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Anti-NTRK3 Therapeutic Antibody (2B7) (TAB-181CQ)

The antibody binds to the juxtamembrane domain of TrkC receptors and causes activation of some but not all of the TrkC signaling pathways that NT-3 can activate. It can treat some diseases which require activation of TrkC, such as amyotrophic lateral sclerosis and other neurodegenerative conditions and motor neuron diseases.      

Specifications
Immunogen
A peptide (ESTDNFILFDEVSPTPPI) near the D5 domain of human TrkC
Host
Mouse
Specificity
Human
Species Reactivity
Human, Rat, Mouse
Clone
2B7
Applications
Used for immunoassay techniques such as: Enzyme-linked Immunosorbent Assay; Flow Cytometry; Immunofluorescence; Western Blot
Related Disease
Amyotrophic lateral sclerosis (ALS)
Target
Alternative Names
NTRK3; Neurotrophic receptor tyrosine kinase 3; TRKC; gp145(trkC); NT-3 growth factor receptor; GP145-TrkC; ETV6-NTRK3 fusion; tyrosine kinase receptor C
Entrez Gene ID
4916
UniProt ID
Q96CY4

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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