Anti-LGR5 ADCC Enhanced Antibody (BNC101) is an ADCC enhanced antibody produced by our Afuco™ platform. BNC101 is a humanized monoclonal antibody targeting LGR5, that has demonstrated functional activity against Cancer Stem Cells (CSCs) from primary colorectal cancer (CRC) patient samples. In preclinical studies, BNC101 significantly reduces CSC frequency in vivo and prevents tumour re-growth in long term studies. BNC101 also increases survival and inhibits weight loss in a cachexic CRC tumour model. To date BNC101 has shown no evidence of toxicity in preliminary safety analyses.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Download resources about recombinant antibody development and antibody engineering to boost your research.
CAT | Product Name | Application | Type |
---|---|---|---|
NAB-1650-VHH | Recombinant Anti-Human LGR5 VHH Single Domain Antibody | WB, ICC, ChiP, FA, ELISA | Llama VHH |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-490CL | Human Anti-LGR5 Recombinant Antibody (TAB-490CL) | ELISA | Human IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-199CT | Human Anti-LGR5 Recombinant Antibody (TAB-199CT) | ELISA, FC, RIA, IP, WB | Chimeric antibody (mouse/human) |
TAB-199CT-S(P) | Mouse Anti-LGR5 Recombinant Antibody; scFv Fragment (TAB-199CT-S(P)) | ELISA, FC, RIA, IP, WB | Mouse scFv |
TAB-199CT-F(E) | Human Anti-LGR5 Recombinant Antibody; Fab Fragment (TAB-199CT-F(E)) | ELISA, FC, RIA, IP, WB | Chimeric antibody (mouse/human) |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-200CT-S(P) | Mouse Anti-LGR5 Recombinant Antibody; scFv Fragment (TAB-200CT-S(P)) | ELISA, FC, RIA, IP, WB | Mouse scFv |
TAB-200CT-F(E) | Mouse Anti-LGR5 Recombinant Antibody; Fab Fragment (TAB-200CT-F(E)) | ELISA, FC, RIA, IP, WB | Mouse Fab |
TAB-201CT-F(E) | Mouse Anti-LGR5 Recombinant Antibody; Fab Fragment (TAB-201CT-F(E)) | ELISA, FC, RIA, IP, WB | Mouse Fab |
TAB-202CT-F(E) | Mouse Anti-LGR5 Recombinant Antibody; Fab Fragment (TAB-202CT-F(E)) | ELISA, FC, RIA, IP, WB | Mouse Fab |
TAB-203CT-F(E) | Mouse Anti-LGR5 Recombinant Antibody; Fab Fragment (TAB-203CT-F(E)) | ELISA, FC, RIA, IP, WB | Mouse Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-2048 | Hi-Affi™ Recombinant Rabbit Anti-LGR5 Monoclonal Antibody (DS2048AB) | WB, IP, IHC-P | IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0101-CN | Mouse Anti-LGR5 Recombinant Antibody (HPAB-0101-CN) | WB, ELISA, FC, IHC | Mouse IgG |
HPAB-0102-CN | Mouse Anti-LGR5 Recombinant Antibody (HPAB-0102-CN) | WB, ELISA, FC, IHC | Mouse IgG |
HPAB-0105-CN | Human Anti-LGR5 Recombinant Antibody (HPAB-0105-CN) | WB, ELISA, FC, IHC | Chimeric (mouse/human) IgG1, κ |
MRO-1905-CN | Rabbit Anti-LGR5 Polyclonal Antibody (MRO-1905-CN) | WB, IHC | Rabbit IgG |
VS3-CJ177 | Rabbit Anti-LGR5 Recombinant Antibody (VS3-CJ177) | WB, IP, FC | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0101-CN-S(P) | Mouse Anti-LGR5 Recombinant Antibody; scFv Fragment (HPAB-0101-CN-S(P)) | WB, ELISA, FC, IHC | Mouse scFv |
HPAB-0102-CN-S(P) | Mouse Anti-LGR5 Recombinant Antibody; scFv Fragment (HPAB-0102-CN-S(P)) | WB, ELISA, FC, IHC | Mouse scFv |
HPAB-0103-CN-S(P) | Mouse Anti-LGR5 Recombinant Antibody; scFv Fragment (HPAB-0103-CN-S(P)) | WB, ELISA, FC, IHC | Mouse scFv |
HPAB-0104-CN-S(P) | Human Anti-LGR5 Recombinant Antibody; scFv Fragment (HPAB-0104-CN-S(P)) | WB, ELISA, FC, IHC | Human scFv |
HPAB-0106-CN-S(P) | Human Anti-LGR5 Recombinant Antibody; scFv Fragment (HPAB-0106-CN-S(P)) | WB, ELISA, FC, IHC | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0101-CN-F(E) | Mouse Anti-LGR5 Recombinant Antibody; Fab Fragment (HPAB-0101-CN-F(E)) | WB, ELISA, FC, IHC | Mouse Fab |
HPAB-0102-CN-F(E) | Mouse Anti-LGR5 Recombinant Antibody; Fab Fragment (HPAB-0102-CN-F(E)) | WB, ELISA, FC, IHC | Mouse Fab |
HPAB-0103-CN-F(E) | Mouse Anti-LGR5 Recombinant Antibody; Fab Fragment (HPAB-0103-CN-F(E)) | WB, ELISA, FC, IHC | Mouse Fab |
HPAB-0104-CN-F(E) | Human Anti-LGR5 Recombinant Antibody; Fab Fragment (HPAB-0104-CN-F(E)) | WB, ELISA, FC, IHC | Human Fab |
HPAB-0106-CN-F(E) | Human Anti-LGR5 Recombinant Antibody; Fab Fragment (HPAB-0106-CN-F(E)) | WB, ELISA, FC, IHC | Human Fab |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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