Products

Anti-PD-L1 Immunocytokine, IgG (atezolizumab)-IL-15Rα sushi domain/IL-15 (ACFP-SH146)

This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-PD-L1 IgG to IL-15Rα sushi domain/IL-15. It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the PD-L1 as well as the biological activity of IL-15Rα sushi domain/IL-15. This antibody-cytokine fusion protein fusion protein has higher affinity to PD-L1, silenced binding activity to Fc receptors and better ability to increase the secretion of Th1 cytokine, i.e. gamma IFN and the cytotoxicity of CD8 T-cells and NK cells to tumor cells as assessed in immunological assays. This immunocytokine was designed for treating cancer.      

Specifications
Target
PD-L1
Molecule Class
L Kappa; IgG1-IL-15Rα sushi domain/IL-15
Species Reactivity
Human
Host
Human
Expression Host
CHO
Clone
atezolizumab
Related Disease
Cancer
Cytokines 1
IL-15Rα sushi domain/IL-15
Cytokines 1 Description
This recombinant protein is the heterocomplex of the mouse IL-15 linked to soluble IL-15 receptor alpha chain (sushi domain) via a GS linker.
Interleukin 15 (IL-15) is a cytokine that stimulates T and NK cell proliferation and differentiation. IL-15 regulates macrophage proinflammatory and chemotactic protein production. In addition, it induces differentiation of monocytes towards dendritic cells. The receptor for IL-15 is a high affinity heterotrimeric receptor composed of IL-15Rα and 2 additional subunits of the IL-2 receptor (beta and gamma). Upon activation, the receptor complex signals via the Stat and JAK pathways.
Cytokine 1 Species
Human
Applications
This product can be used therapeutically to deliver biologically active ligands to a desired tissue.
Target
Alternative Names
CD274; PD-L1; PDCD1L1; B7-H; Programmed Death Ligand 1; Programmed Cell Death 1 Ligand 1; PDCD1LG1; B7H1
Entrez Gene ID
29126
UniProt ID
Q9NZQ7

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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