Antibody 14G8 is a mouse monoclonal antibody that specifically binds to human LIGHT. It can inhibit human and cynomolgus LIGHT-induced cell apoptosis in the colon carcinoma cell line HT-29.
Figure 1 Inhibition of T-cell proliferation and cytokine production by treatment with SEB specific mAb 20B1, 14G8, 6D3, and 4C7 individually or in different combinations.
SEB-induced T-cell proliferation was measured by ViaLight HS Cell Proliferation kit after 48 h and inhibited in the presence of all three mAb except 4C7. IFN (C) and IL-2 (D) were measured by ELISA in the supernatant of SEB stimulated T-cells. Cytokines were significantly lower in the presence of mAbs relative to conditions with no specific antibody.
Varshney, A. K., Wang, X., Cook, E., Dutta, K., Scharff, M. D., Goger, M. J., & Fries, B. C. (2011). Generation, characterization, and epitope mapping of neutralizing and protective monoclonal antibodies against staphylococcal enterotoxin B-induced lethal shock. Journal of Biological Chemistry, 286(11), 9737-9747.
Figure 2 Western blot analysis of mAbs 20B1, 14G8, 6D3, and 4C7 shows specificity of mAbs for SEB and not for SEA and TSST.
Varshney, A. K., Wang, X., Cook, E., Dutta, K., Scharff, M. D., Goger, M. J., & Fries, B. C. (2011). Generation, characterization, and epitope mapping of neutralizing and protective monoclonal antibodies against staphylococcal enterotoxin B-induced lethal shock. Journal of Biological Chemistry, 286(11), 9737-9747.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
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CAT | Product Name | Application | Type |
---|---|---|---|
TAB-0666CL | Mouse Anti-LIGHT Recombinant Antibody (TAB-0666CL) | ELISA | Mouse IgG |
TAB-0667CL | Mouse Anti-LIGHT Recombinant Antibody (TAB-0667CL) | ELISA | Mouse IgG |
TAB-0668CL | Mouse Anti-LIGHT Recombinant Antibody (TAB-0668CL) | ELISA | Mouse IgG |
TAB-0669CL | Mouse Anti-LIGHT Recombinant Antibody (TAB-0669CL) | ELISA | Mouse IgG |
TAB-0670CL | Mouse Anti-LIGHT Recombinant Antibody (TAB-0670CL) | ELISA | Mouse IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
VS-0723-WK235 | Rabbit Anti-LIGHT Recombinant Antibody (VS-0723-WK235) | ELISA, FC | Rabbit IgG |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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