Recombinant monoclonal antibody 1E8a is a mouse monoclonal antibody that specifically binds to human MC4R and can be potentially used in the treatment of cachexia.
Figure 1 Immunocytochemistry of HEK-293 cells transfected with hMC4R or hMC3R.
The specific membrane labeling was seen in HEK-293 cells expressing hMC4R when incubated with the mAb 1E8a.
Peter, J. C., Lecourt, A. C., Weckering, M., Zipfel, G., Niehoff, M. L., Banks, W. A., & Hofbauer, K. G. (2010). A pharmacologically active monoclonal antibody against the human melanocortin-4 receptor: effectiveness after peripheral and central administration. Journal of pharmacology and experimental therapeutics, 333(2), 478-490.
Figure 2 The inhibition of hMC4R immunoprecipitation by mAb 1E8a using increasing concentration of the NT peptide.
Results are presented as percentage of inhibition of the
signal obtained without NT peptide in function of the [NT].
Mean=S.D. are calculated from three independent experiments.
n=5 measurements/experiment.
Peter, J. C., Lecourt, A. C., Weckering, M., Zipfel, G., Niehoff, M. L., Banks, W. A., & Hofbauer, K. G. (2010). A pharmacologically active monoclonal antibody against the human melanocortin-4 receptor: effectiveness after peripheral and central administration. Journal of pharmacology and experimental therapeutics, 333(2), 478-490.
Figure 3 Western blot probed with an anti-His6 Ab that revealed the presence of the His6-tagged scFv 1E8a.
Purification of the scFv 1E8a by Ni-NTA chromatography.
Peter, J. C., Lecourt, A. C., Weckering, M., Zipfel, G., Niehoff, M. L., Banks, W. A., & Hofbauer, K. G. (2010). A pharmacologically active monoclonal antibody against the human melanocortin-4 receptor: effectiveness after peripheral and central administration. Journal of pharmacology and experimental therapeutics, 333(2), 478-490.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Download resources about recombinant antibody development and antibody engineering to boost your research.
CAT | Product Name | Application | Type |
---|---|---|---|
NAB-1714-sdAb | Recombinant Anti-Human MC4R VHH Single Domain Antibody | WB, ICC, ChiP, FA, ELISA | Llama VHH |
CAT | Product Name | Application | Type |
---|---|---|---|
MOB-2008z | Mouse Anti-MC4R Recombinant Antibody (clone 25B11) | WB, ELISA, IF, IP | Mouse IgG2a, κ |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-2186 | Hi-Affi™ Recombinant Rabbit Anti-MC4R Monoclonal Antibody (DS2186AB) | WB | IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
MHC-LC2688 | PE-A*02:01/Human MC4R (SIIDPLIYA) MHC Tetramer | FCM | |
MHC-LC2694 | PE-A*02:01/Human MC4R (TILIGVFVV) MHC Tetramer | FCM | |
MHC-LC2930 | APC-A*02:01/Human MC4R (SIIDPLIYA) MHC Tetramer | FCM |
There are currently no Customer reviews or questions for TAB-0733CL. Click the button above to contact us or submit your feedback about this product.
View the frequently asked questions answered by Creative Biolabs Support.
For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.