Anti-Human NOTUM Recombinant Antibody (hSC2.D2.2) (CAT#: TAB-566MZ)
This human Notum neutralizing monoclonal antibody is able to block the Notum activity and impairs Notum mediated proliferation. It does not inhibit the activity of either murine Notum or macaque Notum.
Specific Inquiry
FuncS
Figure 1 are graphical representations of a canonical Wnt3A assay as used to measure the effects of Notum modulators SC2.D2.2 and SC2.A106 (aka 10B3) on soluble Notum constructs Notum-His and Notum-hFc at various concentrations as normalized against uninhibited Wnt-induced luciferase activity.
Inhib
Figure 2 illustrates the ability of the disclosed Notum modulators to inhibit the esterase activity of hNotum in vitro.
Inhib
Figure 3 illustrates the ability of the disclosed Notum modulators to inhibit the lipase activity of hNotum in vitro where the concentration of hNotum is held constant and the concentration of the Notum modulator is varied.
Specifications
- Host Species
- Human
- Type
- Humanized antibody
- Specificity
- Human
- Clone
- hSC2.D2.2
- Applications
- FuncS, Inhib
- Related Disease
- Hyperproliferative disorders
Applications
- Application Notes
- This antibody has been reported for use in Functional Assay, Inhibition.
Target
- Alternative Names
- NOTUM; notum pectinacetylesterase homolog (Drosophila); protein notum homolog
- Gene ID
- 147111
- UniProt ID
- Q6P988
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Mouse Antibody
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-566MZ-S(P) | Anti-Human NOTUM Recombinant Antibody scFv Fragment (hSC2.D2.2) | ELISA | Humanized antibody |
| TAB-569MZ-S(P) | Human Anti-NOTUM Recombinant Antibody; scFv Fragment (TAB-569MZ-S(P)) | ELISA | Humanized scFv |
| TAB-566MZ-F(E) | Anti-Human NOTUM Recombinant Antibody Fab Fragment (hSC2.D2.2) | ELISA | Humanized antibody |
| TAB-569MZ-F(E) | Human Anti-NOTUM Recombinant Antibody; Fab Fragment (TAB-569MZ-F(E)) | ELISA | Humanized Fab |
| TAB-570MZ-F(E) | Human Anti-NOTUM Recombinant Antibody; Fab Fragment (TAB-570MZ-F(E)) | ELISA | Humanized Fab |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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