Anti-MAGEA1 immunotoxin (scFv)-ABR (AGTO-G048A)
This immunotoxin was achieved by conjugating/fusing the Anti-MAGEA1 scFv to Abrin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to tumor cells. Once bind, the abrin is subsequently engulfed and enters the inner parts of the cell where it reacts with a ribosomal subunit. It interferes with the normal protein synthesis process of the cell and then inhibits cell protein synthesis. It was designed for treatment of hepatocellular carcinoma.
- Species Reactivity
- Molecule Class
- Toxin Description
- Abrin is a highly toxic toxalbumin found in the seeds of the rosary pea (jequirity pea). It is a ribosome inhibiting protein and the toxin can also be found in the seeds of the castor oil plant. Abrin is a water-soluble lectin. Abrin in powdered form is yellowish-white. It is a stable substance and can withstand extreme environmental conditions.
- This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
- Related Disease
- hepatocellular carcinoma
- Alternative Names
- MAGEA1; melanoma antigen family A, 1; CT1.1; MAGE1; melanoma-associated antigen 1; antigen MZ2-E; MAGE-1 antigen; melanoma antigen MAGE-1
- Entrez Gene ID
- UniProt ID
For lab research use only, not for diagnostic, therapeutic or any in vivo human use.
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