anti-KMA immunotoxin K121 (scFv)-Mel (AGTO-L030M)
This immunotoxin was achieved by conjugating/fusing the Anti-KMA scFv to melittin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to myeloma and lymphoma cells. Once bind, melittin is subsequently incorporated into the cell by receptor-mediated endocytosis and inhibits activities of protein kinase C, Ca2+/calmodulin-dependent protein kinase II, myosin light chain kinase and Na+/K+-ATPase (synaptosomal membrane). It was designed for treatment of myeloma and lymphoma.
- Species Reactivity
- Molecule Class
- Toxin Description
- Melittin is the principal active component of apitoxin (bee venom) and is a powerful stimulator of phospholipase A2. Melittin is a peptide consisting of 26 amino acids with the sequence GIGAVLKVLTTGLPALISWIKRKRQQ. Melittin inhibits protein kinase C, Ca2+/calmodulin-dependent protein kinase II, myosin light chain kinase and Na+/K+-ATPase (synaptosomal membrane) and is a cell membrane lytic factor. Melittin is a small peptide with no disulphide bridge; the N-terminal part of the molecule is predominantly hydrophobic and the C-terminal part is hydrophilic and strongly basic.
- This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
- Related Disease
- Myeloma and lymphoma
- Alternative Names
- kappa myeloma antigen; KMA; Myeloma; lymphoma; Melittin; apitoxin; bee venom; Mel
For lab research use only, not for diagnostic, therapeutic or any in vivo human use.
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