The antibody binds to the domain I sequence of MPL with high affinity (10 nM). It can be potentially used in the treatment of congenital amegakaryocytic thrombocytopenia.
Figure 1 Thrombopoietin receptor agonistic activity of purified hVB22B (scFv)2 peak 1 (open circle) and peak 2 (black diamond), and hVB22B (scFv)2 variant 1 (black square) and variant 2 (open triangle) in M-07e cells.
Igawa, T., Tsunoda, H., Kikuchi, Y., Yoshida, M., Tanaka, M., Koga, A., ... & Tsuchiya, M. (2010). VH/VL interface engineering to promote selective expression and inhibit conformational isomerization of thrombopoietin receptor agonist single-chain diabody. Protein Engineering, Design & Selection, 23(8), 667-677.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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CAT | Product Name | Application | Type |
---|---|---|---|
TAB-155CQ | Human Anti-MPL Recombinant Antibody (TAB-155CQ) | ELISA, FC, FuncS | Human IgG1 |
TAB-155CQ-S(P) | Human Anti-MPL Recombinant Antibody; scFv Fragment (TAB-155CQ-S(P)) | ELISA, FC, WB | Human scFv |
TAB-155CQ-F(E) | Human Anti-MPL Recombinant Antibody; Fab Fragment (TAB-155CQ-F(E)) | ELISA, FC, WB | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-156CQ | Anti-Human MPL Recombinant Antibody (TA136) | ELISA, FC | |
TAB-156CQ-S(P) | Anti-Human MPL Recombinant Antibody scFv Fragment (TA136) | ELISA, FC | |
TAB-157CQ-S(P) | Anti-Human MPL Recombinant Antibody scFv Fragment (VB22B) | ELISA, FC | |
TAB-156CQ-F(E) | Anti-Human MPL Recombinant Antibody Fab Fragment (TA136) | ELISA, FC | |
TAB-157CQ-F(E) | Anti-Human MPL Recombinant Antibody Fab Fragment (VB22B) | ELISA, FC |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-2272 | Hi-Affi™ Recombinant Rabbit Anti-MPL Monoclonal Antibody (DS2272AB) | FC, WB | IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
MOB-108LC | Recombinant Human Anti-Human MPL Agonist Antibody (12B5) | FC, FunS, ELISA | Human antibody |
MOB-109LC | Recombinant Human Anti-Human MPL Agonist Antibody (12D5) | FC, FunS, ELISA | Human antibody |
MOB-110LC | Recombinant Human Anti-Human MPL Agonist Antibody (12E10) | FC, FunS, ELISA | Human antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0566-CN-S(P) | Mouse Anti-MPL Recombinant Antibody; scFv Fragment (HPAB-0566-CN-S(P)) | ELISA, FC, Block | Mouse scFv |
HPAB-0567-CN-S(P) | Mouse Anti-MPL Recombinant Antibody; scFv Fragment (HPAB-0567-CN-S(P)) | ELISA, FC, Block | Mouse scFv |
HPAB-0568-CN-S(P) | Mouse Anti-MPL Recombinant Antibody; scFv Fragment (HPAB-0568-CN-S(P)) | ELISA, FC, Block | Mouse scFv |
HPAB-S0096-YC-S(P) | Human Anti-MPL Recombinant Antibody (clone 10D10); scFv Fragment | ELISA, Agonist | Human scFv |
HPAB-S0097-YC-S(P) | Human Anti-MPL Recombinant Antibody (clone 5E5); scFv Fragment | ELISA, Agonist | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0566-CN-F(E) | Mouse Anti-MPL Recombinant Antibody; Fab Fragment (HPAB-0566-CN-F(E)) | ELISA, FC, Block | Mouse Fab |
HPAB-0567-CN-F(E) | Mouse Anti-MPL Recombinant Antibody; Fab Fragment (HPAB-0567-CN-F(E)) | ELISA, FC, Block | Mouse Fab |
HPAB-0568-CN-F(E) | Mouse Anti-MPL Recombinant Antibody; Fab Fragment (HPAB-0568-CN-F(E)) | ELISA, FC, Block | Mouse Fab |
HPAB-0411-YC-F(E) | Mouse Anti-MPL Recombinant Antibody; Fab Fragment (HPAB-0411-YC-F(E)) | FC, ELISA | Mouse Fab |
HPAB-0412-YC-F(E) | Human Anti-MPL Recombinant Antibody (clone 7-10G4344uhm); Fab Fragment | FC, FuncS | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0411-YC | Mouse Anti-MPL Recombinant Antibody (HPAB-0411-YC) | FC, ELISA | Mouse IgG1, κ |
HPAB-0412-YC | Human Anti-MPL Recombinant Antibody (clone 7-10G4344uhm) | FC, FuncS | Human IgG |
HPAB-1580-FY | Mouse Anti-MPL Recombinant Antibody (HPAB-1580-FY) | WB, FC, ELISA | Mouse IgG |
HPAB-1581-FY | Mouse Anti-MPL Recombinant Antibody (HPAB-1581-FY) | FC | Mouse IgG |
VS3-XY1093 | Mouse Anti-MPL Recombinant Antibody (clone 1H2) | ELISA, WB, FC | Mouse IgG2b |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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