Anti-Human NOTCH1 Recombinant Antibody (mAb N248A) (CAT#: TAB-543MZ)

This antibody inhibits Notch-1 signaling, which has a binding affinity KD of less than 0.33 nM to Notch1. It also inhibits both T-cell acute lymphoblastic leukemia (T-ALL) and breast cancer cell growth in cell culture.


Specific Inquiry
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  • Published Data
  • Gene Expression
  • Datasheet
  • MSDS
  • COA

Figure 1 illustrates the Notch-1 dependent luciferase reporter assay results of two monoclonal antibodies: mAb N248A and mAb-C

Figure 1 illustrates the Notch-1 dependent luciferase reporter assay results of two monoclonal antibodies: mAb N248A and mAb-C

Figure 2 illustrates that the luciferase reporter assay indicates that mAb N248A inhibit Jagged-1 induced Notch 1 signaling.

Figure 2 illustrates that the luciferase reporter assay indicates that mAb N248A inhibit Jagged-1 induced Notch 1 signaling.

Hela/Jagged1 cells and N1dP-c16 cells were co-cultured for the luciferase reporter assay. MIgG is a control mouse antibody. The y-axis numbers are luciferase reporter activity readings.


Specifications

  • Immunogen
  • Human Notch1
  • Host Species
  • Mouse
  • Specificity
  • Human
  • Clone
  • mAb N248A
  • Applications
  • ELISA, WB, Inhib, Luciferase reporter assay
  • Related Disease
  • T-cell acute lymphoblastic leukemia (T-ALL), breast cancer

Applications

  • Application Notes
  • The antibody was validated for Inhibition. For details, refer to Published Data.

Target

  • Alternative Names
  • NOTCH1; AOS5; AOVD1; TAN1; hN1

Related Resources

  • Related Diseases

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

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See other products for "Clone mAb N248A"

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Blocking Antibody

CAT Product Name Application Type
NEUT-1786CQ Recombinant Mouse Anti-NOTCH1 Antibody (MHN1-519) FC, BL IgG1, κ

Rabbit Monoclonal Antibody

Neuroscience Antibody

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-H11 Afuco™ Anti-NOTCH1 ADCC Recombinant Antibody (Brontictuzumab), ADCC Enhanced FC, IP, ELISA, Neut, FuncS, IF ADCC enhanced antibody

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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