Anti-Lewis Y Recombinant Antibody (BR55-2) (CAT#: TAB-0018CL)
Antibody BR55-2 is a mouse monoclonal antibody against Y oligosaccharide. It can bind to human LeY expressing tumor cells.
Specific Inquiry
Activ
Figure 1 Anti-Lewis Y monoclonal antibody BR55-2 induced caspase-3/7 activation in HCC1954.
HCC1954 (A) or MCF-7 (B) cells were incubated with various concentrations of BR55-2 and, after 24 hours of incubation, caspase-3 activity was measured. Two-way ANOVA with Bonferroni post-test was performed and P values are shown. Bar heights ± error bars denote means ± SDs of three technical replicates.
Hutchins, L. F., Makhoul, I., Emanuel, P. D., Pennisi, A., Siegel, E. R., Jousheghany, F., ... & Kieber-Emmons, T. (2017). Targeting tumor-associated carbohydrate antigens: a phase I study of a carbohydrate mimetic-peptide vaccine in stage IV breast cancer subjects. Oncotarget, 8(58), 99161.
Inhib
Figure 2 Anti-Lewis Y monoclonal antibody BR55-2 induced caspase-3/7 growth inhibition in HCC1954.
The effect of BR55-2 on cell survival was measured after 24 (A) and 48 (B) hours of incubation using CCK-8 kit. Symbols ± error bars at each tested antibody concentration denote means ± SDs of three technical replicates. BR55-2 negatively affected viability of HCC1954 cells at all concentrations after 24 and 48 hours (P < 0.001), while no statistically signicant growth inhibition was observed in MCF-7 cells (P> 0.05).
Hutchins, L. F., Makhoul, I., Emanuel, P. D., Pennisi, A., Siegel, E. R., Jousheghany, F., ... & Kieber-Emmons, T. (2017). Targeting tumor-associated carbohydrate antigens: a phase I study of a carbohydrate mimetic-peptide vaccine in stage IV breast cancer subjects. Oncotarget, 8(58), 99161.
Specifications
- Host Species
- Mouse
- Clone
- BR55-2
- Applications
- Activ, Inhib
- Related Disease
- LeY expressing tumors
Applications
- Application Notes
- This antibody has been reported for use in Activation and Inhibition.
Target
- Alternative Names
- Lewis Y; Lewis Y antigen; Lewis-Y; Lewis-Y antigen; Lewis(y) antigen; Lewis(y)
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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See other products for "Clone BR55-2"
See other products for "Lewis Y"
Single-domain Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-1634-VHH | Recombinant Anti-Human Lewis Y VHH Single Domain Antibody | WB, IP, ChiP, Neut, ELISA | Llama VHH |
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-730 | Humanized Anti-Lewis Y Recombinant Antibody (clone CBR96) | IP, IF, FuncS, FC, Neut, ELISA, ICC | Humanized (from mouse) IgG1, κ |
| TAB-0015CL-F(E) | Anti-Lewis Y Recombinant Antibody Fab Fragment (MB311) | FC | Humanized Antibody |
| TAB-0016CL-F(E) | Anti-Lewis Y Recombinant Antibody Fab Fragment (Hu3s193) | ELISA, BI | Humanized Antibody |
| TAB-0017CL-F(E) | Anti-Lewis Y Recombinant Antibody Fab Fragment (hABL364) | ELISA | Humanized Antibody |
| TAB-0019CL-F(E) | Human Anti-Lewis Y Recombinant Antibody; Fab Fragment (TAB-0019CL-F(E)) | FuncS | Humanized Fab |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0650CL | Anti-Human Lewis Y Recombinant Antibody (3S193) | Cyt, ELISA | |
| TAB-0018CL-S(P) | Anti-Lewis Y Recombinant Antibody scFv Fragment (BR55-2) | FuncS, Inhib | |
| TAB-0018CL-F(E) | Anti-Lewis Y Recombinant Antibody Fab Fragment (BR55-2) | FuncS, Inhib | |
| TAB-0650CL-F(E) | Anti-Human Lewis Y Recombinant Antibody Fab Fragment (3S193) | ELISA | |
| PABX-131-S (P) | Recombinant Mouse Anti-LewisY Antibody scFv Fragment (MBR96) | WB, Neut, FuncS | scFv |
Fc Glycosylation
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-044LC | Recombinant Anti-Human Lewis Y Antibody (Fc glycosylation) | ELISA | Humanized antibody |
| Gly-045LC | Recombinant Anti-Human Lewis Y Antibody (Fc glycosylation) | ELISA | Humanized antibody |
| Gly-103LC | Recombinant Anti-Human Lewis Y Antibody (Fc glycosylation) | ELISA | Humanized antibody |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABX-003-S (P) | Recombinant Human Anti-LewisY Antibody scFv Fragment (hu3S193) | WB, IF, FuncS | scFv |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0207CQ | Mouse Anti-Lewis Y Recombinant Antibody (clone MSL5) | ELISA, FC, IHC | Mouse IgG |
| FAMAB-1327CQ | Human Anti-Lewis Y Recombinant Antibody (clone BR96) | IHC, Cyt | Human IgG1 |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0207CQ-F(E) | Mouse Anti-Lewis Y Recombinant Antibody (clone MSL5); Fab Fragment | FC, IHC | Mouse Fab |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0207CQ-S(P) | Mouse Anti-Lewis Y Recombinant Antibody (clone MSL5); scFv Fragment | FC, IHC | Mouse scFv |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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