Anti-Human MC4R Recombinant Antibody (1E8a) (CAT#: TAB-0733CL)

Recombinant monoclonal antibody 1E8a is a mouse monoclonal antibody that specifically binds to human MC4R and can be potentially used in the treatment of cachexia.


Specific Inquiry
  • Size:
  • Conjugation:
  • Endotoxin:
  • Purity:
  • Fc Engineering:
  • Published Data
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
ICC

Figure 1 Immunocytochemistry of HEK-293 cells transfected with hMC4R or hMC3R.

Figure 1 Immunocytochemistry of HEK-293 cells transfected with hMC4R or hMC3R.

The specific membrane labeling was seen in HEK-293 cells expressing hMC4R when incubated with the mAb 1E8a.

Peter, J. C., Lecourt, A. C., Weckering, M., Zipfel, G., Niehoff, M. L., Banks, W. A., & Hofbauer, K. G. (2010). A pharmacologically active monoclonal antibody against the human melanocortin-4 receptor: effectiveness after peripheral and central administration. Journal of pharmacology and experimental therapeutics, 333(2), 478-490.

IP

Figure 2 The inhibition of hMC4R immunoprecipitation by mAb 1E8a using increasing concentration of the NT peptide.

Figure 2 The inhibition of hMC4R immunoprecipitation by mAb 1E8a using increasing concentration of the NT peptide.

Results are presented as percentage of inhibition of the
signal obtained without NT peptide in function of the [NT].
Mean=S.D. are calculated from three independent experiments.
n=5 measurements/experiment.

Peter, J. C., Lecourt, A. C., Weckering, M., Zipfel, G., Niehoff, M. L., Banks, W. A., & Hofbauer, K. G. (2010). A pharmacologically active monoclonal antibody against the human melanocortin-4 receptor: effectiveness after peripheral and central administration. Journal of pharmacology and experimental therapeutics, 333(2), 478-490.

WB

Figure 3 Western blot probed with an anti-His6 Ab that revealed the presence of the His6-tagged scFv 1E8a.

Figure 3 Western blot probed with an anti-His6 Ab that revealed the presence of the His6-tagged scFv 1E8a.

Purification of the scFv 1E8a by Ni-NTA chromatography.

Peter, J. C., Lecourt, A. C., Weckering, M., Zipfel, G., Niehoff, M. L., Banks, W. A., & Hofbauer, K. G. (2010). A pharmacologically active monoclonal antibody against the human melanocortin-4 receptor: effectiveness after peripheral and central administration. Journal of pharmacology and experimental therapeutics, 333(2), 478-490.


Specifications

  • Immunogen
  • Free peptide NT4
  • Host Species
  • Mouse
  • Specificity
  • Human
  • Clone
  • 1E8a
  • Applications
  • ICC, IP, WB
  • Related Disease
  • Cachexia

Applications

  • Application Notes
  • The MC4R antibody has been reported in applications of Immunocytochemistry, Immunoprecipitation, Western Blot.

Target

  • Alternative Names
  • MC4R; melanocortin 4 receptor; melanocortin receptor 4; MC4-R

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "Clone 1E8a"

See other products for "MC4R"

Customer Reviews and Q&As

Submit a review or a question
There are currently no Customer reviews or questions for TAB-0733CL. Click the button above to contact us or submit your feedback about this product.
View the frequently asked questions answered by Creative Biolabs Support.

For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Send Inquiry

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

© 2024 Creative Biolabs.
  • 0
  • 0
Cart

    Go to compare