Recombinant Mouse Anti-Influenza A Antibody scFv Fragment (S139) (CAT#: PABX-118-S (P))
Anti-Influenza A antibody is a Mouse of scFv class that binds to an Influenza A. This antibody was the first antibody to be described with heterosubtypic reactivity, neutralizing strains from multiple subtypes, such as H1, H2, H3, and H13, that cross the HA group barrier.
Specific Inquiry
-1.png)
Figure 1 SDS-PAGE analysis of purified S139/1 IgA and IgG antibodies.
Equal amounts (2.5 mg) of purified S139/1 IgA and IgG antibodies were analyzed by SDS-PAGE under reducing conditions (5%–20% gradient gel) (A). Polymeric forms of purified S139/1 IgA and IgG antibodies (5 mg) were analyzed under nonreducing conditions (3%–10% gradient gel) (B).
Muramatsu, M., Yoshida, R., Yokoyama, A., Miyamoto, H., Kajihara, M., Maruyama, J., ... & Takada, A. (2014). Comparison of antiviral activity between IgA and IgG specific to influenza virus hemagglutinin: increased potential of IgA for heterosubtypic immunity. PLoS One, 9(1), e85582.
-2.png)
Figure 2 Comparison of binding activities of S139/1 IgA and IgG antibodies.
Binding activities of S139/1 IgA (continuous lines) and IgG (dashed lines) were tested in ELISA. Disrupted viral particles of Aichi/H3, WSN/H1, Adachi/H2, and Maryland/H13 were used as antigens. Data are mean values of duplicate wells. EC50 values calculated based on the ELISA data are shown in Table 1.
Muramatsu, M., Yoshida, R., Yokoyama, A., Miyamoto, H., Kajihara, M., Maruyama, J., ... & Takada, A. (2014). Comparison of antiviral activity between IgA and IgG specific to influenza virus hemagglutinin: increased potential of IgA for heterosubtypic immunity. PLoS One, 9(1), e85582.
-3.png)
Figure 3 Comparison of neutralizing activities of S139/1 IgA and IgG antibodies.
Appropriately diluted viruses were mixed with S139/1 IgA (continuous lines) or IgG (dashed lines) at the indicated dilutions. Neutralizing activities were evaluated by counting the number of plaques formed on MDCK cells. IC50 values calculated based on the neutralization curves are shown in Table 3.
Muramatsu, M., Yoshida, R., Yokoyama, A., Miyamoto, H., Kajihara, M., Maruyama, J., ... & Takada, A. (2014). Comparison of antiviral activity between IgA and IgG specific to influenza virus hemagglutinin: increased potential of IgA for heterosubtypic immunity. PLoS One, 9(1), e85582.
Specifications
- Immunogen
- The details of the immunogen for this antibody are not available.
- Host Species
- Mouse
- Derivation
- Mouse
- Type
- scFv
- Specificity
- Tested positive against native Human CD28
- Species Reactivity
- Influenza A virus
- Clone
- S139
- Applications
- WB 1:1000-1:5000
ELISA 1:10000-1:20000
IF 1:100-1:1000
FuncS (assay dependent)
Product Property
- Purity
- >95% by SDS-PAGE and HPLC analysis
- Storage
- Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing of samples.
Applications
- Application Notes
- Assay-depended
Target
- Alternative Names
- Influenza A virus subtype H1N1; H1N1; Influenza A (H1N1) virus; influenza A virus
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-426-S(P) | Recombinant Anti-IAV H1N1 Antibody scFv Fragment | ELISA, WB, FuncS | scFv |
| MHH-426-S(P) | Recombinant Human Anti-IAV H1N1 Antibody scFv Fragment | ELISA, IF, FuncS | scFv |
| PSBL-110 | Recombinant Human Anti-H1N1 Antibody scFv Fragment (del2D1) | WB, ELISA, FuncS | scFv |
| HPAB-2318LY-S(P) | Human Anti-H1N1 Recombinant Antibody; scFv Fragment (HPAB-2318LY-S(P)) | ELISA, Neut | Humanized scfv |
| HPAB-2319LY-S(P) | Human Anti-H1N1 Recombinant Antibody; scFv Fragment (HPAB-2319LY-S(P)) | ELISA, Neut | Humanized scfv |
Single-domain Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NABG-074 | Recombinant Anti-H1N1 VHH Single Domain Antibody | ELISA, IHC, FC, FuncS | Llama VHH |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBL-110 | Recombinant Human Anti-H1N1 Antibody Fab Fragment (del2D1) | WB, ELISA, FuncS | Fab |
| HPAB-2318LY-F(E) | Human Anti-H1N1 Recombinant Antibody; Fab Fragment (HPAB-2318LY-F(E)) | ELISA, Neut | Humanized Fab |
| HPAB-2319LY-F(E) | Human Anti-H1N1 Recombinant Antibody; Fab Fragment (HPAB-2319LY-F(E)) | ELISA, Neut | Humanized Fab |
| HPAB-0795-FY-S(P) | Mouse Anti-H1N1 Recombinant Antibody; scFv Fragment (HPAB-0795-FY-S(P)) | E, N | Mouse scFv |
| HPAB-0796-FY-S(P) | Mouse Anti-H1N1 Recombinant Antibody; scFv Fragment (HPAB-0796-FY-S(P)) | E, N | Mouse scFv |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABX-118 | Recombinant Mouse Anti-Influenza A Antibody (S139) | WB, ELISA, IF, FuncS | IgG |
| PABX-118-F (E) | Recombinant Mouse Anti-Influenza A Antibody Fab Fragment (S139) | WB, ELISA, IF, FuncS | Fab |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-4205 | Hi-Affi™ Recombinant Rabbit Anti-H1N1 Monoclonal Antibody (SI283DS) | WB, ELISA, FC, IP | IgG |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0795-FY | Mouse Anti-H1N1 Recombinant Antibody (HPAB-0795-FY) | E, N | Mouse IgG |
| HPAB-0796-FY | Mouse Anti-H1N1 Recombinant Antibody (HPAB-0796-FY) | E, N | Mouse IgG |
| HPAB-0797-FY | Mouse Anti-H1N1 Recombinant Antibody (HPAB-0797-FY) | E | Mouse IgG |
| HPAB-0798-FY | Mouse Anti-H1N1 Recombinant Antibody (HPAB-0798-FY) | E | Mouse IgG |
| HPAB-0799-FY | Mouse Anti-H1N1 Recombinant Antibody (HPAB-0799-FY) | E | Mouse IgG |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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