This monoclonal antibody against Propionibacterium acnes can be potentially used for preventing and treating P. acnes infections.
Figure 1 Antigen-specificity of phage antibodies.
Sixty randomly selected phage antibodies were tested for antigen specificity (black bar, P. acnes; white bar, fish geratin (FG)) using solid-phase enzyme-linked immunosorbent assay (ELISA).
Generation of human monoclonal antibodies against Propionibacterium acnes by applying the phage display method to human peripheral blood mononuclear cells immunized in vitro
Figure 2 Antigen-specific binding of recombinant human IgG.
Antigen-specific binding of human IgG monoclonal antibodies was evaluated by direct enzyme-linked immunosorbent assay (ELISA). The heavy chain and light chain variable region (VH and VL, respectively) genes of the phage antibodies (a, D9; b, F6; and c, F10) were amplified and inserted into their respective human IgG expression vectors. Chinese hamster ovary cells (CHO) cells were transfected with these expression vectors and cultured for several weeks. ELISA was used to evaluate the antigen specificity of these antibodies in the culture supernatants.
Generation of human monoclonal antibodies against Propionibacterium acnes by applying the phage display method to human peripheral blood mononuclear cells immunized in vitro
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Download resources about recombinant antibody development and antibody engineering to boost your research.
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-168MZ | Anti-P. acnes Recombinant Antibody (D9) (MRO-168MZ) | ELISA | Human antibody |
MRO-170MZ | Anti-P. acnes Recombinant Antibody (F10) (MRO-170MZ) | ELISA | Human antibody |
MRO-168MZ-F(E) | Anti-P. acnes Recombinant Antibody Fab Fragment (D9) (MRO-168MZ-F(E)) | ELISA | Human antibody |
MRO-169MZ-F(E) | Anti-P. acnes Recombinant Antibody Fab Fragment (F6) (MRO-169MZ-F(E)) | ELISA | Human antibody |
MRO-170MZ-F(E) | Anti-P. acnes Recombinant Antibody Fab Fragment (F10) (MRO-170MZ-F(E)) | ELISA | Human antibody |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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