Anti-Human NTRK2 Recombinant Antibody (C2) (CAT#: TAB-177CQ)

This antibody has a KD for human TrkB of 2.54 nM and blocks BDNF binding to TrkB. It can be potentially used in the treatment of peripheral neuropathies, such as Charcot-Marie-Tooth disease.


Specific Inquiry
  • Size:
  • Conjugation:
  • Endotoxin:
  • Purity:
  • Fc Engineering:
  • Published Data
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Agonist

Figure 1 depicts graphs showing the relative amount of neuron survival in the presence of increasing amounts of several agonist anti-TrkB humanized antibodies using an in vitro assay.

Figure 1 depicts graphs showing the relative amount of neuron survival in the presence of increasing amounts of several agonist anti-TrkB humanized antibodies using an in vitro assay.

Agonist anti-TrkB humanized antibodies C1, C2, 4A6 and 4B12.

FuncS

Figure 2 depicts a graph showing the effect on body weight in high fat diet-induced obesity (DIO) mice after intraperitoneal injections of agonist anti-TrkB agonist antibody.

Figure 2 depicts a graph showing the effect on body weight in high fat diet-induced obesity (DIO) mice after intraperitoneal injections of agonist anti-TrkB agonist antibody.

Antibody or vehicle control was injected on day 0. Body weight was measured on days 1, 2, 3, 6, 7 and 13 after dosing. "***" indicates P<0.001 as compared to vehicle; "**" indicates P<0.01 as compared to vehicle.

FuncS

Figure 3 depicts a graph showing antibody concentrations in serum collected from DIO mice treated with agonist anti-TrkB antibody.

Figure 3 depicts a graph showing antibody concentrations in serum collected from DIO mice treated with agonist anti-TrkB antibody.

DIO mice were bled for serum collection at various time points after intraperitoneal injection of anti-trkB agonist antibody.

FuncS

Figure 4 showing the effect on retinal ganglion cell (RGC) survival after transient glaucomatous injury and intravitreal injection of agonist anti-TrkB antibody.

Figure 4 showing the effect on retinal ganglion cell (RGC) survival after transient glaucomatous injury and intravitreal injection of agonist anti-TrkB antibody.

Average density of RGCs per mm2 in the entire retina.


Specifications

  • Host Species
  • Human
  • Type
  • Humanized antibody
  • Specificity
  • Human
  • Species Reactivity
  • Human, Mouse, Rat
  • Clone
  • C2
  • Applications
  • Agonist, FuncS
  • Related Disease
  • Charcot-Marie-Tooth disease

Applications

  • Application Notes
  • This antibody has been reported for use in Agonist, Functional Assay.

Target

  • Alternative Names
  • NTRK2; Neurotrophic receptor tyrosine kinase 2; TRKB; trk-B; GP145-TrkB; BDNF/NT-3 growth factors receptor; tyrosine kinase receptor B; tropomyosin-related kinase B; BDNF-tropomyosine receptor kinase B

Related Resources

  • Related Diseases

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "Clone C2"

See other products for "NTRK2"

Human Antibody

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-2509 Hi-Affi™ Recombinant Rabbit Anti-NTRK2 Monoclonal Antibody (DS2509AB) WB, IHC, IP IgG

Neuroscience Antibody

CAT Product Name Application Type
NS-095CN Human Anti-NTRK2 Recombinant Antibody (NS-095CN) ELISA Human IgG

Customer Reviews and Q&As

Submit a review or a question
There are currently no Customer reviews or questions for TAB-177CQ. Click the button above to contact us or submit your feedback about this product.
View the frequently asked questions answered by Creative Biolabs Support.

For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Send Inquiry

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

© 2024 Creative Biolabs.
  • 0
  • 0
Cart

    Go to compare