Anti-Human MPL Recombinant Antibody (VB22B) (CAT#: TAB-157CQ)

The antibody binds to the domain I sequence of MPL with high affinity (10 nM). It can be potentially used in the treatment of congenital amegakaryocytic thrombocytopenia.


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  • Gene Expression
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ELISA

Figure 1 Thrombopoietin receptor agonistic activity of purified hVB22B (scFv)2 peak 1 (open circle) and peak 2 (black diamond), and hVB22B (scFv)2 variant 1 (black square) and variant 2 (open triangle) in M-07e cells.

Figure 1 Thrombopoietin receptor agonistic activity of purified hVB22B (scFv)2 peak 1 (open circle) and peak 2 (black diamond), and hVB22B (scFv)2 variant 1 (black square) and variant 2 (open triangle) in M-07e cells.

Igawa, T., Tsunoda, H., Kikuchi, Y., Yoshida, M., Tanaka, M., Koga, A., ... & Tsuchiya, M. (2010). VH/VL interface engineering to promote selective expression and inhibit conformational isomerization of thrombopoietin receptor agonist single-chain diabody. Protein Engineering, Design & Selection,  23(8), 667-677.


Specifications

  • Immunogen
  • BaF3-human Mpl
  • Host Species
  • Mouse
  • Specificity
  • Human
  • Species Reactivity
  • Human, Cynomolgus monkey
  • Clone
  • VB22B
  • Applications
  • ELISA, FC
  • Related Disease
  • Congenital amegakaryocytic thrombocytopenia

Applications

  • Application Notes
  • This antibody has been tested for use in ELISA, Flow Cytometry. It's recommended that the optimal antibody concentration, dilution, incubition time, etc. be carefully titrated in specific assays.

Target

  • Alternative Names
  • MPL; MPL proto-oncogene, thrombopoietin receptor; MPLV; TPOR; C-MPL; CD110; THCYT2; thrombopoietin receptor; TPO-R; proto-oncogene c-Mpl; myeloproliferative leukemia protein; myeloproliferative leukemia virus oncogene

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

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Agonistic Antibody

CAT Product Name Application Type
MOB-108LC Recombinant Human Anti-Human MPL Agonist Antibody (12B5) FC, FunS, ELISA Human antibody
MOB-109LC Recombinant Human Anti-Human MPL Agonist Antibody (12D5) FC, FunS, ELISA Human antibody
MOB-110LC Recombinant Human Anti-Human MPL Agonist Antibody (12E10) FC, FunS, ELISA Human antibody

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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