Anti-Human Lewis Y Recombinant Antibody (MB 311) (CAT#: TAB-488CL)

Recombinant Humanized monoclonal antibody expressed in CHO binding to Human Lewis Y. MB311 is a fully humanized monoclonal antibody recognizing the tumor-associated antigen Lewis Y. This carbohydrate antigen is expressed on 60-90 % of all epithelial cancers, with only limited expression on normal tissues, and thus represents an attractive target for cancer immunotherapy. MB311 was well tolerated, permeated into malignant effusion and attracted immune cells leading to decreased tumor cell counts in the effusion.


Specific Inquiry
  • Size:
  • Conjugation:
  • Endotoxin:
  • Purity:
  • Fc Engineering:
  • Published Data
  • Datasheet
  • MSDS
  • COA
Cyt

Figure 1 Pharmacokinetics (Titer) and Pharmacodynamics (CDC and ADCC) of MB311.

Figure 1 Pharmacokinetics (Titer) and Pharmacodynamics (CDC and ADCC) of MB311.

Bauernhofer, T., Samonigg, H., Regitnik, P., Weitzer, W., Lileg, B., Waxenecker, G., ... & Fido, M. (2013). Safety and therapeutic efficacy of the Lewis Y carbohydrate specific humanized antibody MB311 in patients with malignant effusion. Journal of Cancer Therapy, 2014.


Specifications

  • Derivation
  • Humanized
  • Type
  • Antibody
  • Species Reactivity
  • Human
  • Applications
  • Cyt
  • Related Disease
  • Cancer

Product Property

  • Purity
  • >95% as judged by SDS-polyacrylamide gel electrophoresis
  • Storage
  • 4°C or -20°C, avoid repeated freezing and thawing.

Applications

  • Application Notes
  • This antibody has been tested for use in Cytotoxicity. It's recommended that the optimal antibody concentration, dilution, incubition time, etc. be carefully titrated in specific assays.

Target

  • Alternative Names
  • Lewis Y; Lewis Y antigen; Lewis-Y; Lewis-Y antigen; Lewis(y) antigen; Lewis(y)

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "Lewis Y"

Single-domain Antibody

CAT Product Name Application Type
NAB-1634-VHH Recombinant Anti-Human Lewis Y VHH Single Domain Antibody WB, IP, ChiP, Neut, ELISA Llama VHH

Human Antibody

CAT Product Name Application Type
PABX-003-S (P) Recombinant Human Anti-LewisY Antibody scFv Fragment (hu3S193) WB, IF, FuncS scFv

Recombinant Antibody

Fab Fragment Antibody

scFv Fragment Antibody

CAT Product Name Application Type
FAMAB-0207CQ-S(P) Mouse Anti-Lewis Y Recombinant Antibody (clone MSL5); scFv Fragment FC, IHC Mouse scFv

Customer Reviews and Q&As

Submit a review or a question
There are currently no Customer reviews or questions for TAB-488CL. Click the button above to contact us or submit your feedback about this product.
View the frequently asked questions answered by Creative Biolabs Support.

For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Send Inquiry

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

© 2024 Creative Biolabs.
  • 0
  • 0
Cart

    Go to compare