • Applications
  • FuncS
  • Related Disease
  • Psoriasis

Product Property

  • Purity
  • 95% by HPLC
  • Storage
  • Store at -20°C. Avoid multiple freeze/thaw cycles.

Applications

  • Application Notes
  • This antibody has been tested for use in Functional Assay. It's recommended that the optimal antibody concentration, dilution, incubition time, etc. be carefully titrated in specific assays.

Target

  • Alternative Names
  • IL23A; interleukin 23, alpha subunit p19; P19; SGRF; IL-23; IL-23A; IL23P19; interleukin-23 subunit alpha; IL-23-A; IL-23p19; IL-23 subunit alpha; interleukin 23 p19 subunit; interleukin-23 subunit p19; JKA3 induced upon T-cell activation; interleukin-six

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "IL23A"

Single-domain Antibody

CAT Product Name Application Type
NAB-1953-VHH Recombinant Anti-human IL23A VHH Single Domain Antibody WB, IP, ICC, FC, FA Llama VHH
TAB-005LC-VHH Anti-human IL23A Recombinant Antibody (119A3) (TAB-005LC-VHH) ELISA Single domain antibody

Chimeric Antibody

CAT Product Name Application Type
TAB-607LC Anti-human IL23A Recombinant Antibody (E11E7Chimera) (TAB-607LC) ELISA, Neut, FuncS Chimeric antibody (rat/human)
TAB-607LC-S(P) Anti-human IL23A scFv Fragment (E11E7Chimera) ELISA Chimeric antibody (rat/human)
TAB-607LC-F(E) Anti-human IL23A Fab Fragment (E11E7Chimera) ELISA Chimeric antibody (rat/human)

Humanized Antibody

CAT Product Name Application Type
TAB-616LC Anti-human IL23A Recombinant Antibody (A3M0) (TAB-616LC) ELISA, FC, Inhib, FuncS Humanized antibody
TAB-617LC Anti-human IL23A Recombinant Antibody (A3M1) (TAB-617LC) ELISA, FC, Inhib Humanized antibody
TAB-618LC Anti-human IL23A Recombinant Antibody (A3N1) (TAB-618LC) ELISA, FC, Inhib Humanized antibody
TAB-605LC-S(P) Anti-human IL23A scFv Fragment (FM303) ELISA Humanized antibody
TAB-608LC-S(P) Anti-human IL23A scFv Fragment (21-4) ELISA Humanized antibody

Rabbit Monoclonal Antibody

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-875 Afuco™ Anti-IL23A ADCC Recombinant Antibody (Tildrakizumab), ADCC Enhanced Neut, ELISA, IF, IP, FuncS, FC ADCC enhanced antibody
AFC-TAB-620LC Afuco™ Anti-IL23A ADCC Recombinant Antibody (Risankizumab), ADCC Enhanced ELISA ADCC enhanced antibody
AFC-TAB-008ML Afuco™ Anti-IL23A ADCC Recombinant Antibody (Brazikumab), ADCC Enhanced ELISA, IHC, FC, IP, IF, Inhib ADCC enhanced antibody

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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