This antibody has a KD for human TrkB of 2.54 nM and blocks BDNF binding to TrkB. It can be potentially used in the treatment of peripheral neuropathies, such as Charcot-Marie-Tooth disease.
Figure 1 depicts graphs showing the relative amount of neuron survival in the presence of increasing amounts of several agonist anti-TrkB humanized antibodies using an in vitro assay.
Agonist anti-TrkB humanized antibodies C1, C2, 4A6 and 4B12.
Figure 2 depicts a graph showing the effect on body weight in high fat diet-induced obesity (DIO) mice after intraperitoneal injections of agonist anti-TrkB agonist antibody.
Antibody or vehicle control was injected on day 0. Body weight was measured on days 1, 2, 3, 6, 7 and 13 after dosing. "***" indicates P<0.001 as compared to vehicle; "**" indicates P<0.01 as compared to vehicle.
Figure 3 depicts a graph showing antibody concentrations in serum collected from DIO mice treated with agonist anti-TrkB antibody.
DIO mice were bled for serum collection at various time points after intraperitoneal injection of anti-trkB agonist antibody.
Figure 4 showing the effect on retinal ganglion cell (RGC) survival after transient glaucomatous injury and intravitreal injection of agonist anti-TrkB antibody.
Average density of RGCs per mm2 in the entire retina.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Download resources about recombinant antibody development and antibody engineering to boost your research.
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-171CQ | Anti-Human NTRK2 Recombinant Antibody (18H6) | ELISA, FC | |
TAB-172CQ | Anti-Human NTRK2 Recombinant Antibody (38B8) | ELISA, FC | |
TAB-173CQ | Anti-Human NTRK2 Recombinant Antibody (6B72C5) | ELISA, WB, IP | |
TAB-174CQ | Anti-Human NTRK2 Recombinant Antibody (5G5D2B5) | FuncS, WB | |
TAB-175CQ | Anti-Human NTRK2 Recombinant Antibody (17D11) | ELISA, FC, WB |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-180CQ | Anti-Human NTRK2 Recombinant Antibody (C20) | FuncS | Human antibody |
TAB-180CQ-S(P) | Anti-Human NTRK2 Recombinant Antibody scFv Fragment (C20) | ELISA, FC, WB | Human antibody |
TAB-180CQ-F(E) | Anti-Human NTRK2 Recombinant Antibody Fab Fragment (C20) | ELISA, FC, WB | Human antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-177CQ-S(P) | Anti-Human NTRK2 Recombinant Antibody scFv Fragment (C2) | ELISA, FC | Humanized antibody |
TAB-178CQ-S(P) | Anti-Human NTRK2 Recombinant Antibody scFv Fragment (A2) | ELISA, FC | Humanized antibody |
TAB-179CQ-S(P) | Anti-Human NTRK2 Recombinant Antibody scFv Fragment (RN1026A) | ELISA, FC | Humanized antibody |
TAB-177CQ-F(E) | Anti-Human NTRK2 Recombinant Antibody Fab Fragment (C2) | ELISA, FC | Humanized antibody |
TAB-178CQ-F(E) | Anti-Human NTRK2 Recombinant Antibody Fab Fragment (A2) | ELISA, FC | Humanized antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-2509 | Hi-Affi™ Recombinant Rabbit Anti-NTRK2 Monoclonal Antibody (DS2509AB) | WB, IHC, IP | IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
NS-095CN | Human Anti-NTRK2 Recombinant Antibody (NS-095CN) | ELISA | Human IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
NS-095CN-S(P) | Human Anti-NTRK2 Recombinant Antibody; scFv Fragment (NS-095CN-S(P)) | ELISA | Human scFv |
PSBC-458 | Mouse Anti-NTRK2 Recombinant Antibody (clone AB20); scFv Fragment | ELISA, FC, IF, Agonist | Mouse scFv |
HPAB-J0197-YC-S(P) | Human Anti-NTRK2 Recombinant Antibody; scFv Fragment (HPAB-J0197-YC-S(P)) | ELISA | Human scFv |
HPAB-J0198-YC-S(P) | Human Anti-NTRK2 Recombinant Antibody; scFv Fragment (HPAB-J0198-YC-S(P)) | ELISA | Human scFv |
HPAB-J0199-YC-S(P) | Human Anti-NTRK2 Recombinant Antibody; scFv Fragment (HPAB-J0199-YC-S(P)) | ELISA | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0662-CN | Human Anti-NTRK2 Recombinant Antibody (HPAB-0662-CN) | ELISA, Neut | Humanized IgG |
HPAB-0663-CN | Human Anti-NTRK2 Recombinant Antibody (HPAB-0663-CN) | ELISA, Neut | Humanized IgG |
HPAB-0664-CN | Human Anti-NTRK2 Recombinant Antibody (HPAB-0664-CN) | ELISA, Neut | Humanized IgG |
HPAB-0665-CN | Human Anti-NTRK2 Recombinant Antibody (HPAB-0665-CN) | ELISA, Neut | Humanized IgG |
HPAB-AP761-YC | Human Anti-NTRK2 Recombinant Antibody (clone 4A6) | FuncS | Humanized IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-N0197-YC-F(E) | Mouse Anti-NTRK2 Recombinant Antibody; Fab Fragment (HPAB-N0197-YC-F(E)) | FuncS, WB | Mouse Fab |
HPAB-N0198-YC-F(E) | Mouse Anti-NTRK2 Recombinant Antibody; Fab Fragment (HPAB-N0198-YC-F(E)) | FuncS | Mouse Fab |
HPAB-N0199-YC-F(E) | Mouse Anti-NTRK2 Recombinant Antibody; Fab Fragment (HPAB-N0199-YC-F(E)) | FuncS | Mouse Fab |
HPAB-N0200-YC-F(E) | Human Anti-NTRK2 Recombinant Antibody; Fab Fragment (HPAB-N0200-YC-F(E)) | FuncS, WB | Humanized Fab |
HPAB-N0201-YC-F(E) | Human Anti-NTRK2 Recombinant Antibody; Fab Fragment (HPAB-N0201-YC-F(E)) | FuncS | Humanized Fab |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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