anti-NCAM1 immunotoxin N901 (IgG)-PAP (CAT#: AGTO-L037P)

This immunotoxin was achieved by conjugating/fusing the Anti-NCAM1 monoclonal antibody to Pokeweed antiviral protein. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to small-cell lung cancer (SCLC) cells and the toxin enters cells by receptor-mediated endocytosis. Then PAP is introduced into the cytoplasm where it eventually causes cell death by inactivating ribosomes. It was designed for treatment of small-cell lung cancer (SCLC).


Specific Inquiry
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  • Purity:
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  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location
Normal Tissue
RNA Expression

Specifications

  • Host Species
  • Mouse
  • Species Reactivity
  • Human
  • Clone
  • N901
  • Molecule Class
  • L kappa; IgG1-PAP
  • Toxin Description
  • Pokeweed antiviral protein (PAP) is a type I ribosome inactivating protein isolated from the pokeweed plant, Phytolacca americana. The toxin is introduced into the cytoplasm where it eventually causes cell death by inactivating ribosomes.
  • Applications
  • This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
  • Related Disease
  • Small-cell lung cancer (SCLC)

Target

  • Alternative Names
  • NCAM1; neural cell adhesion molecule 1; CD56; NCAM; MSK39; neural cell adhesion molecule, NCAM; antigen recognized by monoclonal antibody 5.1H11; Small-cell lung cancer; SCLC; Pokeweed Antiviral Protein; Pokeweed; PAP

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

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Humanized Antibody

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TAB-188 Humanized Anti-NCAM1 Recombinant Antibody (clone Lorvotuzumab) ELISA, FC, IP, FuncS, IF, Neut, ICC Humanized (from mouse) IgG1, κ

Immunotoxin

CAT Product Name Application Type
AGTO-L037R anti-NCAM1 immunotoxin N901 (IgG)-RTA Cytotoxicity assay, Functional assay

Blocking Antibody

CAT Product Name Application Type
NEUT-1761CQ Recombinant Mouse Anti-NCAM1 Antibody (MEM188) FC, IHC-Fr, ICC, Separation, BL IgG2a, κ

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-4549 Hi-Affi™ Recombinant Rabbit Anti-NCAM1 Monoclonal Antibody (TH59DS) WB, IF, ICC, FC IgG

Neuroscience Antibody

CAT Product Name Application Type
NS-054CN Mouse Anti-NCAM1 Recombinant Antibody (clone 5A2) ELISA, WB, IP, FC, FuncS Mouse IgG1

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-188 Afuco™ Anti-NCAM1 ADCC Recombinant Antibody (Lorvotuzumab), ADCC Enhanced ELISA, FC, IP, FuncS, IF, Neut ADCC enhanced antibody

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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