Products

Anti-MUC-1 Immunocytokine, scFv-Fc (C595)-IL2 (ACFP-SH017)

This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-MUC-1 scFv-Fc to IL2. It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the MUC-1 as well as the biological activity of IL2. The anti-MUC1-scFv-Fc-IL2 fusion protein that after binding to MUC1-positive tumour cells induces proliferation of peripheral blood T cells and mediates activation of resting NK cells to lysis of MUC1-positive tumour cells. This fusion protein was suitable immunocytokine for the specific immune modulation in the vicinity of MUC1-positive tumours.      

Specifications
Target
MUC-1
Molecule Class
scFv-Fc-IL2
Species Reactivity
Human
Host
Chimeric (Human-Mouse)
Expression Host
CHO
Clone
C595
Related Disease
MUC1-positive tumours
Cytokines 1
IL2
Cytokines 1 Description
Interleukin-2 (IL-2) is an interleukin, a type of cytokine signaling molecule in the immune system. It is a protein that regulates the activities of white blood cells (leukocytes, often lymphocytes) that are responsible for immunity. IL-2 is part of the body's natural response to microbial infection, and in discriminating between foreign ("non-self") and "self". IL-2 mediates its effects by binding to IL-2 receptors, which are expressed by lymphocytes.
Cytokine 1 Species
Human
Applications
This product can be used therapeutically to deliver biologically active ligands to a desired tissue.
Target
Alternative Names
MUC1; mucin 1; cell surface associated; EMA; MCD; PEM; PUM; KL-6
Entrez Gene ID
4582
UniProt ID
P15941

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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