This antibody which binds to myostatin can be potentially used in the treatment or prophylaxis of diseases associated with any one or a combination of decreased muscle mass, muscle strength and muscle function.
Figure 1 shows binding of the HOLO humanised anti-myostatin antibody to myostatin following treatment of the antibody with or without ammonium bicarbonate which can induce deamidation of the antibody.
Figure 3 shows the H2L2-N54Q, H2L2-C91S, H2L2-N54Q-C91S humanised anti-myostatin antibody variants, H0L0, H2L2 and 10B3C inhibition of myostatin- induced activation of cell signalling, resulting in luciferase expression in A204 cells.
Figure 4 shows the binding of purified H2L2-N54Q, H2L2-C91S, H2L2- N54Q-C91S humanised anti-myostatin antibody variants, H2L2, HOLO and 10B3C (HCLC) to myostatin by ELISA.
Figure 5 shows 10B3, 10B3C, HOLO and H2L2 inhibition of myostatin- induced activation of cell signalling, resulting in luciferase expression in A204 cells.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Download resources about recombinant antibody development and antibody engineering to boost your research.
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-0476CL | Mouse Anti-MSTN Recombinant Antibody (TAB-0476CL) | ELISA, WB | Mouse IgG |
TAB-0477CL | Mouse Anti-MSTN Recombinant Antibody (TAB-0477CL) | ELISA, WB | Mouse IgG |
TAB-0478CL | Mouse Anti-MSTN Recombinant Antibody (TAB-0478CL) | ELISA, WB | Mouse IgG |
TAB-0479CL | Mouse Anti-MSTN Recombinant Antibody (TAB-0479CL) | ELISA, WB | Mouse IgG |
TAB-0480CL | Mouse Anti-MSTN Recombinant Antibody (TAB-0480CL) | ELISA, WB | Mouse IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-451MZ | Human Anti-MSTN Recombinant Antibody (TAB-451MZ) | FuncS, Inhib | Humanized IgG4 |
TAB-458MZ | Anti-Human MSTN Recombinant Antibody (H1L2) | ELISA | Humanized antibody |
TAB-459MZ | Anti-Human MSTN Recombinant Antibody (H2L2) | ELISA, FuncS, Inhib | Humanized antibody |
TAB-451MZ-S(P) | Human Anti-MSTN Recombinant Antibody; scFv Fragment (TAB-451MZ-S(P)) | ELISA | Humanized scFv |
TAB-451MZ-F(E) | Human Anti-MSTN Recombinant Antibody; Fab Fragment (TAB-451MZ-F(E)) | ELISA | Humanized Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-456MZ | Anti-Human MSTN Recombinant Antibody (10B3C) | FuncS, Inhib | Chimeric antibody (mouse/human) |
TAB-456MZ-S(P) | Anti-Human MSTN Recombinant Antibody scFv Fragment (10B3C) | ELISA | Chimeric antibody (mouse/human) |
TAB-456MZ-F(E) | Anti-Human MSTN Recombinant Antibody Fab Fragment (10B3C) | ELISA | Chimeric antibody (mouse/human) |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-452MZ-S(P) | Human Anti-MSTN Recombinant Antibody; scFv Fragment (TAB-452MZ-S(P)) | ELISA | Human scFv |
TAB-460MZ-S(P) | Human Anti-MSTN Recombinant Antibody; scFv Fragment (TAB-460MZ-S(P)) | ELISA | Human scFv |
TAB-461MZ-S(P) | Human Anti-MSTN Recombinant Antibody; scFv Fragment (TAB-461MZ-S(P)) | ELISA | Human scFv |
TAB-460MZ-F(E) | Human Anti-MSTN Recombinant Antibody; Fab Fragment (TAB-460MZ-F(E)) | ELISA | Human Fab |
TAB-461MZ-F(E) | Human Anti-MSTN Recombinant Antibody; Fab Fragment (TAB-461MZ-F(E)) | ELISA | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0013-FY | Mouse Anti-MSTN Recombinant Antibody (clone H8L5) | ELISA | Mouse IgG1 |
VS3-QX791 | Mouse Anti-MSTN Recombinant Antibody (clone 4C9C7) | WB, IHC, ICC, FC, ELISA | Mouse IgG2b |
VS3-QX792 | Mouse Anti-MSTN Recombinant Antibody (clone 8B3A11) | WB, IHC, ICC, FC, ELISA | Mouse IgG2b |
VS3-XY1117 | Mouse Anti-MSTN Recombinant Antibody (clone 6E4B2) | ELISA, WB, IHC, FC | Mouse IgG2b |
VS3-XY1118 | Mouse Anti-MSTN Recombinant Antibody (clone 6E4E6) | ELISA, WB, IHC | Mouse IgG2b |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0013-FY-S(P) | Mouse Anti-MSTN Recombinant Antibody (clone H8L5); scFv Fragment | ELISA | Mouse scFv |
HPAB-0661-WJ-S(P) | Human Anti-MSTN Recombinant Antibody; scFv Fragment (HPAB-0661-WJ-S(P)) | WB | Human scFv |
HPAB-3146LY-S(P) | Human Anti-MSTN Recombinant Antibody; scFv Fragment (HPAB-3146LY-S(P)) | ELISA, FC | Human scFv |
HPAB-0493-FY-S(P) | Mouse Anti-MSTN Recombinant Antibody (clone BP6b- 6); scFv Fragment | Inhib | Mouse scFv |
HPAB-0494-FY-S(P) | Mouse Anti-MSTN Recombinant Antibody (clone BPla-1); scFv Fragment | ELISA | Mouse scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0268CQ-F(E) | Mouse Anti-MSTN Recombinant Antibody; Fab Fragment (HPAB-0268CQ-F(E)) | ELISA, Neut | Mouse Fab |
HPAB-0269CQ-F(E) | Human Anti-MSTN Recombinant Antibody; Fab Fragment (HPAB-0269CQ-F(E)) | ELISA, Neut | Human Fab |
HPAB-0270CQ-F(E) | Mouse Anti-MSTN Recombinant Antibody; Fab Fragment (HPAB-0270CQ-F(E)) | ELISA, FC, DB, Block | Mouse Fab |
HPAB-0271CQ-F(E) | Human Anti-MSTN Recombinant Antibody; Fab Fragment (HPAB-0271CQ-F(E)) | ELISA, FC, DB, Block | Human Fab |
HPAB-0276LY-F(E) | Human Anti-MSTN Recombinant Antibody; Fab Fragment (HPAB-0276LY-F(E)) | ELISA, Neut, in vivo effect | Humanized Fab |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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