Products

anti-KMA immunotoxin K121 (scFv)-Mel (AGTO-L030M)

This immunotoxin was achieved by conjugating/fusing the Anti-KMA scFv to melittin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to myeloma and lymphoma cells. Once bind, melittin is subsequently incorporated into the cell by receptor-mediated endocytosis and inhibits activities of protein kinase C, Ca2+/calmodulin-dependent protein kinase II, myosin light chain kinase and Na+/K+-ATPase (synaptosomal membrane). It was designed for treatment of myeloma and lymphoma.      

Specifications
Host
Mouse
Species Reactivity
Human
Clone
K121
Molecule Class
scFv-Mel
Toxin Description
Melittin is the principal active component of apitoxin (bee venom) and is a powerful stimulator of phospholipase A2. Melittin is a peptide consisting of 26 amino acids with the sequence GIGAVLKVLTTGLPALISWIKRKRQQ. Melittin inhibits protein kinase C, Ca2+/calmodulin-dependent protein kinase II, myosin light chain kinase and Na+/K+-ATPase (synaptosomal membrane) and is a cell membrane lytic factor. Melittin is a small peptide with no disulphide bridge; the N-terminal part of the molecule is predominantly hydrophobic and the C-terminal part is hydrophilic and strongly basic.
Applications
This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
Related Disease
Myeloma and lymphoma
Target
Alternative Names
kappa myeloma antigen; KMA; Myeloma; lymphoma; Melittin; apitoxin; bee venom; Mel

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

Our customer service representatives are available 24 hours a day, from Monday to Sunday. Contact Us
Send Inquiry Now!
Name:
* Phone:
* E-mail Address:
* Service & Products Interested:
Project Description:
* Verification Code:
Please input "biolabs"(case insensitive) as verification code.
Contact Us to Order
Tel: 1-631-871-5806
Fax: 1-631-207-8356
Email:

45-1 Ramsey Road, Shirley, NY 11967, USA     Tel: 1-631-871-5806    Fax: 1-631-207-8356    Email:
Terms of Service-Privacy Policy     © 2007 - 2017 Creative-Biolabs All Rights Reserved