Anti-Human LRP6 Recombinant Antibody (Fab004) (CAT#: TAB-0705CL)
Recombinant monoclonal antibody Fab004 is a human monoclonal antibody that specifically binds to human LRP6 and can be potentially used in the treatment of Alzheimer's disease.
Specific Inquiry
Inhib
Figure 1 Graphical depiction of the identification of anti-LRP6 antagonistic Fabs which preferentially inhibit Wnt1 induced Wnt signaling.
Inhib
Figure 2 Graphical depiction of the identification of anti-LRP6 antagonistic Fabs which preferentially inhibit Wnt3A induced Wnt signaling.
Figure 3 Graphical depiction of the change in activity when a number of the Fabs are converted to IgGs.
The induction by Wnt1.
Figure 4 Graphical depiction of the change in activity when a number of the Fabs are converted to IgGs.
The induction by Wnt3A.
Figure 5 Graphical demonstration of anti-LRP6 binding molecules' ability to inhibit phosphorylated LRP6 (phospho-LRP6).
Phospho-LRP6 inhibition in PA-1 (ovarian, teratocarcinoma) cells.
Figure 6 Graphical demonstration of anti-LRP6 binding molecules' ability to inhibit phosphorylated LRP6 (phospho-LRP6).
Phospho-LRP6 inhibition in NCI-H929 (multiple myeloma) cells.
Specifications
- Host Species
- Human
- Type
- Human antibody
- Specificity
- Human
- Clone
- Fab004
- Applications
- ELISA, FC, Inhib
- Related Disease
- Alzheimer's disease
Applications
- Application Notes
- The antibody was validated for ELISA, Inhibition, Flow Cytometry. For details, refer to Published Data.
Target
- Alternative Names
- LRP6; low density lipoprotein receptor-related protein 6; ADCAD2; low-density lipoprotein receptor-related protein 6; LRP-6
- Gene ID
- 4040
- UniProt ID
- O75581
Related Resources
Canonical Wnt Signaling Pathway
JAK-STAT Signaling Pathway
Non-Canonical Wnt Signaling Pathway
Hepatocellular Carcinoma
Pancreatic Cancer
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "Clone Fab004"
See other products for "LRP6"
Chimeric Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0115CL | Chimeric Anti-Human LRP6 Recombinant Antibody | ELISA, FC, Inhib, FuncS, Internalization | Chimeric (mouse/human) |
| TAB-0115CL-S(P) | Anti-Human LRP6 Recombinant Antibody scFv Fragment | ELISA, FC, Inhib, FuncS, Internalization | Chimeric (mouse/human) |
| TAB-0115CL-F(E) | Anti-Human LRP6 Recombinant Antibody Fab Fragment | ELISA, FC, Inhib, FuncS, Internalization | Chimeric (mouse/human) |
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0349CL | Human Anti-LRP6 Recombinant Antibody (TAB-0349CL) | ELISA | Humanized IgG1, κ |
| TAB-0350CL | Human Anti-LRP6 Recombinant Antibody (TAB-0350CL) | ELISA | Humanized IgG1, κ |
| TAB-0351CL | Human Anti-LRP6 Recombinant Antibody (TAB-0351CL) | ELISA | Humanized IgG1, κ |
| TAB-0352CL | Human Anti-LRP6 Recombinant Antibody (TAB-0352CL) | ELISA | Humanized IgG1, κ |
| TAB-0353CL | Human Anti-LRP6 Recombinant Antibody (TAB-0353CL) | ELISA | Humanized IgG1, κ |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0706CL | Anti-Human LRP6 Recombinant Antibody (Fab002) | ELISA, FC, Inhib | Human antibody |
| TAB-0705CL-F(E) | Anti-Human LRP6 Recombinant Antibody Fab Fragment (Fab004) | ELISA, FC | Human antibody |
| TAB-0706CL-F(E) | Anti-Human LRP6 Recombinant Antibody Fab Fragment (Fab002) | ELISA, FC | Human antibody |
| TAB-0707CL-F(E) | Human Anti-LRP6 Recombinant Antibody; Fab Fragment (TAB-0707CL-F(E)) | ELISA | Human Fab |
| TAB-0708CL-F(E) | Human Anti-LRP6 Recombinant Antibody; Fab Fragment (TAB-0708CL-F(E)) | ELISA | Human Fab |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0112CL-S(P) | Anti-Human LRP6 Recombinant Antibody scFv Fragment (1433.8) | ELISA, FC, Inhib, FuncS, Internalization | |
| TAB-0113CL-S(P) | Anti-Human LRP6 Recombinant Antibody scFv Fragment (1470.2) | ELISA, FC, Inhib, FuncS, Internalization | |
| TAB-0114CL-S(P) | Anti-Human LRP6 Recombinant Antibody scFv Fragment (1903.1) | ELISA, FC, Inhib, FuncS, Internalization | |
| TAB-0703CL-F(E) | Mouse Anti-LRP6 Recombinant Antibody; Fab Fragment (TAB-0703CL-F(E)) | ELISA, IHC | Mouse Fab |
| TAB-0704CL-F(E) | Mouse Anti-LRP6 Recombinant Antibody; Fab Fragment (TAB-0704CL-F(E)) | ELISA | Mouse Fab |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBC-205 | Mouse Anti-LRP6 Recombinant Antibody (clone mAb135); scFv Fragment | ELISA, WB, FC | Mouse scFv |
| HPAB-0007-FY-S(P) | Human Anti-LRP6 Recombinant Antibody; scFv Fragment (HPAB-0007-FY-S(P)) | ELISA | Human scFv |
| HPAB-0012-FY-S(P) | Human Anti-LRP6 Recombinant Antibody; scFv Fragment (HPAB-0012-FY-S(P)) | FuncS, Cyt | Human scFv |
| HPAB-0647-WJ-S(P) | Human Anti-LRP6 Recombinant Antibody; scFv Fragment (HPAB-0647-WJ-S(P)) | ELISA | Human scFv |
| HPAB-0648-WJ-S(P) | Human Anti-LRP6 Recombinant Antibody; scFv Fragment (HPAB-0648-WJ-S(P)) | ELISA | Human scFv |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2087 | Hi-Affi™ Recombinant Rabbit Anti-LRP6 Monoclonal Antibody (DS2087AB) | ICC/IF, WB | IgG |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0647-WJ | Human Anti-LRP6 Recombinant Antibody (HPAB-0647-WJ) | ELISA | Human IgG |
| HPAB-0648-WJ | Human Anti-LRP6 Recombinant Antibody (HPAB-0648-WJ) | ELISA | Human IgG |
| HPAB-0649-WJ | Human Anti-LRP6 Recombinant Antibody (HPAB-0649-WJ) | ELISA | Human IgG |
| HPAB-0650-WJ | Human Anti-LRP6 Recombinant Antibody (HPAB-0650-WJ) | ELISA | Human IgG |
| HPAB-0651-WJ | Human Anti-LRP6 Recombinant Antibody (HPAB-0651-WJ) | ELISA | Human IgG |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0647-WJ-F(E) | Human Anti-LRP6 Recombinant Antibody; Fab Fragment (HPAB-0647-WJ-F(E)) | ELISA | Human Fab |
| HPAB-0648-WJ-F(E) | Human Anti-LRP6 Recombinant Antibody; Fab Fragment (HPAB-0648-WJ-F(E)) | ELISA | Human Fab |
| HPAB-0649-WJ-F(E) | Human Anti-LRP6 Recombinant Antibody; Fab Fragment (HPAB-0649-WJ-F(E)) | ELISA | Human Fab |
| HPAB-0650-WJ-F(E) | Human Anti-LRP6 Recombinant Antibody; Fab Fragment (HPAB-0650-WJ-F(E)) | ELISA | Human Fab |
| HPAB-0651-WJ-F(E) | Human Anti-LRP6 Recombinant Antibody; Fab Fragment (HPAB-0651-WJ-F(E)) | ELISA | Human Fab |
Single-domain Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NBD-0060-YJ-VHH | Camelid Anti-LRP6 Recombinant Single Domain Antibody (L-P2-B10) | ELISA, Block | Camelid VHH |
| NBD-0061-YJ-VHH | Camelid Anti-LRP6 Recombinant Single Domain Antibody (L-P2-D07) | ELISA, Block | Camelid VHH |
| NBD-0062-YJ-VHH | Camelid Anti-LRP6 Recombinant Single Domain Antibody (L-P2-H07) | ELISA | Camelid VHH |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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