Anti-Mesothelin (MDX-1382)-Duocarmycins ADC (MDX-1204) (CAT#: ADC-L013)
This ADC product is composed of an anti-mesothelin antibody (MDX-1382) conjuagated to Duocarmycins (MDX-1382-Duocarmycins). It has demonstrated a response in ovarian and pancreatic cancers treatment by a MOA (Mechanism of Action) of Bind to DNA minor groove and cause DNA damage.
Specific Inquiry
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line HeLa
(Immunofluorescent staining of human cell line HeLa shows localization to vesicles.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/17172/1276_A4_4_selected.jpg
(Immunofluorescent staining of human cell line HeLa shows localization to vesicles.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/17172/1276_A4_4_selected.jpg
Figure 2 Fallopian tube
(Ciliated cells (cilia axoneme)
Staining:
High
Intensity: Strong
Ciliated cells (tip of cilia)
Staining:
High
Intensity: Strong)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2216/6076_A_7_7.jpg
(Ciliated cells (cilia axoneme)
Staining:
High
Intensity: Strong
Ciliated cells (tip of cilia)
Staining:
High
Intensity: Strong)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2216/6076_A_7_7.jpg
Figure 3 RNA cell line category: Cell line enhanced (CAPAN-2, EFO-21, HeLa, hTCEpi, OE19)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000102854-MSLN
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000102854-MSLN
Figure 3 RNA cell line category: Cell line enhanced (CAPAN-2, EFO-21, HeLa, hTCEpi, OE19)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000102854-MSLN
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000102854-MSLN
Specifications
- Antibody Overview
- Fully human IgG1 monoclonal antibody that binds to mesothelin
- Clone
- MDX-1382
- Antibody Conjugation
- Human
- Linker
- cleavable di-peptide linker
- Linker Class/Description
- Peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood.
- Drug
- Duocarmycins
- Drug Class/Description
- Duocarmycins belong to the minor-groove-binding DNA-alkylating agents (DNA MGBA). The natural duocarmycins are isolated from the culture broth of Streptmyces sp and a series of derivatives has also been synthesized
Target
- Introduction
- This gene encodes a preproprotein that is proteolytically processed to generate two protein products, megakaryocyte potentiating factor and mesothelin. Megakaryocyte potentiating factor functions as a cytokine that can stimulate colony formation of bone marrow megakaryocytes. Mesothelin is a glycosylphosphatidylinositol-anchored cell-surface protein that may function as a cell adhesion protein. This protein is overexpressed in epithelial mesotheliomas, ovarian cancers and in specific squamous cell carcinomas. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.
- Alternative Names
- MPF; SMRP
- Gene ID
- 10232
- UniProt ID
- Q13421
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "MSLN"
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1165z | Mouse Anti-MSLN Recombinant Antibody (clone 44C3) | WB, ELISA, IHC | Mouse IgG2a |
| PABL-658 | Mouse Anti-MSLN Recombinant Antibody (clone MORAb-009) | WB | Mouse IgG |
| MOB-1467MZ | Recombinant Mouse Anti-Human MSLN Antibody (clone L2) | FC, IHC-Fr, WB | Mouse antibody |
| HPAB-0646-CN | Human Anti-MSLN Recombinant Antibody (HPAB-0646-CN) | WB, ELISA, FC | Human IgG1 |
| HPAB-0442LY | Human Anti-MSLN Recombinant Antibody (HPAB-0442LY) | ELISA, FC, IHC, WB | Human IgG1 |
Single-domain Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NABL-009 | Recombinant Anti-human MSLN VHH Single Domain Antibody | WB, IHC, FC, FuncS | Llama VHH |
| HPAB-M0391-YC | Recombinant Llama Anti-MSLN Single Domain Antibody (NbA1/G3A) | ELISA, FC, IF | Llama VHH |
| HPAB-M0392-YC | Recombinant Llama Anti-MSLN Single Domain Antibody (NbC6/F10) | ELISA, FC, IF | Llama VHH |
Chimeric Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-201 | Anti-Human Mesothelin Recombinant Antibody (Amatuximab) | IP, IF, FuncS, FC, Neut, ELISA, IHC | IgG1 - kappa |
Immunotoxin
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AGTO-G052E | Anti-MSLN immunotoxin RG7787 (Fab)-PE | Cytotoxicity assay, Function study | |
| AGTO-G053E | Anti-Msln immunotoxin (IgG)-PE | Cytotoxicity assay, Function study | |
| AGTO-L035E | anti-MSLN immunotoxin K1 (IgG)-PE | Cytotoxicity assay, Functional assay | |
| AGTO-L063E | anti-MSLN immunotoxin 8B35 (scFv)-PE | Cytotoxicity assay, Functional assay |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0833CL | Human Anti-MSLN Recombinant Antibody (TAB-0833CL) | ELISA, FuncS, Activ, FC | Human IgG1 |
| TAB-0833CL-S(P) | Human Anti-MSLN Recombinant Antibody; scFv Fragment (TAB-0833CL-S(P)) | ELISA, FC | Human scFv |
| TAB-0834CL-S(P) | Human Anti-MSLN Recombinant Antibody; scFv Fragment (TAB-0834CL-S(P)) | ELISA, FC | Human scFv |
| TAB-0835CL-S(P) | Human Anti-MSLN Recombinant Antibody; scFv Fragment (TAB-0835CL-S(P)) | ELISA, FC | Human scFv |
| TAB-0833CL-F(E) | Human Anti-MSLN Recombinant Antibody; Fab Fragment (TAB-0833CL-F(E)) | ELISA, FC | Human Fab |
Chicken IgY Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0376MZ | Chicken Anti-MSLN Polyclonal IgY | WB | Chicken antibody |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2302 | Hi-Affi™ Recombinant Rabbit Anti-MSLN Monoclonal Antibody (DS2302AB) | WB | IgG |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0706-CN-S(P) | Mouse Anti-MSLN Recombinant Antibody; scFv Fragment (HPAB-0706-CN-S(P)) | WB, ELISA, FC | Mouse scFv |
| HPAB-0707-CN-S(P) | Mouse Anti-MSLN Recombinant Antibody; scFv Fragment (HPAB-0707-CN-S(P)) | WB, ELISA, FC | Mouse scFv |
| HPAB-0708-CN-S(P) | Mouse Anti-MSLN Recombinant Antibody; scFv Fragment (HPAB-0708-CN-S(P)) | WB, ELISA, FC | Mouse scFv |
| HPAB-S0098-YC-S(P) | Mouse Anti-MSLN Recombinant Antibody (clone SS); scFv Fragment | ELISA | Mouse scFv |
| FAMAB-0257WJ-S(P) | Human Anti-MSLN Recombinant Antibody (clone H1a050); scFv Fragment | ELISA, WB, FC | Human scFv |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0646-CN-F(E) | Human Anti-MSLN Recombinant Antibody; Fab Fragment (HPAB-0646-CN-F(E)) | WB, ELISA, FC | Human Fab |
| HPAB-0442LY-F(E) | Human Anti-MSLN Recombinant Antibody; Fab Fragment (HPAB-0442LY-F(E)) | ELISA, FC, IHC, WB | Human Fab |
| HPAB-0443LY-F(E) | Human Anti-MSLN Recombinant Antibody; Fab Fragment (HPAB-0443LY-F(E)) | ELISA, FC, IHC, WB | Human Fab |
| HPAB-0444LY-F(E) | Human Anti-MSLN Recombinant Antibody; Fab Fragment (HPAB-0444LY-F(E)) | ELISA, FC, IHC, WB | Human Fab |
| HPAB-0884-FY-S(P) | Mouse Anti-MSLN Recombinant Antibody; scFv Fragment (HPAB-0884-FY-S(P)) | FC, IHC, ELISA | Mouse scFv |
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-201 | Afuco™ Anti-MSLN ADCC Recombinant Antibody (Amatuximab), ADCC Enhanced | IP, IF, FuncS, FC, Neut, ELISA | ADCC enhanced antibody |
MHC Tetramer for Cancer
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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