Human Anti-Human NTRK1 Recombinant Antibody (CRB0089) (CAT#: TAB-170CQ)
This antibody recognises and binds to an epitope comprised in the TrkA amino acid sequence and inhibits NGF-mediated proliferative response in a dose dependent manner with an IC50 of approximately 43 nM. It is potentially useful in the treatment of diseases, including osteoarthritis pain and chronic pain.
Specific Inquiry
ELISA
Figure 1 Specificity ELISA of anti-TrkA CRB0089 IgG4 mAb versus human TrkA immunoadhesin (hTrkA-Fc) and human TrkB immunoadhesins (hTrkB-Fc), Human antigens were coated at 2 μg/mL.
FC
Figure 2 FACS analysis performed with Bioanalyzer 2100. A cell fluid chip-based fluorescent cytometric assay that runs on Bioanalyzer 2100 (Agilent) for fast characterization of Small population cell phenotypes was assessed.
Specifications
- Host Species
- Human
- Derivation
- Human SPLINT library
- Type
- Human antibody
- Specificity
- Human
- Species Reactivity
- Human, Mouse
- Clone
- CRB0089
- Applications
- ELISA, FC, WB
- Related Disease
- Osteoarthritis pain, chronic pain
Applications
- Application Notes
- This antibody has been tested for use in ELISA, Flow Cytometry, Western Blot. It's recommended that the optimal antibody concentration, dilution, incubition time, etc. be carefully titrated in specific assays.
Target
- Alternative Names
- NTRK1; Neurotrophic receptor tyrosine kinase 1; MTC; TRK; TRK1; TRKA; Trk-A; p140-TrkA; high affinity nerve growth factor receptor; gp140trk; Oncogene TRK; tyrosine kinase receptor A; tropomyosin-related kinase A; TRK1-transforming tyrosine kinase protein
- Gene ID
- 4914
- UniProt ID
- P04629
Related Resources
EGFR Tyrosine Kinase Inhibitor Resistance
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
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Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1229z | Mouse Anti-NTRK1 Recombinant Antibody (clone 18B6) | WB, IP, IF, IHC, ELISA | Mouse IgG2a, κ |
| MRO-2243-CN | Rabbit Anti-NTRK1 Polyclonal Antibody (MRO-2243-CN) | WB, IF, IHC, FC | Rabbit IgG |
| HPAB-0659-YJ | Mouse Anti-NTRK1 Recombinant Antibody (clone 5C3) | Agonist, IHC, IF, Inhib | Mouse IgG2a, κ |
| HPAB-0660-YJ | Human Anti-NTRK1 Recombinant Antibody (clone ch5C3) | Agonist, IHC, IF, Inhib | Chimeric (mouse/human) IgG1, κ |
| VS3-XY1192 | Mouse Anti-NTRK1 Recombinant Antibody (clone 6B2) | ELISA, WB, ICC | Mouse IgG1 |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-170CQ-S(P) | Human Anti-Human NTRK1 Recombinant Antibody scFv Fragment (CRB0089) | ELISA, FC, WB | Human antibody |
| TAB-170CQ-F(E) | Human Anti-Human NTRK1 Recombinant Antibody Fab Fragment (CRB0089) | ELISA, FC, WB | Human antibody |
| TAB-511MZ | Anti-Human NTRK1 Recombinant Antibody (CRB0089) | ELISA, WB, FC | Human antibody |
| TAB-511MZ-S(P) | Anti-Human NTRK1 Recombinant Antibody scFv Fragment (CRB0089) | ELISA, WB, FC | Human antibody |
| TAB-511MZ-F(E) | Anti-Human NTRK1 Recombinant Antibody Fab Fragment (CRB0089) | ELISA, WB, FC | Human antibody |
Chicken IgY Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0759MZ | Chicken Anti-TrkA Polyclonal IgY | ELISA, IHC, IP, WB | Chicken antibody |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABX-182 | Recombinant Mouse Anti-TrkA Antibody (MNAC13) | Neut, FuncS | IgG |
| PABX-182-S (P) | Recombinant Mouse Anti-TrkA Antibody scFv Fragment (MNAC13) | Neut, FuncS | scFv |
| PABX-182-F (E) | Recombinant Mouse Anti-TrkA Antibody Fab Fragment (MNAC13) | Neut, FuncS | Fab |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2508 | Hi-Affi™ Recombinant Rabbit Anti-NTRK1 Monoclonal Antibody (DS2508AB) | WB, IHC | IgG |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0396-CN-F(E) | Human Anti-NTRK1 Recombinant Antibody (clone GBR-VH5(V37A)VL1); Fab Fragment | ELISA, Block | Human Fab |
| HPAB-0728-CN-F(E) | Mouse Anti-NTRK1 Recombinant Antibody (clone CRB0022); Fab Fragment | WB, ELISA, FC | Mouse Fab |
| HPAB-0729-CN-F(E) | Human Anti-NTRK1 Recombinant Antibody (clone CRB0088); Fab Fragment | WB, ELISA, FC | Human Fab |
| HPAB-0730-CN-F(E) | Human Anti-NTRK1 Recombinant Antibody (clone CRB0089_IgG4); Fab Fragment | WB, ELISA, FC | Human Fab |
| HPAB-0660-YJ-F(E) | Human Anti-NTRK1 Recombinant Antibody (clone ch5C3); Fab Fragment | Agonist, IHC, IF, Inhib | Chimeric (mouse/human) Fab |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-AP400-YC-S(P) | Human Anti-NTRK1 Recombinant Antibody (clone CRB0036); scFv Fragment | ELISA, FC, WB, Inhib | Human scFv |
| HPAB-AP401-YC-S(P) | Human Anti-NTRK1 Recombinant Antibody (clone CRB0069); scFv Fragment | ELISA, FC, WB, Inhib | Human scFv |
| HPAB-AP402-YC-S(P) | Human Anti-NTRK1 Recombinant Antibody (clone CRB0072); scFv Fragment | ELISA, FC, WB, Inhib | Human scFv |
| HPAB-AP403-YC-S(P) | Human Anti-NTRK1 Recombinant Antibody (clone CRB0082); scFv Fragment | ELISA, FC, WB, Inhib | Human scFv |
| HPAB-0659-YJ-S(P) | Mouse Anti-NTRK1 Recombinant Antibody (clone 5C3); scFv Fragment | Agonist, IHC, IF, Inhib | Mouse scFv |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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