Afuco™ Anti-IL31RA ADCC Recombinant Antibody, ADCC Enhanced (CAT#: AFC-410CL)
Anti-IL31RA ADCC Enhanced Antibody is an ADCC enhanced antibody produced by our Afuco™ platform. The anti-IL31RA antibodies having an effective neutralizing activity against IL31RA are useful as pharmaceuticals for treating or preventing inflammatory diseases.
Specific Inquiry
Subcellular Location and Protein Expression
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line U-251 MG
(Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm & vesicles.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/51532/if_selected.jpg
(Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm & vesicles.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/51532/if_selected.jpg
Figure 2 IHC staining of human lung
(Immunohistochemical staining of human lung shows moderate cytoplasmic positivity in macrophages.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/68114/160946_A_3_4_selected.jpg
(Immunohistochemical staining of human lung shows moderate cytoplasmic positivity in macrophages.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/68114/160946_A_3_4_selected.jpg
Figure 3 IF staining of human cell line PC-3
(Immunofluorescent staining of human cell line PC-3 shows localization to nucleoplasm & vesicles.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/51532/986_C6_2_red_green.jpg
(Immunofluorescent staining of human cell line PC-3 shows localization to nucleoplasm & vesicles.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/51532/986_C6_2_red_green.jpg
Figure 4 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm & vesicles.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/51532/832_C6_4_red_green.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm & vesicles.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/51532/832_C6_4_red_green.jpg
Figure 5 Lymph node
(Germinal center cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/68114/160946_A_9_8.jpg
(Germinal center cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/68114/160946_A_9_8.jpg
Figure 6 RNA cell line category: Cell line enhanced (GAMG, HBEC3-KT, HHSteC, hTERT-HME1, U-2 OS, U-87 MG)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000164509-IL31RA
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000164509-IL31RA
Specifications
- Host Species
- Humanized
- Derivation
- Humanized
- Type
- ADCC enhanced antibody
- Species Reactivity
- Human, Monkey
- Related Disease
- Inflammatory Diseases
Product Property
- Purity
- >95% as determined by analysis by SDS-PAGE
- Storage
- Store at 4°C for up to 3 months. For longer term storage aliquot into small volumes and store at -20°C.
Target
- Alternative Names
- CRL; GPL; CRL3; GLMR; GLM-R; PLCA2; hGLM-R; IL-31RA; PRO21384; zcytoR17
- Gene ID
- 133396
- UniProt ID
- Q8NI17
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "IL31RA"
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0972CT | Recombinant Mouse anti-Human IL31RA Monoclonal antibody (EML2192) | WB | |
| MOB-168CQ | Mouse Anti-IL31RA Recombinant Antibody (clone YC131) | ELISA, WB, IF, IP | Mouse IgG2a, κ |
| MOB-175CQ | Human Anti-IL31RA Recombinant Antibody (MOB-175CQ) | ELISA, FC | Chimeric (mouse/human) IgG |
| HPAB-1243-FY | Human Anti-IL31RA Recombinant Antibody (HPAB-1243-FY) | Neut | Human IgG |
| HPAB-J0130-YC | Mouse Anti-IL31RA Recombinant Antibody (HPAB-J0130-YC) | Inhib | Mouse IgG |
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-439CQ | Anti-Human IL31RA Recombinant Antibody (Nemolizumab) | ELISA, IHC, FC, IP, IF, FuncS | IgG2, κ |
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-439CQ | Afuco™ Anti-IL31RA ADCC Recombinant Antibody (Nemolizumab), ADCC Enhanced | ELISA, IHC, FC, IP, IF, FuncS | ADCC enhanced antibody |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-J0130-YC-S(P) | Mouse Anti-IL31RA Recombinant Antibody; scFv Fragment (HPAB-J0130-YC-S(P)) | ELISA, Inhib | Mouse scFv |
| HPAB-J0131-YC-S(P) | Mouse Anti-IL31RA Recombinant Antibody; scFv Fragment (HPAB-J0131-YC-S(P)) | ELISA, Inhib | Mouse scFv |
| HPAB-J0132-YC-S(P) | Mouse Anti-IL31RA Recombinant Antibody; scFv Fragment (HPAB-J0132-YC-S(P)) | ELISA, Inhib | Mouse scFv |
| HPAB-J0133-YC-S(P) | Mouse Anti-IL31RA Recombinant Antibody; scFv Fragment (HPAB-J0133-YC-S(P)) | ELISA, Inhib | Mouse scFv |
| HPAB-J0134-YC-S(P) | Human Anti-IL31RA Recombinant Antibody; scFv Fragment (HPAB-J0134-YC-S(P)) | ELISA, Inhib | Mouse scFv |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-J0130-YC-F(E) | Mouse Anti-IL31RA Recombinant Antibody; Fab Fragment (HPAB-J0130-YC-F(E)) | ELISA, Inhib | Mouse Fab |
| HPAB-J0131-YC-F(E) | Mouse Anti-IL31RA Recombinant Antibody; Fab Fragment (HPAB-J0131-YC-F(E)) | ELISA, Inhib | Mouse Fab |
| HPAB-J0132-YC-F(E) | Mouse Anti-IL31RA Recombinant Antibody; Fab Fragment (HPAB-J0132-YC-F(E)) | ELISA, Inhib | Mouse Fab |
| HPAB-J0133-YC-F(E) | Mouse Anti-IL31RA Recombinant Antibody; Fab Fragment (HPAB-J0133-YC-F(E)) | ELISA, Inhib | Mouse Fab |
| HPAB-J0134-YC-F(E) | Human Anti-IL31RA Recombinant Antibody; Fab Fragment (HPAB-J0134-YC-F(E)) | ELISA, Inhib | Chimeric (mouse/human) Fab |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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