It is a humanized monoclonal antibody binding with interleukin 23 subunit alpha (IL23A), which is a key cytokine playing different roles in innate and adaptive immunity. The antibody was purified by affinity chromatography. It specifically binds to human IL-23 and can be potentially used in the research of rheumatoid arthritis.
Figure 1 The ability of tissue culture supernatant humanised mAbs to bind to human IL-23.
Figure 2 The ability of purified humanised mAbs to bind to human IL-23.
All samples were run in duplicate, and averages of each duplicate are shown. In addition, the assays using supernatant material were run twice using different preparations of tissue culture supernatant and a representative result is shown.
Figure 3 The ability of tissue culture supernatant humanised mAbs to inhibit binding of human IL-23 to human IL-23R.
Figure 4 The ability of purified humanised mAbs to inhibit binding of human IL-23 to human IL-23R.
Figure 5 The ability of purified humanised mAbs to inhibit binding of cynomolgus IL-23 to human IL-23R.
Figure 6 % inhibition of IL-22 production in this assay.
Figure 7 Anti-IL23 mAbs had no effect on the production of IL-12-driven IFNγ production from NK92 cells.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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CAT | Product Name | Application | Type |
---|---|---|---|
NAB-1953-VHH | Recombinant Anti-human IL23A VHH Single Domain Antibody | WB, IP, ICC, FC, FA | Llama VHH |
TAB-005LC-VHH | Anti-human IL23A Recombinant Antibody (119A3) (TAB-005LC-VHH) | ELISA | Single domain antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-875 | Anti-Human IL23 Recombinant Antibody (Tildrakizumab) | Neut, ELISA, IF, IP, FuncS, FC, ICC | IgG1 - kappa |
TAB-605LC | Anti-human IL23A Recombinant Antibody (FM303) (TAB-605LC) | ELISA | Humanized antibody |
TAB-608LC | Anti-human IL23A Recombinant Antibody (21-4) (TAB-608LC) | ELISA | Humanized antibody |
TAB-609LC | Anti-human IL23A Recombinant Antibody (8-22) (TAB-609LC) | ELISA | Humanized antibody |
TAB-610LC | Anti-human IL23A Recombinant Antibody (6-22) (TAB-610LC) | ELISA | Humanized antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-420CL | Anti-Human IL23A Recombinant Antibody (BI 655066) | FuncS | Antibody |
TAB-622LC | Human Anti-IL23A Recombinant Antibody (TAB-622LC) | ELISA | Human antibody |
TAB-613LC-S(P) | Anti-human IL23A scFv Fragment (ST883/885) | ELISA | Human antibody |
TAB-622LC-S(P) | Human Anti-IL23A Recombinant Antibody; scFv Fragment (TAB-622LC-S(P)) | ELISA | Human scFv |
TAB-008ML | Anti-Human IL23A Recombinant Antibody (Brazikumab) | ELISA, IHC, FC, IP, IF, Inhib | IgG2, λ |
CAT | Product Name | Application | Type |
---|---|---|---|
PABW-154 | Mouse Anti-IL23A Recombinant Antibody (clone CNTO4088) | WB | Mouse IgG |
HPAB-0517-CN | Mouse Anti-IL23A Recombinant Antibody (HPAB-0517-CN) | ELISA, FC | Mouse IgG |
HPAB-0518-CN | Human Anti-IL23A Recombinant Antibody (HPAB-0518-CN) | ELISA, FC | Humanized IgG |
HPAB-AP118-YC | Mouse Anti-IL23A Recombinant Antibody (HPAB-AP118-YC) | ELISA | Mouse IgG |
HPAB-AP119-YC | Mouse Anti-IL23A Recombinant Antibody (HPAB-AP119-YC) | ELISA | Mouse IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-606LC | Anti-human IL23A Recombinant Antibody (E11E7) (TAB-606LC) | ELISA, Neut | |
TAB-614LC | Anti-human IL23A Recombinant Antibody (8C9) (TAB-614LC) | ELISA, Inhib | |
TAB-621LC | Mouse Anti-IL23A Recombinant Antibody (TAB-621LC) | ELISA, WB, Neut | Mouse IgG |
TAB-606LC-S(P) | Anti-human IL23A scFv Fragment (E11E7) | ELISA | |
TAB-606LC-F(E) | Anti-human IL23A Fab Fragment (E11E7) | ELISA |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-607LC | Anti-human IL23A Recombinant Antibody (E11E7Chimera) (TAB-607LC) | ELISA, Neut, FuncS | Chimeric antibody (rat/human) |
TAB-607LC-S(P) | Anti-human IL23A scFv Fragment (E11E7Chimera) | ELISA | Chimeric antibody (rat/human) |
TAB-607LC-F(E) | Anti-human IL23A Fab Fragment (E11E7Chimera) | ELISA | Chimeric antibody (rat/human) |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-1335CQ | Mouse Anti-IL23A Recombinant Antibody (clone HNU2319) | FuncS, Neut | Mouse IgG1, κ |
NEUT-1336CQ | Rabbit Anti-IL23A Recombinant Antibody (VMC198) | WB, Neut | Rabbit IgG2b |
NEUT-1337CQ | Human Anti-IL23A Recombinant Antibody (clone CBL1018) | Neut | Human IgG1, κ |
NEUT-1338CQ | Mouse Anti-IL23A Recombinant Antibody (clone M066) | Neut | Mouse IgG1 |
NEUT-1339CQ | Mouse Anti-Il23a Recombinant Antibody (clone CBL1028) | Neut | Mouse IgG2b, κ |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-4335 | Rabbit Anti-IL23A Recombinant Antibody (clone SI424DS) | ELISA | Rabbit IgG |
MOR-4615 | Rabbit Anti-IL23A Recombinant Antibody (clone TH128DS) | WB | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0516-CN-S(P) | Human Anti-IL23A Recombinant Antibody; scFv Fragment (HPAB-0516-CN-S(P)) | ELISA, FC, Neut | Human scFv |
HPAB-0517-CN-S(P) | Mouse Anti-IL23A Recombinant Antibody; scFv Fragment (HPAB-0517-CN-S(P)) | ELISA, FC | Mouse scFv |
HPAB-0518-CN-S(P) | Human Anti-IL23A Recombinant Antibody; scFv Fragment (HPAB-0518-CN-S(P)) | ELISA, FC | Humanized scFv |
HPAB-0860-FY-F(E) | Mouse Anti-IL23A Recombinant Antibody; Fab Fragment (HPAB-0860-FY-F(E)) | Inhib | Mouse Fab |
HPAB-0861-FY-F(E) | Mouse Anti-IL23A Recombinant Antibody; Fab Fragment (HPAB-0861-FY-F(E)) | Inhib | Mouse Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
AFC-TAB-875 | Afuco™ Anti-IL23A ADCC Recombinant Antibody (Tildrakizumab), ADCC Enhanced | Neut, ELISA, IF, IP, FuncS, FC | ADCC enhanced antibody |
AFC-TAB-620LC | Afuco™ Anti-IL23A ADCC Recombinant Antibody (Risankizumab), ADCC Enhanced | ELISA | ADCC enhanced antibody |
AFC-TAB-008ML | Afuco™ Anti-IL23A ADCC Recombinant Antibody (Brazikumab), ADCC Enhanced | ELISA, IHC, FC, IP, IF, Inhib | ADCC enhanced antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0860-FY-S(P) | Mouse Anti-IL23A Recombinant Antibody; scFv Fragment (HPAB-0860-FY-S(P)) | Inhib | Mouse scFv |
HPAB-0861-FY-S(P) | Mouse Anti-IL23A Recombinant Antibody; scFv Fragment (HPAB-0861-FY-S(P)) | Inhib | Mouse scFv |
HPAB-0865-FY-S(P) | Mouse Anti-IL23A Recombinant Antibody; scFv Fragment (HPAB-0865-FY-S(P)) | ELISA | Mouse scFv |
HPAB-0866-FY-S(P) | Mouse Anti-IL23A Recombinant Antibody; scFv Fragment (HPAB-0866-FY-S(P)) | ELISA | Mouse scFv |
HPAB-0867-FY-S(P) | Mouse Anti-IL23A Recombinant Antibody; scFv Fragment (HPAB-0867-FY-S(P)) | ELISA | Mouse scFv |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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