This antibody shows a neutralization activity and can inhibit Notch ligand-induced signaling with the ability to inhibit growth of HPB-ALL cells.
Figure 1 shows the results of a luciferase reporter assay comparing the antibodies N248A and A12.2.
Figure 2 shows the results of domain swap and an ELISA assay to analyze the binding epitopes of A12.2 as compared to N248A.
Figure 3 shows the analysis of the ability of A12.2 to inhibit growth of HPB-ALL cells.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Download resources about recombinant antibody development and antibody engineering to boost your research.
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-539MZ | Rat Anti-NOTCH1 Recombinant Antibody (TAB-539MZ) | WB, Competition ELISA, Neut | Rat IgG1 |
TAB-540MZ | Rat Anti-NOTCH1 Recombinant Antibody (TAB-540MZ) | WB, Competition ELISA, Neut | Rat IgG1 |
TAB-543MZ | Anti-Human NOTCH1 Recombinant Antibody (mAb N248A) | ELISA, WB, Luciferase reporter assay | |
TAB-539MZ-F(E) | Rat Anti-NOTCH1 Recombinant Antibody; Fab Fragment (TAB-539MZ-F(E)) | WB, Competition ELISA | Rat Fab |
TAB-540MZ-F(E) | Rat Anti-NOTCH1 Recombinant Antibody; Fab Fragment (TAB-540MZ-F(E)) | WB, Competition ELISA | Rat Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-541MZ | Human Anti-NOTCH1 Recombinant Antibody (TAB-541MZ) | Neut, WB | Humanized antibody |
TAB-542MZ | Human Anti-NOTCH1 Recombinant Antibody (TAB-542MZ) | Neut, WB | Humanized antibody |
TAB-541MZ-S(P) | Human Anti-NOTCH1 Recombinant Antibody; scFv Fragment (TAB-541MZ-S(P)) | WB, Competition ELISA | Humanized scFv |
TAB-544MZ-F(E) | Anti-Human NOTCH1 Recombinant Antibody Fab Fragment (A12.2) | ELISA, WB, Luciferase reporter assay | Humanized antibody |
PABX-152-S (P) | Recombinant Human Anti-NRR1 Antibody scFv Fragment | ELISA, Neut, FuncS | scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-545MZ-S(P) | Anti-Human NOTCH1 Recombinant Antibody scFv Fragment (23814) | ELISA | Human antibody |
TAB-546MZ-S(P) | Anti-Human NOTCH1 Recombinant Antibody scFv Fragment (23418.8) | ELISA | Human antibody |
TAB-547MZ-S(P) | Human Anti-NOTCH1 Recombinant Antibody; scFv Fragment (TAB-547MZ-S(P)) | ELISA | Human scFv |
TAB-548MZ-S(P) | Human Anti-NOTCH1 Recombinant Antibody; scFv Fragment (TAB-548MZ-S(P)) | ELISA | Human scFv |
PABX-152-F (E) | Recombinant Human Anti-NRR1 Antibody Fab Fragment | ELISA, Neut, FuncS | Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-1786CQ | Recombinant Mouse Anti-NOTCH1 Antibody (MHN1-519) | FC, BL | IgG1, κ |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-2473 | Hi-Affi™ Recombinant Rabbit Anti-NOTCH1 Monoclonal Antibody (DS2473AB) | WB, IHC | IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0078-YC | Mouse Anti-NOTCH1 Recombinant Antibody (clone OMP-52M51) | IHC | Mouse IgG |
MRO-1102-CN | Recombinant Rabbit Anti-NOTCH1 Monoclonal Antibody (CBACN-405) | WB, IF, IHC, IP, FC | Rabbit IgG |
FN-101CQ | Recombinant Armenian hamster Anti-NOTCH1 Antibody (HMN1-12) | FC, IHC | Armenian Hamster IgG |
HPAB-AP750-YC | Human Anti-NOTCH1 Recombinant Antibody (clone N1wc133) | ELISA, Block | Human IgG1 |
HPAB-AP751-YC | Human Anti-NOTCH1 Recombinant Antibody (clone hN1wc155) | Block | Human IgG1 |
CAT | Product Name | Application | Type |
---|---|---|---|
NS-060CN | Mouse Anti-NOTCH1 Recombinant Antibody (clone 2E6) | FC, IF, ELISA, Inhib, FuncS | Mouse IgG1 |
NS-061CN | Mouse Anti-NOTCH1 Recombinant Antibody (clone 2G10) | FC, IF, ELISA | Mouse IgG1 |
NS-062CN | Mouse Anti-NOTCH1 Recombinant Antibody (clone 2A11) | FC, IF, ELISA, Inhib | Mouse IgG2b |
NS-063CN | Mouse Anti-NOTCH1 Recombinant Antibody (clone 2D11) | FC, IF, ELISA | Mouse IgG1 |
NS-063CN-F(E) | Mouse Anti-NOTCH1 Recombinant Antibody (clone 2D11); Fab Fragment | FC, IF, ELISA | Mouse Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
NS-060CN-F(E) | Mouse Anti-NOTCH1 Recombinant Antibody (clone 2E6); Fab Fragment | FC, IF, ELISA | Mouse Fab |
NS-061CN-F(E) | Mouse Anti-NOTCH1 Recombinant Antibody (clone 2G10); Fab Fragment | FC, IF, ELISA | Mouse Fab |
NS-062CN-F(E) | Mouse Anti-NOTCH1 Recombinant Antibody (clone 2A11); Fab Fragment | FC, IF, ELISA | Mouse Fab |
HPAB-0681-WJ-F(E) | Human Anti-NOTCH1 Recombinant Antibody (clone h52M51); Fab Fragment | ELISA, WB | Humanized Fab |
HPAB-AP750-YC-F(E) | Human Anti-NOTCH1 Recombinant Antibody (clone N1wc133); Fab Fragment | ELISA, FC | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
NS-060CN-S(P) | Mouse Anti-NOTCH1 Recombinant Antibody (clone 2E6); scFv Fragment | FC, IF, ELISA | Mouse scFv |
NS-061CN-S(P) | Mouse Anti-NOTCH1 Recombinant Antibody (clone 2G10); scFv Fragment | FC, IF, ELISA | Mouse scFv |
NS-062CN-S(P) | Mouse Anti-NOTCH1 Recombinant Antibody (clone 2A11); scFv Fragment | FC, IF, ELISA | Mouse scFv |
HPAB-0044LY-S(P) | Mouse Anti-NOTCH1 Recombinant Antibody; scFv Fragment (HPAB-0044LY-S(P)) | WB | Mouse scfv |
HPAB-0681-WJ-S(P) | Human Anti-NOTCH1 Recombinant Antibody (clone h52M51); scFv Fragment | ELISA, WB | Humanized scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
AFC-TAB-H11 | Afuco™ Anti-NOTCH1 ADCC Recombinant Antibody (Brontictuzumab), ADCC Enhanced | FC, IP, ELISA, Neut, FuncS, IF | ADCC enhanced antibody |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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