Anti-NRR1 antibody is a Human antibody of IgG1 class that binds to an NRR1. It developed From human phage antibody libraries with synthetic diversities in the selected complementary determining regions (H1, H2, H3, L3), mimicking the natural diversity of the human IgG repertoire.
Figure 1 Anti-NRR1 is an anti-angiogenic agent that inhibits tumour growth.
a, Mouse neonate retinal assay for endothelial cell sprouting and angiogenesis. Retinal vasculature from mouse neonates treated with the indicated antibodies was visualized following isolectin perfusion. Top panels, scale bar 51mm. Bottom panels, scale bar 50.2mm.
Wu, Y., Cain-Hom, C., Choy, L., Hagenbeek, T. J., de Leon, G. P., Chen, Y., ... & Schahin-Reed, D. (2010). Therapeutic antibody targeting of individual Notch receptors. Nature, 464(7291), 1052.
Figure 2 Selective antibody blocking of Notch1 or Notch2 avoids severe goblet cell metaplasia associated with pan-Notch inhibition.
Immunohistochemical analyses of small intestines, using Alcian blue for mucin to mark secretory goblet cells, anti-Ki-67 staining for proliferation, anti-Hes1 staining for expression of a Notch pathway target, and lysozyme for Paneth cells.
Wu, Y., Cain-Hom, C., Choy, L., Hagenbeek, T. J., de Leon, G. P., Chen, Y., ... & Schahin-Reed, D. (2010). Therapeutic antibody targeting of individual Notch receptors. Nature, 464(7291), 1052.
Figure 3 Anti-NRR1 function as receptor-specific inhibitors in vivo.
Thymus or spleen cells frommice treated with the indicated reagents were harvested for flow cytometry ofCD41/CD81 T cells.
Wu, Y., Cain-Hom, C., Choy, L., Hagenbeek, T. J., de Leon, G. P., Chen, Y., ... & Schahin-Reed, D. (2010). Therapeutic antibody targeting of individual Notch receptors. Nature, 464(7291), 1052.
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• Increased sensitivity
• Confirmed specificity
• High repeatability
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• Sustainable supply
• Animal-free production
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CAT | Product Name | Application | Type |
---|---|---|---|
PSBL-660 | Human Anti-NOTCH1 Recombinant Antibody; scFv Fragment | ELISA | Human scFv |
HPAB-0078-YC-S(P) | Mouse Anti-NOTCH1 Recombinant Antibody (clone OMP-52M51); scFv Fragment | IHC | Mouse scFv |
HPAB-0044LY-S(P) | Mouse Anti-NOTCH1 Recombinant Antibody; scFv Fragment (HPAB-0044LY-S(P)) | WB | Mouse scfv |
HPAB-0681-WJ-S(P) | Human Anti-NOTCH1 Recombinant Antibody (clone h52M51); scFv Fragment | ELISA, WB | Humanized scFv |
HPAB-AP750-YC-S(P) | Human Anti-NOTCH1 Recombinant Antibody (clone N1wc133); scFv Fragment | ELISA, FC | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-539MZ | Rat Anti-NOTCH1 Recombinant Antibody (TAB-539MZ) | WB, Competition ELISA, Neut | Rat IgG1 |
TAB-540MZ | Rat Anti-NOTCH1 Recombinant Antibody (TAB-540MZ) | WB, Competition ELISA, Neut | Rat IgG1 |
TAB-539MZ-S(P) | Rat Anti-NOTCH1 Recombinant Antibody; scFv Fragment (TAB-539MZ-S(P)) | WB, Competition ELISA | Rat scFv |
TAB-540MZ-S(P) | Rat Anti-NOTCH1 Recombinant Antibody; scFv Fragment (TAB-540MZ-S(P)) | WB, Competition ELISA | Rat scFv |
TAB-543MZ-S(P) | Anti-Human NOTCH1 Recombinant Antibody scFv Fragment (mAb N248A) | ELISA, WB, Luciferase reporter assay |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-545MZ | Anti-Human NOTCH1 Recombinant Antibody (23814) | ELISA, FuncS, Inhib, WB, FACS | Human antibody |
TAB-546MZ | Anti-Human NOTCH1 Recombinant Antibody (23418.8) | FuncS, Inhib | Human antibody |
TAB-547MZ | Human Anti-NOTCH1 Recombinant Antibody (TAB-547MZ) | Inhib | Human IgG1 |
TAB-548MZ | Human Anti-NOTCH1 Recombinant Antibody (TAB-548MZ) | FuncS, Inhib | Human IgG1 |
PABX-152-F (E) | Recombinant Human Anti-NRR1 Antibody Fab Fragment | ELISA, Neut, FuncS | Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-541MZ-S(P) | Human Anti-NOTCH1 Recombinant Antibody; scFv Fragment (TAB-541MZ-S(P)) | WB, Competition ELISA | Humanized scFv |
TAB-542MZ-S(P) | Human Anti-NOTCH1 Recombinant Antibody; scFv Fragment (TAB-542MZ-S(P)) | WB, Competition ELISA | Humanized scFv |
TAB-544MZ-S(P) | Anti-Human NOTCH1 Recombinant Antibody scFv Fragment (A12.2) | ELISA, WB, Luciferase reporter assay | Humanized antibody |
TAB-544MZ-F(E) | Anti-Human NOTCH1 Recombinant Antibody Fab Fragment (A12.2) | ELISA, WB, Luciferase reporter assay | Humanized antibody |
PABX-152-S (P) | Recombinant Human Anti-NRR1 Antibody scFv Fragment | ELISA, Neut, FuncS | scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-1786CQ | Recombinant Mouse Anti-NOTCH1 Antibody (MHN1-519) | FC, BL | IgG1, κ |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-2473 | Hi-Affi™ Recombinant Rabbit Anti-NOTCH1 Monoclonal Antibody (DS2473AB) | WB, IHC | IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0078-YC | Mouse Anti-NOTCH1 Recombinant Antibody (clone OMP-52M51) | IHC | Mouse IgG |
HPAB-0681-WJ | Human Anti-NOTCH1 Recombinant Antibody (clone h52M51) | ELISA, WB | Humanized IgG |
HPAB-AP750-YC | Human Anti-NOTCH1 Recombinant Antibody (clone N1wc133) | ELISA, Block | Human IgG1 |
HPAB-AP751-YC | Human Anti-NOTCH1 Recombinant Antibody (clone hN1wc155) | Block | Human IgG1 |
HPAB-AP752-YC | Human Anti-NOTCH1 Recombinant Antibody (clone hN1wc49) | ELISA | Human IgG1 |
CAT | Product Name | Application | Type |
---|---|---|---|
NS-060CN | Mouse Anti-NOTCH1 Recombinant Antibody (clone 2E6) | FC, IF, ELISA, Inhib, FuncS | Mouse IgG1 |
NS-061CN | Mouse Anti-NOTCH1 Recombinant Antibody (clone 2G10) | FC, IF, ELISA | Mouse IgG1 |
NS-062CN | Mouse Anti-NOTCH1 Recombinant Antibody (clone 2A11) | FC, IF, ELISA, Inhib | Mouse IgG2b |
NS-063CN-F(E) | Mouse Anti-NOTCH1 Recombinant Antibody (clone 2D11); Fab Fragment | FC, IF, ELISA | Mouse Fab |
NS-063CN-S(P) | Mouse Anti-NOTCH1 Recombinant Antibody (clone 2D11); scFv Fragment | FC, IF, ELISA | Mouse scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0044LY-F(E) | Mouse Anti-NOTCH1 Recombinant Antibody; Fab Fragment (HPAB-0044LY-F(E)) | WB | Mouse Fab |
HPAB-AP750-YC-F(E) | Human Anti-NOTCH1 Recombinant Antibody (clone N1wc133); Fab Fragment | ELISA, FC | Human Fab |
HPAB-AP751-YC-F(E) | Human Anti-NOTCH1 Recombinant Antibody (clone hN1wc155); Fab Fragment | ELISA, FC | Human Fab |
HPAB-AP752-YC-F(E) | Human Anti-NOTCH1 Recombinant Antibody (clone hN1wc49); Fab Fragment | ELISA, FC | Human Fab |
HPAB-AP753-YC-F(E) | Human Anti-NOTCH1 Recombinant Antibody (clone N1wc104); Fab Fragment | ELISA, FC | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
AFC-TAB-H11 | Afuco™ Anti-NOTCH1 ADCC Recombinant Antibody (Brontictuzumab), ADCC Enhanced | FC, IP, ELISA, Neut, FuncS, IF | ADCC enhanced antibody |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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