Products

Anti-NUP88 Intrabody [(D-Arg)9] (IAB-B063(A))

Recombinant anti-NUP88 intrabody linked to (D-Arg)9 works within cells to bind the nuclear pore protein NUP88, expressed in E. coli cells. Anti-Nup88 intrabody, an anti-sense oligonucleotide or nucleic acid which is complementary to at least a functional part of a Nup88 RNA or wherein the compound is a peptide, peptide-like or non-peptide Nup88 inhibitor which can be identified by contacting the compound or libraries of peptido- mimetics, peptides, DNA or cDNA expression, combinatorial chemistry or phage display with substantially purified Nup88, fragments thereof or structural analogues thereof.      

Specifications
Immunogen
human nucleoporin 88kDa
Host
rabbit
Type
scFv-(D-Arg)9
Cell Penetrating Peptide
(D-Arg)9
It has been proven that polyarginine peptides composed of nine arginine amino acids (Arg-9) are able to translocate across cells very efficiently. This raises the question if molecular dynamics simulations would show a similar pathway for this highly hydrophilic and charged peptide as predicted for the Tat peptide. The simplicity of Arg-9 over other CPPs also helps isolate the role of the Arg sidechain on the translocation without the effect of other sidechains. Therefore, in this work we study computationally the translocation of Arg-9 through a lipid bilayer and show that the translocation mechanism is the same as for the Tat peptide.
Species Reactivity
human
Applications
Can be useful in applications such as: Enzyme-linked Immunosorbent Assay; Neutralization; Functional studies
Target
Alternative Names
NUP88; nucleoporin 88kDa; nuclear pore complex protein Nup88; karyoporin; nucleoporin 88kD; nucleoporin Nup88; 88 kDa nucleoporin; nuclear pore complex protein 88
Entrez Gene ID
4927
UniProt ID
Q99567

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

Our customer service representatives are available 24 hours a day, from Monday to Sunday. Contact Us
Send Inquiry Now!
Name:
* Phone:
* E-mail Address:
* Service & Products Interested:
Project Description:
* Verification Code:
Please input "biolabs"(case insensitive) as verification code.
Contact Us to Order
Tel: 1-631-871-5806
Fax: 1-631-207-8356
Email:

45-1 Ramsey Road, Shirley, NY 11967, USA     Tel: 1-631-871-5806    Fax: 1-631-207-8356    Email:
Terms of Service-Privacy Policy     © 2007 - 2017 Creative-Biolabs All Rights Reserved