Anti-MAGEA1 immunotoxin (scFv)-ABR (CAT#: AGTO-G048A)
This immunotoxin was achieved by conjugating/fusing the Anti-MAGEA1 scFv to Abrin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to tumor cells. Once bind, the abrin is subsequently engulfed and enters the inner parts of the cell where it reacts with a ribosomal subunit. It interferes with the normal protein synthesis process of the cell and then inhibits cell protein synthesis. It was designed for treatment of hepatocellular carcinoma.
Specific Inquiry
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to cytosol.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2620/if_selected.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to cytosol.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2620/if_selected.jpg
Figure 2 Cerebral cortex
(Neuronal cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2620/6443_B_8_5.jpg
(Neuronal cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2620/6443_B_8_5.jpg
Figure 3 Kidney
(Cells in glomeruli Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous Cells in tubules Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2620/6443_A_7_5.jpg
(Cells in glomeruli Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous Cells in tubules Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2620/6443_A_7_5.jpg
Figure 4 High expression in testis.
(Cells in seminiferous ducts Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2620/6443_A_6_6.jpg
(Cells in seminiferous ducts Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2620/6443_A_6_6.jpg
Figure 5 RNA cell line category: Cell line enhanced (HEL, HMC-1, RPMI-8226, U-2 OS, U-266/70, U-266/84)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000198681-MAGEA1
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000198681-MAGEA1
Specifications
- Host Species
- Mouse
- Species Reactivity
- Human
- Molecule Class
- scFv-ABR
- Toxin Description
- Abrin is a highly toxic toxalbumin found in the seeds of the rosary pea (jequirity pea). It is a ribosome inhibiting protein and the toxin can also be found in the seeds of the castor oil plant. Abrin is a water-soluble lectin. Abrin in powdered form is yellowish-white. It is a stable substance and can withstand extreme environmental conditions.
- Applications
- This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
- Related Disease
- hepatocellular carcinoma
Target
- Alternative Names
- MAGEA1; melanoma antigen family A, 1; CT1.1; MAGE1; melanoma-associated antigen 1; antigen MZ2-E; MAGE-1 antigen; melanoma antigen MAGE-1; cancer/testis antigen 1.1; melanoma antigen family A 1; melanoma-associated antigen MZ2-E; cancer/testis antigen family 1, member 1; melanoma antigen family A, 1 (directs expression of antigen MZ2-E); Abrin; Abrin variant; Abrin-A; Abrin A; ABR
- Gene ID
- 4100
- UniProt ID
- P43355
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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See other products for "MAGEA1"
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1637z | Mouse Anti-MAGEA1 Recombinant Antibody (clone 33D1) | FC, IF, IHC | Mouse IgG1, κ |
| MOB-1121CT | Recombinant Mouse anti-Human MAGEA1 Monoclonal antibody (NB565) | WB | |
| HPAB-M0143-YC | Human Anti-MAGEA1 Recombinant Antibody (clone M/YC-15) | ELISA, WB | Human IgG |
MHC Tetramer for Cancer
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2122 | Hi-Affi™ Recombinant Rabbit Anti-MAGEA1 Monoclonal Antibody (DS2122AB) | WB, ICC, FC | IgG |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-M0143-YC-S(P) | Human Anti-MAGEA1 Recombinant Antibody (clone M/YC-15); scFv Fragment | ELISA, WB | Human scFv |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-M0143-YC-F(E) | Human Anti-MAGEA1 Recombinant Antibody (clone M/YC-15); Fab Fragment | ELISA, WB | Human Fab |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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