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Anti-MLK Intrabody [(D-Arg)9] (IAB-B058(A))

Recombinant anti-MLK intrabody linked to (D-Arg)9 works within cells to bind human MLK, expressed in 293T cells. It specifically inhibits the expression or activity of one or more MLKs for use in medical treatment.      

Specifications
Immunogen
human Mixed lineage kinases
Host
mouse
Type
scFv-(D-Arg)9
Cell Penetrating Peptide
(D-Arg)9
It has been proven that polyarginine peptides composed of nine arginine amino acids (Arg-9) are able to translocate across cells very efficiently. This raises the question if molecular dynamics simulations would show a similar pathway for this highly hydrophilic and charged peptide as predicted for the Tat peptide. The simplicity of Arg-9 over other CPPs also helps isolate the role of the Arg sidechain on the translocation without the effect of other sidechains. Therefore, in this work we study computationally the translocation of Arg-9 through a lipid bilayer and show that the translocation mechanism is the same as for the Tat peptide.
Species Reactivity
human
Applications
Can be useful in applications such as: Enzyme-linked Immunosorbent Assay; Western blot; Immunocytochemistry; Functional studies
Target
Alternative Names
hMLKL; Mixed lineage kinase domain like; Mixed lineage kinase domain like protein; Mixed lineage kinase domain-like protein; Mlkl; MLKL_HUMAN

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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