anti-Ngfr immunotoxin MC-192 (IgG)-Sap (CAT#: AGTO-L038S)

This immunotoxin was achieved by conjugating/fusing the Anti-Ngfr monoclonal antibody to saporin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to neurons and enters cells by receptor-mediated endocytosis. Upon release of the conjugate from endosomes, the saporin toxin catalytically renders the large subunit ribosomes unable to bind the elongation factors and inhibits protein synthesis. It was designed for treatment of Alzheimer's disease.


Specific Inquiry
  • Size:
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  • Endotoxin:
  • Purity:
  • Fc Engineering:
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location
Normal Tissue
RNA Expression

Specifications

  • Host Species
  • Mouse
  • Species Reactivity
  • Rat
  • Clone
  • MC-192
  • Molecule Class
  • L kappa; IgG1-Sap
  • Toxin Description
  • Saporin is a so-called ribosome inactivating protein (RIP), due to its N-glycosidase activity, from the seeds of Saponaria officinalis (common name: soapwort).Saporin depurinate the ribosomal RNA in a specific position; rendering the large subunit of ribosomes unable to bind the elongation factors. The consequent arrest of protein synthesis is responsible for the cytotoxicity.
  • Applications
  • This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
  • Related Disease
  • Alzheimer's disease

Target

  • Alternative Names
  • NGFR; nerve growth factor receptor (TNFR superfamily, member 16); p75; LNGFR; p75NTR; p75NGFR; Tnfrsf16; tumor necrosis factor receptor superfamily member 16; NGF receptor; p75 neurotrophin receptor; low affinity neurotrophin receptor p75NTR; low-affinity nerve growth factor receptor; Alzheimer's disease; saporin; saporin-6; saporin-S6; SAP

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

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Blocking Antibody

CAT Product Name Application Type
NEUT-1778CQ Recombinant Mouse Anti-NGFR Antibody (ME20.4) EM, ELISA, FC, ICC/IF, IHC-P, Inhib, IP, RIA, WB IgG1

Neutralizing Antibody

CAT Product Name Application Type
NEUT-1779CQ Recombinant Mouse Anti-NGFR Antibody (5H1) IHC, IP, Neut, WB IgG1

Rabbit Monoclonal Antibody

Recombinant Antibody

Fab Fragment Antibody

CAT Product Name Application Type
HPAB-0276CQ-F(E) Mouse Anti-NGFR Recombinant Antibody (clone MC192); Fab Fragment ELISA, IHC, IP, WB Mouse Fab

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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